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TLR9 (toll like receptor 9)

Identity

Alias_namestoll-like receptor 9
Alias_symbol (synonym)CD289
Other alias
HGNC (Hugo) TLR9
LocusID (NCBI) 54106
Atlas_Id 46112
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 52221080 and ends at 52226163 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPS20 (8q12.1) / TLR9 (3p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR9   15633
Cards
Entrez_Gene (NCBI)TLR9  54106  toll like receptor 9
AliasesCD289
GeneCards (Weizmann)TLR9
Ensembl hg19 (Hinxton)ENSG00000239732 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239732 [Gene_View]  chr3:52221080-52226163 [Contig_View]  TLR9 [Vega]
ICGC DataPortalENSG00000239732
TCGA cBioPortalTLR9
AceView (NCBI)TLR9
Genatlas (Paris)TLR9
WikiGenes54106
SOURCE (Princeton)TLR9
Genetics Home Reference (NIH)TLR9
Genomic and cartography
GoldenPath hg38 (UCSC)TLR9  -     chr3:52221080-52226163 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR9  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblTLR9 - 3p21.2 [CytoView hg19]  TLR9 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBITLR9 [Mapview hg19]  TLR9 [Mapview hg38]
OMIM605474   
Gene and transcription
Genbank (Entrez)AB045180 AB445673 AF245704 AF246972 AF259262
RefSeq transcript (Entrez)NM_017442 NM_138688
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR9
Cluster EST : UnigeneHs.87968 [ NCBI ]
CGAP (NCI)Hs.87968
Alternative Splicing GalleryENSG00000239732
Gene ExpressionTLR9 [ NCBI-GEO ]   TLR9 [ EBI - ARRAY_EXPRESS ]   TLR9 [ SEEK ]   TLR9 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54106
GTEX Portal (Tissue expression)TLR9
Human Protein AtlasENSG00000239732-TLR9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR96
Splice isoforms : SwissVarQ9NR96
PhosPhoSitePlusQ9NR96
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR9   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13516    pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  TIR (SM00255)  
Conserved Domain (NCBI)TLR9
DMDM Disease mutations54106
Blocks (Seattle)TLR9
SuperfamilyQ9NR96
Human Protein Atlas [tissue]ENSG00000239732-TLR9 [tissue]
Peptide AtlasQ9NR96
HPRD05685
IPIIPI00010140   IPI00219487   IPI00219488   IPI00914987   IPI00219490   IPI00946591   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR96
IntAct (EBI)Q9NR96
FunCoupENSG00000239732
BioGRIDTLR9
STRING (EMBL)TLR9
ZODIACTLR9
Ontologies - Pathways
QuickGOQ9NR96
Ontology : AmiGOGolgi membrane  toll-like receptor signaling pathway  response to molecule of bacterial origin  MyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  interleukin-1 receptor binding  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  lysosome  endosome  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  inflammatory response  I-kappaB phosphorylation  axonogenesis  endosome membrane  positive regulation of gene expression  integral component of membrane  1-phosphatidylinositol-3-kinase activity  basolateral plasma membrane  apical plasma membrane  maintenance of gastrointestinal epithelium  early phagosome  negative regulation of NF-kappaB transcription factor activity  tumor necrosis factor production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-18 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  negative regulation of toll-like receptor signaling pathway  positive regulation of toll-like receptor signaling pathway  toll-like receptor 9 signaling pathway  siRNA binding  endolysosome membrane  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of NF-kappaB import into nucleus  defense response to bacterium  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  positive regulation of interferon-gamma biosynthetic process  innate immune response  unmethylated CpG binding  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  regulation of cytokine secretion  positive regulation of inflammatory response  defense response to Gram-negative bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  negative regulation of calcium-transporting ATPase activity  
Ontology : EGO-EBIGolgi membrane  toll-like receptor signaling pathway  response to molecule of bacterial origin  MyD88-dependent toll-like receptor signaling pathway  transmembrane signaling receptor activity  interleukin-1 receptor binding  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  lysosome  endosome  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  inflammatory response  I-kappaB phosphorylation  axonogenesis  endosome membrane  positive regulation of gene expression  integral component of membrane  1-phosphatidylinositol-3-kinase activity  basolateral plasma membrane  apical plasma membrane  maintenance of gastrointestinal epithelium  early phagosome  negative regulation of NF-kappaB transcription factor activity  tumor necrosis factor production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  positive regulation of chemokine production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-18 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  negative regulation of toll-like receptor signaling pathway  positive regulation of toll-like receptor signaling pathway  toll-like receptor 9 signaling pathway  siRNA binding  endolysosome membrane  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of NF-kappaB import into nucleus  defense response to bacterium  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  positive regulation of interferon-gamma biosynthetic process  innate immune response  unmethylated CpG binding  positive regulation of interferon-alpha biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  regulation of cytokine secretion  positive regulation of inflammatory response  defense response to Gram-negative bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  negative regulation of calcium-transporting ATPase activity  
Pathways : KEGGToll-like receptor signaling pathway    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Malaria    Tuberculosis    Measles    Herpes simplex infection   
NDEx NetworkTLR9
Atlas of Cancer Signalling NetworkTLR9
Wikipedia pathwaysTLR9
Orthology - Evolution
OrthoDB54106
GeneTree (enSembl)ENSG00000239732
Phylogenetic Trees/Animal Genes : TreeFamTLR9
HOVERGENQ9NR96
HOGENOMQ9NR96
Homologs : HomoloGeneTLR9
Homology/Alignments : Family Browser (UCSC)TLR9
Gene fusions - Rearrangements
Tumor Fusion PortalTLR9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR9
dbVarTLR9
ClinVarTLR9
1000_GenomesTLR9 
Exome Variant ServerTLR9
ExAC (Exome Aggregation Consortium)ENSG00000239732
GNOMAD BrowserENSG00000239732
Genetic variants : HAPMAP54106
Genomic Variants (DGV)TLR9 [DGVbeta]
DECIPHERTLR9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR9 
Mutations
ICGC Data PortalTLR9 
TCGA Data PortalTLR9 
Broad Tumor PortalTLR9
OASIS PortalTLR9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TLR9
DgiDB (Drug Gene Interaction Database)TLR9
DoCM (Curated mutations)TLR9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR9 (select a term)
intoGenTLR9
Cancer3DTLR9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605474   
Orphanet
DisGeNETTLR9
MedgenTLR9
Genetic Testing Registry TLR9
NextProtQ9NR96 [Medical]
TSGene54106
GENETestsTLR9
Target ValidationTLR9
Huge Navigator TLR9 [HugePedia]
snp3D : Map Gene to Disease54106
BioCentury BCIQTLR9
ClinGenTLR9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54106
Chemical/Pharm GKB GenePA38010
Clinical trialTLR9
Miscellaneous
canSAR (ICR)TLR9 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR9
EVEXTLR9
GoPubMedTLR9
iHOPTLR9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:38:36 CET 2017

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