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TLR6 (toll like receptor 6)

Identity

Alias_namestoll-like receptor 6
Alias_symbol (synonym)CD286
Other alias
HGNC (Hugo) TLR6
LocusID (NCBI) 10333
Atlas_Id 43954
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 38825329 and ends at 38858438 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TLR6 (4p14) / PPP4R1 (18p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR6   16711
Cards
Entrez_Gene (NCBI)TLR6  10333  toll like receptor 6
AliasesCD286
GeneCards (Weizmann)TLR6
Ensembl hg19 (Hinxton)ENSG00000174130 [Gene_View]  chr4:38825329-38858438 [Contig_View]  TLR6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174130 [Gene_View]  chr4:38825329-38858438 [Contig_View]  TLR6 [Vega]
ICGC DataPortalENSG00000174130
TCGA cBioPortalTLR6
AceView (NCBI)TLR6
Genatlas (Paris)TLR6
WikiGenes10333
SOURCE (Princeton)TLR6
Genetics Home Reference (NIH)TLR6
Genomic and cartography
GoldenPath hg19 (UCSC)TLR6  -     chr4:38825329-38858438 -  4p14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TLR6  -     4p14   [Description]    (hg38-Dec_2013)
EnsemblTLR6 - 4p14 [CytoView hg19]  TLR6 - 4p14 [CytoView hg38]
Mapping of homologs : NCBITLR6 [Mapview hg19]  TLR6 [Mapview hg38]
OMIM605403   
Gene and transcription
Genbank (Entrez)AB020807 AB445652 AK313618 BC111755 BF512068
RefSeq transcript (Entrez)NM_006068
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_028087 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)TLR6
Cluster EST : UnigeneHs.743572 [ NCBI ]
CGAP (NCI)Hs.743572
Alternative Splicing GalleryENSG00000174130
Gene ExpressionTLR6 [ NCBI-GEO ]   TLR6 [ EBI - ARRAY_EXPRESS ]   TLR6 [ SEEK ]   TLR6 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10333
GTEX Portal (Tissue expression)TLR6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2C9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2C9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2C9
Splice isoforms : SwissVarQ9Y2C9
PhosPhoSitePlusQ9Y2C9
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    TIR_dom    TLR6    Toll-like_receptor   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRCT (PF01463)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01463    pfam01582   
Domain families : Smart (EMBL)LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR6
DMDM Disease mutations10333
Blocks (Seattle)TLR6
PDB (SRS)4OM7   
PDB (PDBSum)4OM7   
PDB (IMB)4OM7   
PDB (RSDB)4OM7   
Structural Biology KnowledgeBase4OM7   
SCOP (Structural Classification of Proteins)4OM7   
CATH (Classification of proteins structures)4OM7   
SuperfamilyQ9Y2C9
Human Protein AtlasENSG00000174130
Peptide AtlasQ9Y2C9
HPRD05656
IPIIPI00294125   IPI00718965   IPI00966841   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2C9
IntAct (EBI)Q9Y2C9
FunCoupENSG00000174130
BioGRIDTLR6
STRING (EMBL)TLR6
ZODIACTLR6
Ontologies - Pathways
QuickGOQ9Y2C9
Ontology : AmiGOtoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  activation of NF-kappaB-inducing kinase activity  phagocytic vesicle membrane  toll-like receptor 6 signaling pathway  Toll-like receptor 2-Toll-like receptor 6 protein complex  Toll-like receptor 2 binding  toll-like receptor TLR6:TLR2 signaling pathway  T-helper 1 type immune response  detection of diacyl bacterial lipopeptide  defense response to bacterium  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  innate immune response  membrane raft  positive regulation of interleukin-6 biosynthetic process  interleukin-1 beta secretion  regulation of cytokine secretion  lipopeptide binding  lipopeptide binding  cellular response to diacyl bacterial lipopeptide  positive regulation of NLRP3 inflammasome complex assembly  
Ontology : EGO-EBItoll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  activation of NF-kappaB-inducing kinase activity  phagocytic vesicle membrane  toll-like receptor 6 signaling pathway  Toll-like receptor 2-Toll-like receptor 6 protein complex  Toll-like receptor 2 binding  toll-like receptor TLR6:TLR2 signaling pathway  T-helper 1 type immune response  detection of diacyl bacterial lipopeptide  defense response to bacterium  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  innate immune response  membrane raft  positive regulation of interleukin-6 biosynthetic process  interleukin-1 beta secretion  regulation of cytokine secretion  lipopeptide binding  lipopeptide binding  cellular response to diacyl bacterial lipopeptide  positive regulation of NLRP3 inflammasome complex assembly  
Pathways : KEGGPhagosome    Toll-like receptor signaling pathway    Chagas disease (American trypanosomiasis)    Tuberculosis   
NDEx NetworkTLR6
Atlas of Cancer Signalling NetworkTLR6
Wikipedia pathwaysTLR6
Orthology - Evolution
OrthoDB10333
GeneTree (enSembl)ENSG00000174130
Phylogenetic Trees/Animal Genes : TreeFamTLR6
HOVERGENQ9Y2C9
HOGENOMQ9Y2C9
Homologs : HomoloGeneTLR6
Homology/Alignments : Family Browser (UCSC)TLR6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR6
dbVarTLR6
ClinVarTLR6
1000_GenomesTLR6 
Exome Variant ServerTLR6
ExAC (Exome Aggregation Consortium)TLR6 (select the gene name)
Genetic variants : HAPMAP10333
Genomic Variants (DGV)TLR6 [DGVbeta]
DECIPHER (Syndromes)4:38825329-38858438  ENSG00000174130
CONAN: Copy Number AnalysisTLR6 
Mutations
ICGC Data PortalTLR6 
TCGA Data PortalTLR6 
Broad Tumor PortalTLR6
OASIS PortalTLR6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch TLR6
DgiDB (Drug Gene Interaction Database)TLR6
DoCM (Curated mutations)TLR6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR6 (select a term)
intoGenTLR6
Cancer3DTLR6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605403   
Orphanet
MedgenTLR6
Genetic Testing Registry TLR6
NextProtQ9Y2C9 [Medical]
TSGene10333
GENETestsTLR6
Huge Navigator TLR6 [HugePedia]
snp3D : Map Gene to Disease10333
BioCentury BCIQTLR6
ClinGenTLR6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10333
Chemical/Pharm GKB GenePA38183
Clinical trialTLR6
Miscellaneous
canSAR (ICR)TLR6 (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR6
EVEXTLR6
GoPubMedTLR6
iHOPTLR6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:15 CET 2017

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