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TLX1 (T cell leukemia homeobox 1)

Identity

Alias_namesTCL3
HOX11
homeo box 11 (T-cell lymphoma 3-associated breakpoint)
T-cell leukemia, homeobox 1
T-cell leukemia homeobox 1
Other alias
HGNC (Hugo) TLX1
LocusID (NCBI) 3195
Atlas_Id 31
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 101131304 and ends at 101137789 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TLX1 (10q24.31) / TLX1 (10q24.31)TLX1 (10q24.31) / TRA ()TLX1 (10q24.31) / TRB ()
TLX1 (10q24.31) / TRBV20OR9-2 ()TLX1 (10q24.31) / TRD ()TRA () / TLX1 (10q24.31)
TRB () / TLX1 (10q24.31)TRD () / TLX1 (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 1014ID1068 PediatrTCellALLID1292 TL_t0710q34q24ID3261 TL_t0710q34q24ID3292 TL_t1010q23q24ID2923
TL_t1014q24q11ID3260 TL_t1014q24q11ID3283

External links

Nomenclature
HGNC (Hugo)TLX1   5056
Cards
Entrez_Gene (NCBI)TLX1  3195  T cell leukemia homeobox 1
AliasesHOX11; TCL3
GeneCards (Weizmann)TLX1
Ensembl hg19 (Hinxton)ENSG00000107807 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107807 [Gene_View]  ENSG00000107807 [Sequence]  chr10:101131304-101137789 [Contig_View]  TLX1 [Vega]
ICGC DataPortalENSG00000107807
TCGA cBioPortalTLX1
AceView (NCBI)TLX1
Genatlas (Paris)TLX1
WikiGenes3195
SOURCE (Princeton)TLX1
Genetics Home Reference (NIH)TLX1
Genomic and cartography
GoldenPath hg38 (UCSC)TLX1  -     chr10:101131304-101137789 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLX1  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathTLX1 - 10q24.31 [CytoView hg19]  TLX1 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000107807
Mapping of homologs : NCBITLX1 [Mapview hg19]  TLX1 [Mapview hg38]
OMIM186770   
Gene and transcription
Genbank (Entrez)BC130530 BF514683 M62626 M75952 S38742
RefSeq transcript (Entrez)NM_001195517 NM_005521
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLX1
Alternative Splicing GalleryENSG00000107807
Gene ExpressionTLX1 [ NCBI-GEO ]   TLX1 [ EBI - ARRAY_EXPRESS ]   TLX1 [ SEEK ]   TLX1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3195
GTEX Portal (Tissue expression)TLX1
Human Protein AtlasENSG00000107807-TLX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TLX1
DMDM Disease mutations3195
Blocks (Seattle)TLX1
Human Protein Atlas [tissue]ENSG00000107807-TLX1 [tissue]
HPRD01728
IPIIPI00011051   IPI00981206   IPI00983276   
Protein Interaction databases
FunCoupENSG00000107807
BioGRIDTLX1
STRING (EMBL)TLX1
ZODIACTLX1
Ontologies - Pathways
Huge Navigator TLX1 [HugePedia]
snp3D : Map Gene to Disease3195
BioCentury BCIQTLX1
ClinGenTLX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3195
Chemical/Pharm GKB GenePA35095
Clinical trialTLX1
Miscellaneous
canSAR (ICR)TLX1 (select the gene name)
DataMed IndexTLX1
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLX1
EVEXTLX1
GoPubMedTLX1
iHOPTLX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 17:13:08 CET 2020
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