Alias (NCBI) | HOX11 |
| TCL3 |
HGNC (Hugo) |
TLX1 |
HGNC Alias name | Homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) |
| homeo box 11 (T-cell lymphoma 3-associated breakpoint) |
HGNC Previous name | TCL3 |
| HOX11 |
HGNC Previous name | homeo box 11 (T-cell lymphoma 3-associated breakpoint) |
| T-cell leukemia, homeobox 1 |
| T-cell leukemia homeobox 1 |
LocusID (NCBI) |
3195 |
Atlas_Id |
31 |
Location |
10q24.31 [Link to chromosome band 10q24] |
Location_base_pair |
Starts at 101131300 and ends at 101137789 bp from pter ( according to hg38-Dec_2013) |
| Nomenclature |
HGNC (Hugo) | TLX1 5056 |
| Cards |
Entrez_Gene (NCBI) | TLX1 T cell leukemia homeobox 1 |
Aliases | HOX11; TCL3 |
GeneCards (Weizmann) | TLX1 |
Ensembl hg19 (Hinxton) | ENSG00000107807 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000107807 [Gene_View]  ENSG00000107807 [Sequence] chr10:101131300-101137789 [Contig_View] TLX1 [Vega] |
ICGC DataPortal | ENSG00000107807 |
TCGA cBioPortal | TLX1 |
AceView (NCBI) | TLX1 |
Genatlas (Paris) | TLX1 |
SOURCE (Princeton) | TLX1 |
Genetics Home Reference (NIH) | TLX1 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | TLX1 - chr10:101131300-101137789 + 10q24.31 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | TLX1 - 10q24.31 [Description] (hg19-Feb_2009) |
GoldenPath | TLX1 - 10q24.31 [CytoView hg19] TLX1 - 10q24.31 [CytoView hg38] |
ImmunoBase | ENSG00000107807 |
genome Data Viewer NCBI | TLX1 [Mapview hg19] |
OMIM | 186770 |
| Gene and transcription |
Genbank (Entrez) | BC130530 BF514683 M62626 M75952 S38742 |
RefSeq transcript (Entrez) | NM_001195517 NM_005521 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | TLX1 |
Alternative Splicing Gallery | ENSG00000107807 |
Gene Expression | TLX1 [ NCBI-GEO ] TLX1 [ EBI - ARRAY_EXPRESS ]
TLX1 [ SEEK ] TLX1 [ MEM ] |
Gene Expression Viewer (FireBrowse) | TLX1 [ Firebrowse - Broad ] |
Genevisible | Expression of TLX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 3195 |
GTEX Portal (Tissue expression) | TLX1 |
Human Protein Atlas | ENSG00000107807-TLX1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P31314 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P31314 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P31314 |
Splice isoforms : SwissVar | P31314 |
PhosPhoSitePlus | P31314 |
Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
Domains : Interpro (EBI) | Homeobox-like_sf Homeobox_CS Homeobox_dom Homeobox_metazoa TLX1/2/3 |
Domain families : Pfam (Sanger) | Homeodomain (PF00046) |
Domain families : Pfam (NCBI) | pfam00046 |
Domain families : Smart (EMBL) | HOX (SM00389) |
Conserved Domain (NCBI) | TLX1 |
Blocks (Seattle) | TLX1 |
Superfamily | P31314 |
Human Protein Atlas [tissue] | ENSG00000107807-TLX1 [tissue] |
Peptide Atlas | P31314 |
HPRD | 01728 |
IPI | IPI00011051 IPI00981206 IPI00983276 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P31314 |
IntAct (EBI) | P31314 |
BioGRID | TLX1 |
STRING (EMBL) | TLX1 |
ZODIAC | TLX1 |
| Ontologies - Pathways |
QuickGO | P31314 |
Ontology : AmiGO | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding nucleus regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II animal organ development |
Ontology : EGO-EBI | nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding nucleus regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II animal organ development |
Pathways : KEGG | Transcriptional misregulation in cancer |
NDEx Network | TLX1 |
Atlas of Cancer Signalling Network | TLX1 |
Wikipedia pathways | TLX1 |
| Orthology - Evolution |
OrthoDB | 3195 |
GeneTree (enSembl) | ENSG00000107807 |
Phylogenetic Trees/Animal Genes : TreeFam | TLX1 |
HOGENOM | P31314 |
Homologs : HomoloGene | TLX1 |
Homology/Alignments : Family Browser (UCSC) | TLX1 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | TRB/TLX1 [-/10q24.31]   |
| |
Fusion : Mitelman | TRD/TLX1 [-/10q24.31]   |
| |
Fusion : Quiver | TLX1 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | TLX1 [hg38] |
dbVar | TLX1 |
ClinVar | TLX1 |
Monarch | TLX1 |
1000_Genomes | TLX1 |
Exome Variant Server | TLX1 |
GNOMAD Browser | ENSG00000107807 |
Varsome Browser | TLX1 |
Genomic Variants (DGV) | TLX1 [DGVbeta] |
DECIPHER | TLX1 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | TLX1 |
| Mutations |
ICGC Data Portal | TLX1 |
TCGA Data Portal | TLX1 |
Broad Tumor Portal | TLX1 |
OASIS Portal | TLX1 [ Somatic mutations - Copy number] |
Cancer Gene: Census | TLX1 |
Somatic Mutations in Cancer : COSMIC | TLX1 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | TLX1 |
Mutations and Diseases : HGMD | TLX1 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search TLX1 |
DgiDB (Drug Gene Interaction Database) | TLX1 |
DoCM (Curated mutations) | TLX1 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | TLX1 (select a term) |
intoGen | TLX1 |
Cancer3D | TLX1(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 186770 |
Orphanet | 14434 |
DisGeNET | TLX1 |
Medgen | TLX1 |
Genetic Testing Registry | TLX1
|
NextProt | P31314 [Medical] |
GENETests | TLX1 |
Target Validation | TLX1 |
Huge Navigator |
TLX1 [HugePedia] |
ClinGen | TLX1 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | TLX1 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA35095 |
Pharos | P31314 |
Clinical trial | TLX1 |
| Miscellaneous |
---|
canSAR (ICR) | TLX1 (select the gene name) |
Harmonizome | TLX1 |
DataMed Index | TLX1 |
| Probes |
---|
| Litterature |
---|
PubMed | 46 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | TLX1 |