Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TMC3 (transmembrane channel like 3)

Identity

Alias (NCBI)-
HGNC (Hugo) TMC3
LocusID (NCBI) 342125
Atlas_Id 74744
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 81331088 and ends at 81374213 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMC3   22995
Cards
Entrez_Gene (NCBI)TMC3    transmembrane channel like 3
Aliases
GeneCards (Weizmann)TMC3
Ensembl hg19 (Hinxton)ENSG00000188869 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188869 [Gene_View]  ENSG00000188869 [Sequence]  chr15:81331088-81374213 [Contig_View]  TMC3 [Vega]
ICGC DataPortalENSG00000188869
TCGA cBioPortalTMC3
AceView (NCBI)TMC3
Genatlas (Paris)TMC3
SOURCE (Princeton)TMC3
Genetics Home Reference (NIH)TMC3
Genomic and cartography
GoldenPath hg38 (UCSC)TMC3  -     chr15:81331088-81374213 -  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMC3  -     15q25.1   [Description]    (hg19-Feb_2009)
GoldenPathTMC3 - 15q25.1 [CytoView hg19]  TMC3 - 15q25.1 [CytoView hg38]
ImmunoBaseENSG00000188869
Genome Data Viewer NCBITMC3 [Mapview hg19]  
OMIM617196   
Gene and transcription
Genbank (Entrez)AY236490 AY263163 BC132679 BC143410 BC157874
RefSeq transcript (Entrez)NM_001080532 NM_181841
Consensus coding sequences : CCDS (NCBI)TMC3
Gene ExpressionTMC3 [ NCBI-GEO ]   TMC3 [ EBI - ARRAY_EXPRESS ]   TMC3 [ SEEK ]   TMC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TMC3 [ Firebrowse - Broad ]
GenevisibleExpression of TMC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)342125
GTEX Portal (Tissue expression)TMC3
Human Protein AtlasENSG00000188869-TMC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5M5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5M5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5M5
PhosPhoSitePlusQ7Z5M5
Domains : Interpro (EBI)TMC    TMC_dom   
Domain families : Pfam (Sanger)TMC (PF07810)   
Domain families : Pfam (NCBI)pfam07810   
Conserved Domain (NCBI)TMC3
SuperfamilyQ7Z5M5
AlphaFold pdb e-kbQ7Z5M5   
Human Protein Atlas [tissue]ENSG00000188869-TMC3 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5M5
IntAct (EBI)Q7Z5M5
BioGRIDTMC3
STRING (EMBL)TMC3
ZODIACTMC3
Ontologies - Pathways
QuickGOQ7Z5M5
Ontology : AmiGOintegral component of plasma membrane  mechanosensitive ion channel activity  ion transmembrane transport  
Ontology : EGO-EBIintegral component of plasma membrane  mechanosensitive ion channel activity  ion transmembrane transport  
NDEx NetworkTMC3
Atlas of Cancer Signalling NetworkTMC3
Wikipedia pathwaysTMC3
Orthology - Evolution
OrthoDB342125
GeneTree (enSembl)ENSG00000188869
Phylogenetic Trees/Animal Genes : TreeFamTMC3
Homologs : HomoloGeneTMC3
Homology/Alignments : Family Browser (UCSC)TMC3
Gene fusions - Rearrangements
Fusion : QuiverTMC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMC3
dbVarTMC3
ClinVarTMC3
MonarchTMC3
1000_GenomesTMC3 
Exome Variant ServerTMC3
GNOMAD BrowserENSG00000188869
Varsome BrowserTMC3
ACMGTMC3 variants
VarityQ7Z5M5
Genomic Variants (DGV)TMC3 [DGVbeta]
DECIPHERTMC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMC3 
Mutations
ICGC Data PortalTMC3 
TCGA Data PortalTMC3 
Broad Tumor PortalTMC3
OASIS PortalTMC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMC3
Mutations and Diseases : HGMDTMC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMC3
DgiDB (Drug Gene Interaction Database)TMC3
DoCM (Curated mutations)TMC3
CIViC (Clinical Interpretations of Variants in Cancer)TMC3
Cancer3DTMC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617196   
Orphanet
DisGeNETTMC3
MedgenTMC3
Genetic Testing Registry TMC3
NextProtQ7Z5M5 [Medical]
GENETestsTMC3
Target ValidationTMC3
Huge Navigator TMC3 [HugePedia]
ClinGenTMC3
Clinical trials, drugs, therapy
MyCancerGenomeTMC3
Protein Interactions : CTDTMC3
Pharm GKB GenePA134916179
PharosQ7Z5M5
Clinical trialTMC3
Miscellaneous
canSAR (ICR)TMC3
HarmonizomeTMC3
DataMed IndexTMC3
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:25:39 CEST 2021

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