TLX2 (T cell leukemia homeobox 2)

2003-12-01 Affiliation

Identity

HGNC

TLX2

LOCATION

2p13.1

LOCUSID

3196

ALIAS

HOX11L1,NCX

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3196
MIM: 604240
HGNC: 5057
Ensembl: ENSG00000115297

Variants:

dbSNP: 3196
ClinVar: 3196
TCGA: ENSG00000115297
COSMIC: TLX2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115297	ENST00000233638	O43763
ENSG00000115297	ENST00000621092	F1T0F2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19719399	2010	Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes.	37
16402914	2006	The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.	11
20728215	2010	Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.	9
10446220	1999	An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells.	2
16969514	2006	Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.	2
16291166	2005	Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.	0
20044949	2009	Functional characterization of a minimal sequence essential for the expression of human TLX2 gene.	0

Citation

Dessen P

TLX2 (T cell leukemia homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42582/tlx2