Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TLR8 (toll like receptor 8)

Identity

Alias_namestoll-like receptor 8
Alias_symbol (synonym)CD288
Other alias
HGNC (Hugo) TLR8
LocusID (NCBI) 51311
Atlas_Id 45973
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 12906620 and ends at 12923169 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR8   15632
Cards
Entrez_Gene (NCBI)TLR8  51311  toll like receptor 8
AliasesCD288
GeneCards (Weizmann)TLR8
Ensembl hg19 (Hinxton)ENSG00000101916 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101916 [Gene_View]  chrX:12906620-12923169 [Contig_View]  TLR8 [Vega]
ICGC DataPortalENSG00000101916
TCGA cBioPortalTLR8
AceView (NCBI)TLR8
Genatlas (Paris)TLR8
WikiGenes51311
SOURCE (Princeton)TLR8
Genetics Home Reference (NIH)TLR8
Genomic and cartography
GoldenPath hg38 (UCSC)TLR8  -     chrX:12906620-12923169 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR8  -     Xp22.2   [Description]    (hg19-Feb_2009)
EnsemblTLR8 - Xp22.2 [CytoView hg19]  TLR8 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBITLR8 [Mapview hg19]  TLR8 [Mapview hg38]
OMIM300366   
Gene and transcription
Genbank (Entrez)AB445666 AF245703 AF246971 AK075117 AK297024
RefSeq transcript (Entrez)NM_016610 NM_138636
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR8
Cluster EST : UnigeneHs.660543 [ NCBI ]
CGAP (NCI)Hs.660543
Alternative Splicing GalleryENSG00000101916
Gene ExpressionTLR8 [ NCBI-GEO ]   TLR8 [ EBI - ARRAY_EXPRESS ]   TLR8 [ SEEK ]   TLR8 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51311
GTEX Portal (Tissue expression)TLR8
Human Protein AtlasENSG00000101916-TLR8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR97   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR97  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR97
Splice isoforms : SwissVarQ9NR97
PhosPhoSitePlusQ9NR97
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR8   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR8
DMDM Disease mutations51311
Blocks (Seattle)TLR8
PDB (SRS)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
PDB (PDBSum)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
PDB (IMB)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
PDB (RSDB)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
Structural Biology KnowledgeBase3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
SCOP (Structural Classification of Proteins)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
CATH (Classification of proteins structures)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH   
SuperfamilyQ9NR97
Human Protein Atlas [tissue]ENSG00000101916-TLR8 [tissue]
Peptide AtlasQ9NR97
HPRD02296
IPIIPI00009910   IPI00985135   IPI00335051   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR97
IntAct (EBI)Q9NR97
FunCoupENSG00000101916
BioGRIDTLR8
STRING (EMBL)TLR8
ZODIACTLR8
Ontologies - Pathways
QuickGOQ9NR97
Ontology : AmiGOGolgi membrane  microglial cell activation  regulation of protein phosphorylation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  receptor activity  receptor activity  endoplasmic reticulum membrane  integral component of plasma membrane  inflammatory response  I-kappaB kinase/NF-kappaB signaling  drug binding  response to virus  external side of plasma membrane  endosome membrane  integral component of membrane  immunoglobulin mediated immune response  toll-like receptor 8 signaling pathway  toll-like receptor 9 signaling pathway  endolysosome membrane  positive regulation of interferon-gamma biosynthetic process  innate immune response  positive regulation of innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of interleukin-1 beta secretion  defense response to virus  cellular response to mechanical stimulus  positive regulation of interleukin-6 secretion  negative regulation of interleukin-12 secretion  
Ontology : EGO-EBIGolgi membrane  microglial cell activation  regulation of protein phosphorylation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  receptor activity  receptor activity  endoplasmic reticulum membrane  integral component of plasma membrane  inflammatory response  I-kappaB kinase/NF-kappaB signaling  drug binding  response to virus  external side of plasma membrane  endosome membrane  integral component of membrane  immunoglobulin mediated immune response  toll-like receptor 8 signaling pathway  toll-like receptor 9 signaling pathway  endolysosome membrane  positive regulation of interferon-gamma biosynthetic process  innate immune response  positive regulation of innate immune response  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of interleukin-1 beta secretion  defense response to virus  cellular response to mechanical stimulus  positive regulation of interleukin-6 secretion  negative regulation of interleukin-12 secretion  
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTLR8
Atlas of Cancer Signalling NetworkTLR8
Wikipedia pathwaysTLR8
Orthology - Evolution
OrthoDB51311
GeneTree (enSembl)ENSG00000101916
Phylogenetic Trees/Animal Genes : TreeFamTLR8
HOVERGENQ9NR97
HOGENOMQ9NR97
Homologs : HomoloGeneTLR8
Homology/Alignments : Family Browser (UCSC)TLR8
Gene fusions - Rearrangements
Tumor Fusion PortalTLR8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR8
dbVarTLR8
ClinVarTLR8
1000_GenomesTLR8 
Exome Variant ServerTLR8
ExAC (Exome Aggregation Consortium)ENSG00000101916
GNOMAD BrowserENSG00000101916
Genetic variants : HAPMAP51311
Genomic Variants (DGV)TLR8 [DGVbeta]
DECIPHERTLR8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR8 
Mutations
ICGC Data PortalTLR8 
TCGA Data PortalTLR8 
Broad Tumor PortalTLR8
OASIS PortalTLR8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TLR8
DgiDB (Drug Gene Interaction Database)TLR8
DoCM (Curated mutations)TLR8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR8 (select a term)
intoGenTLR8
Cancer3DTLR8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300366   
Orphanet
DisGeNETTLR8
MedgenTLR8
Genetic Testing Registry TLR8
NextProtQ9NR97 [Medical]
TSGene51311
GENETestsTLR8
Target ValidationTLR8
Huge Navigator TLR8 [HugePedia]
snp3D : Map Gene to Disease51311
BioCentury BCIQTLR8
ClinGenTLR8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51311
Chemical/Pharm GKB GenePA38009
Clinical trialTLR8
Miscellaneous
canSAR (ICR)TLR8 (select the gene name)
Probes
Litterature
PubMed173 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR8
EVEXTLR8
GoPubMedTLR8
iHOPTLR8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:38:36 CET 2017

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