Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TLX2 (T cell leukemia homeobox 2)

Identity

Alias (NCBI)HOX11L1
NCX
HGNC (Hugo) TLX2
HGNC Alias symbEnx
Tlx2
NCX
HGNC Previous nameHOX11L1
HGNC Previous namehomeo box 11-like 1
 T-cell leukemia, homeobox 2
 T-cell leukemia homeobox 2
LocusID (NCBI) 3196
Atlas_Id 42582
Location 2p13.1  [Link to chromosome band 2p13]
Location_base_pair Starts at 74514450 and ends at 74517148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TLX2   5057
Cards
Entrez_Gene (NCBI)TLX2  3196  T cell leukemia homeobox 2
AliasesHOX11L1; NCX
GeneCards (Weizmann)TLX2
Ensembl hg19 (Hinxton)ENSG00000115297 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115297 [Gene_View]  ENSG00000115297 [Sequence]  chr2:74514450-74517148 [Contig_View]  TLX2 [Vega]
ICGC DataPortalENSG00000115297
TCGA cBioPortalTLX2
AceView (NCBI)TLX2
Genatlas (Paris)TLX2
WikiGenes3196
SOURCE (Princeton)TLX2
Genetics Home Reference (NIH)TLX2
Genomic and cartography
GoldenPath hg38 (UCSC)TLX2  -     chr2:74514450-74517148 +  2p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLX2  -     2p13.1   [Description]    (hg19-Feb_2009)
GoldenPathTLX2 - 2p13.1 [CytoView hg19]  TLX2 - 2p13.1 [CytoView hg38]
ImmunoBaseENSG00000115297
genome Data Viewer NCBITLX2 [Mapview hg19]  
OMIM604240   
Gene and transcription
Genbank (Entrez)AB008501 AB593086 BC006356 BC006396 BC018611
RefSeq transcript (Entrez)NM_016170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLX2
Alternative Splicing GalleryENSG00000115297
Gene ExpressionTLX2 [ NCBI-GEO ]   TLX2 [ EBI - ARRAY_EXPRESS ]   TLX2 [ SEEK ]   TLX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TLX2 [ Firebrowse - Broad ]
GenevisibleExpression of TLX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3196
GTEX Portal (Tissue expression)TLX2
Human Protein AtlasENSG00000115297-TLX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43763   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43763
Splice isoforms : SwissVarO43763
PhosPhoSitePlusO43763
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    TLX1/2/3   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)TLX2
DMDM Disease mutations3196
Blocks (Seattle)TLX2
PDB (RSDB)3A03   
PDB Europe3A03   
PDB (PDBSum)3A03   
PDB (IMB)3A03   
Structural Biology KnowledgeBase3A03   
SCOP (Structural Classification of Proteins)3A03   
CATH (Classification of proteins structures)3A03   
SuperfamilyO43763
Human Protein Atlas [tissue]ENSG00000115297-TLX2 [tissue]
Peptide AtlasO43763
HPRD07254
IPIIPI00013948   IPI01022345   
Protein Interaction databases
DIP (DOE-UCLA)O43763
IntAct (EBI)O43763
FunCoupENSG00000115297
BioGRIDTLX2
STRING (EMBL)TLX2
ZODIACTLX2
Ontologies - Pathways
QuickGOO43763
Ontology : AmiGOnuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  mesoderm formation  cellular_component  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  enteric nervous system development  animal organ development  negative regulation of dendrite morphogenesis  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  mesoderm formation  cellular_component  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  enteric nervous system development  animal organ development  negative regulation of dendrite morphogenesis  
NDEx NetworkTLX2
Atlas of Cancer Signalling NetworkTLX2
Wikipedia pathwaysTLX2
Orthology - Evolution
OrthoDB3196
GeneTree (enSembl)ENSG00000115297
Phylogenetic Trees/Animal Genes : TreeFamTLX2
HOGENOMO43763
Homologs : HomoloGeneTLX2
Homology/Alignments : Family Browser (UCSC)TLX2
Gene fusions - Rearrangements
Fusion : QuiverTLX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLX2
dbVarTLX2
ClinVarTLX2
MonarchTLX2
1000_GenomesTLX2 
Exome Variant ServerTLX2
GNOMAD BrowserENSG00000115297
Varsome BrowserTLX2
Genetic variants : HAPMAP3196
Genomic Variants (DGV)TLX2 [DGVbeta]
DECIPHERTLX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLX2 
Mutations
ICGC Data PortalTLX2 
TCGA Data PortalTLX2 
Broad Tumor PortalTLX2
OASIS PortalTLX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTLX2
Mutations and Diseases : HGMDTLX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TLX2
DgiDB (Drug Gene Interaction Database)TLX2
DoCM (Curated mutations)TLX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLX2 (select a term)
intoGenTLX2
Cancer3DTLX2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604240   
Orphanet
DisGeNETTLX2
MedgenTLX2
Genetic Testing Registry TLX2
NextProtO43763 [Medical]
TSGene3196
GENETestsTLX2
Target ValidationTLX2
Huge Navigator TLX2 [HugePedia]
snp3D : Map Gene to Disease3196
BioCentury BCIQTLX2
ClinGenTLX2
Clinical trials, drugs, therapy
Protein Interactions : CTD3196
Pharm GKB GenePA35096
Clinical trialTLX2
Miscellaneous
canSAR (ICR)TLX2 (select the gene name)
HarmonizomeTLX2
DataMed IndexTLX2
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLX2
EVEXTLX2
GoPubMedTLX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:36:15 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.