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TLX1 (T cell leukemia homeobox 1)

Identity

Alias (NCBI)HOX11
TCL3
HGNC (Hugo) TLX1
HGNC Alias nameHomeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
 homeo box 11 (T-cell lymphoma 3-associated breakpoint)
HGNC Previous nameTCL3
 HOX11
HGNC Previous namehomeo box 11 (T-cell lymphoma 3-associated breakpoint)
 T-cell leukemia, homeobox 1
 T-cell leukemia homeobox 1
LocusID (NCBI) 3195
Atlas_Id 31
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 101131300 and ends at 101137789 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TLX1 (10q24.31) / TLX1 (10q24.31)TLX1 (10q24.31) / TRA ()TLX1 (10q24.31) / TRB ()
TLX1 (10q24.31) / TRBV20OR9-2 ()TLX1 (10q24.31) / TRD ()TRA () / TLX1 (10q24.31)
TRB () / TLX1 (10q24.31)TRD () / TLX1 (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 14 ]
  t(10;14)(q24;q11) TLX1/TRD::t(7;10)(q34;q24) TRB/HOX11
NUP214/ABL1 fusion gene on amplified episomes
Pediatric T-Cell Acute Lymphoblastic Leukemia
t(5;7)(q35;q21) TLX3/CDK6
t(5;14)(q35;q32.2) BCL11B/TLX3 and NKX2-5
t(7;14)(q34;q11) TRA/TRB
t(7;14)(q34;q11) TRA/TRB
t(7;19)(q34;p13) TRB/LYL1
t(9;14)(q34;q32) EML1/ABL1
t(10;14)(q24;q32) NFKB2/IGH
T-lineage acute lymphoblastic leukemia (T-ALL)
t(7;10)(q34;q24) TLX1/TRB
t(10;10)(q23;q24) LINC00502/TLX1
t(10;14)(q24;q11) TLX1/TRA

External links

 

Nomenclature
HGNC (Hugo)TLX1   5056
Cards
Entrez_Gene (NCBI)TLX1    T cell leukemia homeobox 1
AliasesHOX11; TCL3
GeneCards (Weizmann)TLX1
Ensembl hg19 (Hinxton)ENSG00000107807 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107807 [Gene_View]  ENSG00000107807 [Sequence]  chr10:101131300-101137789 [Contig_View]  TLX1 [Vega]
ICGC DataPortalENSG00000107807
TCGA cBioPortalTLX1
AceView (NCBI)TLX1
Genatlas (Paris)TLX1
SOURCE (Princeton)TLX1
Genetics Home Reference (NIH)TLX1
Genomic and cartography
GoldenPath hg38 (UCSC)TLX1  -     chr10:101131300-101137789 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLX1  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathTLX1 - 10q24.31 [CytoView hg19]  TLX1 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000107807
Genome Data Viewer NCBITLX1 [Mapview hg19]  
OMIM186770   
Gene and transcription
Genbank (Entrez)BC130530 BF514683 M62626 M75952 S38742
RefSeq transcript (Entrez)NM_001195517 NM_005521
Consensus coding sequences : CCDS (NCBI)TLX1
Gene ExpressionTLX1 [ NCBI-GEO ]   TLX1 [ EBI - ARRAY_EXPRESS ]   TLX1 [ SEEK ]   TLX1 [ MEM ]
Gene Expression Viewer (FireBrowse)TLX1 [ Firebrowse - Broad ]
GenevisibleExpression of TLX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3195
GTEX Portal (Tissue expression)TLX1
Human Protein AtlasENSG00000107807-TLX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31314   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31314  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31314
PhosPhoSitePlusP31314
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    TLX1/2/3   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)TLX1
SuperfamilyP31314
AlphaFold pdb e-kbP31314   
Human Protein Atlas [tissue]ENSG00000107807-TLX1 [tissue]
HPRD01728
Protein Interaction databases
DIP (DOE-UCLA)P31314
IntAct (EBI)P31314
BioGRIDTLX1
STRING (EMBL)TLX1
ZODIACTLX1
Ontologies - Pathways
QuickGOP31314
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  animal organ development  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  animal organ development  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkTLX1
Atlas of Cancer Signalling NetworkTLX1
Wikipedia pathwaysTLX1
Orthology - Evolution
OrthoDB3195
GeneTree (enSembl)ENSG00000107807
Phylogenetic Trees/Animal Genes : TreeFamTLX1
Homologs : HomoloGeneTLX1
Homology/Alignments : Family Browser (UCSC)TLX1
Gene fusions - Rearrangements
Fusion : MitelmanTRB/TLX1 [-/10q24.31]  
Fusion : MitelmanTRD/TLX1 [-/10q24.31]  
Fusion : QuiverTLX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLX1
dbVarTLX1
ClinVarTLX1
MonarchTLX1
1000_GenomesTLX1 
Exome Variant ServerTLX1
GNOMAD BrowserENSG00000107807
Varsome BrowserTLX1
ACMGTLX1 variants
VarityP31314
Genomic Variants (DGV)TLX1 [DGVbeta]
DECIPHERTLX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLX1 
Mutations
ICGC Data PortalTLX1 
TCGA Data PortalTLX1 
Broad Tumor PortalTLX1
OASIS PortalTLX1 [ Somatic mutations - Copy number]
Cancer Gene: CensusTLX1 
Somatic Mutations in Cancer : COSMICTLX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLX1
Mutations and Diseases : HGMDTLX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTLX1
DgiDB (Drug Gene Interaction Database)TLX1
DoCM (Curated mutations)TLX1
CIViC (Clinical Interpretations of Variants in Cancer)TLX1
Cancer3DTLX1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186770   
Orphanet14434   
DisGeNETTLX1
MedgenTLX1
Genetic Testing Registry TLX1
NextProtP31314 [Medical]
GENETestsTLX1
Target ValidationTLX1
Huge Navigator TLX1 [HugePedia]
ClinGenTLX1
Clinical trials, drugs, therapy
MyCancerGenomeTLX1
Protein Interactions : CTDTLX1
Pharm GKB GenePA35095
PharosP31314
Clinical trialTLX1
Miscellaneous
canSAR (ICR)TLX1
HarmonizomeTLX1
DataMed IndexTLX1
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTLX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:16 CEST 2021
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