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TLR8 (toll like receptor 8)

Identity

Alias (NCBI)CD288
HGNC (Hugo) TLR8
HGNC Alias symbCD288
HGNC Previous nametoll-like receptor 8
LocusID (NCBI) 51311
Atlas_Id 45973
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 12906620 and ends at 12923169 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TLR8   15632
Cards
Entrez_Gene (NCBI)TLR8    toll like receptor 8
AliasesCD288
GeneCards (Weizmann)TLR8
Ensembl hg19 (Hinxton)ENSG00000101916 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101916 [Gene_View]  ENSG00000101916 [Sequence]  chrX:12906620-12923169 [Contig_View]  TLR8 [Vega]
ICGC DataPortalENSG00000101916
TCGA cBioPortalTLR8
AceView (NCBI)TLR8
Genatlas (Paris)TLR8
SOURCE (Princeton)TLR8
Genetics Home Reference (NIH)TLR8
Genomic and cartography
GoldenPath hg38 (UCSC)TLR8  -     chrX:12906620-12923169 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR8  -     Xp22.2   [Description]    (hg19-Feb_2009)
GoldenPathTLR8 - Xp22.2 [CytoView hg19]  TLR8 - Xp22.2 [CytoView hg38]
ImmunoBaseENSG00000101916
Genome Data Viewer NCBITLR8 [Mapview hg19]  
OMIM300366   
Gene and transcription
Genbank (Entrez)AB445666 AF245703 AF246971 AK075117 AK297024
RefSeq transcript (Entrez)NM_016610 NM_138636
Consensus coding sequences : CCDS (NCBI)TLR8
Gene ExpressionTLR8 [ NCBI-GEO ]   TLR8 [ EBI - ARRAY_EXPRESS ]   TLR8 [ SEEK ]   TLR8 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR8 [ Firebrowse - Broad ]
GenevisibleExpression of TLR8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51311
GTEX Portal (Tissue expression)TLR8
Human Protein AtlasENSG00000101916-TLR8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR97   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR97  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR97
PhosPhoSitePlusQ9NR97
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    TIR_dom    TLR8    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR8
PDB (RSDB)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
PDB Europe3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
PDB (PDBSum)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
PDB (IMB)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
Structural Biology KnowledgeBase3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
SCOP (Structural Classification of Proteins)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
CATH (Classification of proteins structures)3W3G    3W3J    3W3K    3W3L    3W3M    3W3N    3WN4    4QBZ    4QC0    4R07    4R08    4R09    4R0A    4R6A    5AWA    5AWB    5AWC    5AWD    5AZ5    5HDH    5WYX    5WYZ    5Z14    5Z15    6KYA    6TY5    6V9U   
SuperfamilyQ9NR97
AlphaFold pdb e-kbQ9NR97   
Human Protein Atlas [tissue]ENSG00000101916-TLR8 [tissue]
HPRD02296
Protein Interaction databases
DIP (DOE-UCLA)Q9NR97
IntAct (EBI)Q9NR97
BioGRIDTLR8
STRING (EMBL)TLR8
ZODIACTLR8
Ontologies - Pathways
QuickGOQ9NR97
Ontology : AmiGOGolgi membrane  regulation of protein phosphorylation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  transmembrane signaling receptor activity  endoplasmic reticulum membrane  plasma membrane  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB kinase/NF-kappaB signaling  response to virus  external side of plasma membrane  endosome membrane  integral component of membrane  immunoglobulin mediated immune response  negative regulation of interleukin-12 production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  toll-like receptor 8 signaling pathway  endolysosome membrane  signaling receptor activity  pattern recognition receptor activity  innate immune response  positive regulation of innate immune response  defense response to virus  defense response to virus  defense response to virus  defense response to virus  cellular response to mechanical stimulus  
Ontology : EGO-EBIGolgi membrane  regulation of protein phosphorylation  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  DNA binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  transmembrane signaling receptor activity  endoplasmic reticulum membrane  plasma membrane  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB kinase/NF-kappaB signaling  response to virus  external side of plasma membrane  endosome membrane  integral component of membrane  immunoglobulin mediated immune response  negative regulation of interleukin-12 production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  toll-like receptor 8 signaling pathway  endolysosome membrane  signaling receptor activity  pattern recognition receptor activity  innate immune response  positive regulation of innate immune response  defense response to virus  defense response to virus  defense response to virus  defense response to virus  cellular response to mechanical stimulus  
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTLR8
Atlas of Cancer Signalling NetworkTLR8
Wikipedia pathwaysTLR8
Orthology - Evolution
OrthoDB51311
GeneTree (enSembl)ENSG00000101916
Phylogenetic Trees/Animal Genes : TreeFamTLR8
Homologs : HomoloGeneTLR8
Homology/Alignments : Family Browser (UCSC)TLR8
Gene fusions - Rearrangements
Fusion : QuiverTLR8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR8
dbVarTLR8
ClinVarTLR8
MonarchTLR8
1000_GenomesTLR8 
Exome Variant ServerTLR8
GNOMAD BrowserENSG00000101916
Varsome BrowserTLR8
ACMGTLR8 variants
VarityQ9NR97
Genomic Variants (DGV)TLR8 [DGVbeta]
DECIPHERTLR8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR8 
Mutations
ICGC Data PortalTLR8 
TCGA Data PortalTLR8 
Broad Tumor PortalTLR8
OASIS PortalTLR8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLR8
Mutations and Diseases : HGMDTLR8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLR8
DgiDB (Drug Gene Interaction Database)TLR8
DoCM (Curated mutations)TLR8
CIViC (Clinical Interpretations of Variants in Cancer)TLR8
Cancer3DTLR8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300366   
Orphanet
DisGeNETTLR8
MedgenTLR8
Genetic Testing Registry TLR8
NextProtQ9NR97 [Medical]
GENETestsTLR8
Target ValidationTLR8
Huge Navigator TLR8 [HugePedia]
ClinGenTLR8
Clinical trials, drugs, therapy
MyCancerGenomeTLR8
Protein Interactions : CTDTLR8
Pharm GKB GenePA38009
PharosQ9NR97
Clinical trialTLR8
Miscellaneous
canSAR (ICR)TLR8
HarmonizomeTLR8
DataMed IndexTLR8
Probes
Litterature
PubMed224 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLR8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:35:15 CEST 2021

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