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TLR7 (toll like receptor 7)

Identity

Alias_namestoll-like receptor 7
Other aliasTLR7-like
HGNC (Hugo) TLR7
LocusID (NCBI) 51284
Atlas_Id 43892
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 12867083 and ends at 12890361 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLSTN1 (1p36.22) / TLR7 (Xp22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TLR7   15631
Cards
Entrez_Gene (NCBI)TLR7  51284  toll like receptor 7
AliasesTLR7-like
GeneCards (Weizmann)TLR7
Ensembl hg19 (Hinxton)ENSG00000196664 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196664 [Gene_View]  chrX:12867083-12890361 [Contig_View]  TLR7 [Vega]
ICGC DataPortalENSG00000196664
TCGA cBioPortalTLR7
AceView (NCBI)TLR7
Genatlas (Paris)TLR7
WikiGenes51284
SOURCE (Princeton)TLR7
Genetics Home Reference (NIH)TLR7
Genomic and cartography
GoldenPath hg38 (UCSC)TLR7  -     chrX:12867083-12890361 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR7  -     Xp22.2   [Description]    (hg19-Feb_2009)
EnsemblTLR7 - Xp22.2 [CytoView hg19]  TLR7 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBITLR7 [Mapview hg19]  TLR7 [Mapview hg38]
OMIM300365   
Gene and transcription
Genbank (Entrez)AB445659 AF240467 AF245702 AK313858 AY358292
RefSeq transcript (Entrez)NM_016562
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR7
Cluster EST : UnigeneHs.659215 [ NCBI ]
CGAP (NCI)Hs.659215
Alternative Splicing GalleryENSG00000196664
Gene ExpressionTLR7 [ NCBI-GEO ]   TLR7 [ EBI - ARRAY_EXPRESS ]   TLR7 [ SEEK ]   TLR7 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51284
GTEX Portal (Tissue expression)TLR7
Human Protein AtlasENSG00000196664-TLR7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYK1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYK1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYK1
Splice isoforms : SwissVarQ9NYK1
PhosPhoSitePlusQ9NYK1
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_5    TIR_dom    TLR7   
Domain families : Pfam (Sanger)LRR_5 (PF13306)    LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13306    pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR7
DMDM Disease mutations51284
Blocks (Seattle)TLR7
SuperfamilyQ9NYK1
Human Protein Atlas [tissue]ENSG00000196664-TLR7 [tissue]
Peptide AtlasQ9NYK1
HPRD02295
IPIIPI00009812   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYK1
IntAct (EBI)Q9NYK1
FunCoupENSG00000196664
BioGRIDTLR7
STRING (EMBL)TLR7
ZODIACTLR7
Ontologies - Pathways
QuickGOQ9NYK1
Ontology : AmiGOGolgi membrane  microglial cell activation  regulation of protein phosphorylation  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  double-stranded RNA binding  single-stranded RNA binding  single-stranded RNA binding  transmembrane signaling receptor activity  cytoplasm  lysosome  endosome  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  inflammatory response  I-kappaB phosphorylation  drug binding  endosome membrane  integral component of membrane  early phagosome  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  toll-like receptor 7 signaling pathway  toll-like receptor 9 signaling pathway  siRNA binding  endolysosome membrane  positive regulation of NF-kappaB import into nucleus  receptor complex  positive regulation of interferon-gamma biosynthetic process  innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of inflammatory response  defense response to virus  cellular response to mechanical stimulus  
Ontology : EGO-EBIGolgi membrane  microglial cell activation  regulation of protein phosphorylation  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  double-stranded RNA binding  single-stranded RNA binding  single-stranded RNA binding  transmembrane signaling receptor activity  cytoplasm  lysosome  endosome  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  inflammatory response  I-kappaB phosphorylation  drug binding  endosome membrane  integral component of membrane  early phagosome  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  toll-like receptor 7 signaling pathway  toll-like receptor 9 signaling pathway  siRNA binding  endolysosome membrane  positive regulation of NF-kappaB import into nucleus  receptor complex  positive regulation of interferon-gamma biosynthetic process  innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of inflammatory response  defense response to virus  cellular response to mechanical stimulus  
Pathways : BIOCARTAToll-Like Receptor Pathway [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTLR7
Atlas of Cancer Signalling NetworkTLR7
Wikipedia pathwaysTLR7
Orthology - Evolution
OrthoDB51284
GeneTree (enSembl)ENSG00000196664
Phylogenetic Trees/Animal Genes : TreeFamTLR7
HOVERGENQ9NYK1
HOGENOMQ9NYK1
Homologs : HomoloGeneTLR7
Homology/Alignments : Family Browser (UCSC)TLR7
Gene fusions - Rearrangements
Fusion : QuiverTLR7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR7
dbVarTLR7
ClinVarTLR7
1000_GenomesTLR7 
Exome Variant ServerTLR7
ExAC (Exome Aggregation Consortium)ENSG00000196664
GNOMAD BrowserENSG00000196664
Genetic variants : HAPMAP51284
Genomic Variants (DGV)TLR7 [DGVbeta]
DECIPHERTLR7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR7 
Mutations
ICGC Data PortalTLR7 
TCGA Data PortalTLR7 
Broad Tumor PortalTLR7
OASIS PortalTLR7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch TLR7
DgiDB (Drug Gene Interaction Database)TLR7
DoCM (Curated mutations)TLR7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR7 (select a term)
intoGenTLR7
Cancer3DTLR7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300365   
Orphanet
DisGeNETTLR7
MedgenTLR7
Genetic Testing Registry TLR7
NextProtQ9NYK1 [Medical]
TSGene51284
GENETestsTLR7
Target ValidationTLR7
Huge Navigator TLR7 [HugePedia]
snp3D : Map Gene to Disease51284
BioCentury BCIQTLR7
ClinGenTLR7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51284
Chemical/Pharm GKB GenePA38008
Clinical trialTLR7
Miscellaneous
canSAR (ICR)TLR7 (select the gene name)
Probes
Litterature
PubMed287 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR7
EVEXTLR7
GoPubMedTLR7
iHOPTLR7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:41:51 CET 2018
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