| Nomenclature |
|---|
| HGNC (Hugo) | TLX1 5056 |
| Cards |
|---|
| Entrez_Gene (NCBI) | TLX1 3195 T cell leukemia homeobox 1 |
| Aliases | HOX11; TCL3 |
| GeneCards (Weizmann) | TLX1 |
| Ensembl hg19 (Hinxton) | ENSG00000107807 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000107807 [Gene_View] ENSG00000107807 [Sequence] chr10:101131304-101137789 [Contig_View] TLX1 [Vega] |
| ICGC DataPortal | ENSG00000107807 |
| TCGA cBioPortal | TLX1 |
| AceView (NCBI) | TLX1 |
| Genatlas (Paris) | TLX1 |
| WikiGenes | 3195 |
| SOURCE (Princeton) | TLX1 |
| Genetics Home Reference (NIH) | TLX1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | TLX1 - chr10:101131304-101137789 + 3p21.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | TLX1 - 3p21.2 [Description] (hg19-Feb_2009) |
| Ensembl | TLX1 - 3p21.2 [CytoView hg19] TLX1 - 3p21.2 [CytoView hg38] |
| Mapping of homologs : NCBI | TLX1 [Mapview hg19] TLX1 [Mapview hg38] |
| OMIM | 186770 |
| Gene and transcription |
|---|
| Genbank (Entrez) | BC130530 BF514683 M62626 M75952 S38742 |
| RefSeq transcript (Entrez) | NM_001195517 NM_005521 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | TLX1 |
| Cluster EST : Unigene | Hs.89583 [ NCBI ] |
| CGAP (NCI) | Hs.89583 |
| Alternative Splicing Gallery | ENSG00000107807 |
| Gene Expression | TLX1 [ NCBI-GEO ] TLX1 [ EBI - ARRAY_EXPRESS ]
TLX1 [ SEEK ] TLX1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | TLX1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3195 |
| GTEX Portal (Tissue expression) | TLX1 |
| Human Protein Atlas | ENSG00000107807-TLX1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P31314 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P31314 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P31314 |
| Splice isoforms : SwissVar | P31314 |
| PhosPhoSitePlus | P31314 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Homeobox-like_sf Homeobox_CS Homeobox_dom Homeobox_metazoa |
| Domain families : Pfam (Sanger) | Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| Conserved Domain (NCBI) | TLX1 |
| DMDM Disease mutations | 3195 |
| Blocks (Seattle) | TLX1 |
| Superfamily | P31314 |
| Human Protein Atlas [tissue] | ENSG00000107807-TLX1 [tissue] |
| Peptide Atlas | P31314 |
| HPRD | 01728 |
| IPI | IPI00011051 IPI00981206 IPI00983276 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P31314 |
| IntAct (EBI) | P31314 |
| FunCoup | ENSG00000107807 |
| BioGRID | TLX1 |
| STRING (EMBL) | TLX1 |
| ZODIAC | TLX1 |
| Ontologies - Pathways |
|---|
| QuickGO | P31314 |
| Ontology : AmiGO | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding protein binding nucleus transcription by RNA polymerase II multicellular organism development positive regulation of transcription by RNA polymerase II |
| Ontology : EGO-EBI | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding protein binding nucleus transcription by RNA polymerase II multicellular organism development positive regulation of transcription by RNA polymerase II |
| Pathways : KEGG | Transcriptional misregulation in cancer |
| NDEx Network | TLX1 |
| Atlas of Cancer Signalling Network | TLX1 |
| Wikipedia pathways | TLX1 |
| Orthology - Evolution |
|---|
| OrthoDB | 3195 |
| GeneTree (enSembl) | ENSG00000107807 |
| Phylogenetic Trees/Animal Genes : TreeFam | TLX1 |
| HOVERGEN | P31314 |
| HOGENOM | P31314 |
| Homologs : HomoloGene | TLX1 |
| Homology/Alignments : Family Browser (UCSC) | TLX1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | TRB/TLX1 [-/10q24.31] [t(10;14)(q24;q11)] [t(7;10)(q34;q24)] |
| |
| Fusion : Mitelman | TRD/TLX1 [-/10q24.31] [t(10;14)(q24;q11)] [t(7;10)(q34;q24)] |
| |
| Fusion : Quiver | TLX1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | TLX1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | TLX1 |
| dbVar | TLX1 |
| ClinVar | TLX1 |
| 1000_Genomes | TLX1 |
| Exome Variant Server | TLX1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000107807 |
| GNOMAD Browser | ENSG00000107807 |
| Varsome Browser | TLX1 |
| Genetic variants : HAPMAP | 3195 |
| Genomic Variants (DGV) | TLX1 [DGVbeta] |
| DECIPHER | TLX1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | TLX1 |
| Mutations |
|---|
| ICGC Data Portal | TLX1 |
| TCGA Data Portal | TLX1 |
| Broad Tumor Portal | TLX1 |
| OASIS Portal | TLX1 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | TLX1 |
| Somatic Mutations in Cancer : COSMIC | TLX1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | TLX1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search TLX1 |
| DgiDB (Drug Gene Interaction Database) | TLX1 |
| DoCM (Curated mutations) | TLX1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | TLX1 (select a term) |
| intoGen | TLX1 |
| Cancer3D | TLX1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 186770 |
| Orphanet | 14434 |
| DisGeNET | TLX1 |
| Medgen | TLX1 |
| Genetic Testing Registry | TLX1
|
| NextProt | P31314 [Medical] |
| TSGene | 3195 |
| GENETests | TLX1 |
| Target Validation | TLX1 |
| Huge Navigator |
TLX1 [HugePedia] |
| snp3D : Map Gene to Disease | 3195 |
| BioCentury BCIQ | TLX1 |
| ClinGen | TLX1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 3195 |
| Chemical/Pharm GKB Gene | PA35095 |
| Clinical trial | TLX1 |
| Miscellaneous |
|---|
| canSAR (ICR) | TLX1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 41 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | TLX1 |
| EVEX | TLX1 |
| GoPubMed | TLX1 |
| iHOP | TLX1 |
