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TMC4 (transmembrane channel-like 4)

Identity

Other alias-
HGNC (Hugo) TMC4
LocusID (NCBI) 147798
Atlas_Id 74745
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54663833 and ends at 54676944 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
INTS1 (7p22.3) / TMC4 (19q13.42)KLF5 (13q22.1) / TMC4 (19q13.42)PCDH11X (Xq21.31) / TMC4 (19q13.42)
TMC4 (19q13.42) / COQ5 (12q24.31)TMC4 (19q13.42) / GTF3C5 (9q34.2)TMC4 (19q13.42) / MBOAT7 (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMC4   22998
Cards
Entrez_Gene (NCBI)TMC4  147798  transmembrane channel-like 4
Aliases
GeneCards (Weizmann)TMC4
Ensembl hg19 (Hinxton)ENSG00000167608 [Gene_View]  chr19:54663833-54676944 [Contig_View]  TMC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167608 [Gene_View]  chr19:54663833-54676944 [Contig_View]  TMC4 [Vega]
ICGC DataPortalENSG00000167608
TCGA cBioPortalTMC4
AceView (NCBI)TMC4
Genatlas (Paris)TMC4
WikiGenes147798
SOURCE (Princeton)TMC4
Genetics Home Reference (NIH)TMC4
Genomic and cartography
GoldenPath hg19 (UCSC)TMC4  -     chr19:54663833-54676944 -  19q13.42   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMC4  -     19q13.42   [Description]    (hg38-Dec_2013)
EnsemblTMC4 - 19q13.42 [CytoView hg19]  TMC4 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBITMC4 [Mapview hg19]  TMC4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA578987 AK124406 AK314973 AY236492 AY263166
RefSeq transcript (Entrez)NM_001145303 NM_144686
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NT_187693 NW_003571054 NW_003571055 NW_003571056 NW_003571057 NW_003571058 NW_003571059 NW_003571060 NW_003571061 NW_004929415
Consensus coding sequences : CCDS (NCBI)TMC4
Cluster EST : UnigeneHs.355126 [ NCBI ]
CGAP (NCI)Hs.355126
Alternative Splicing GalleryENSG00000167608
Gene ExpressionTMC4 [ NCBI-GEO ]   TMC4 [ EBI - ARRAY_EXPRESS ]   TMC4 [ SEEK ]   TMC4 [ MEM ]
Gene Expression Viewer (FireBrowse)TMC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147798
GTEX Portal (Tissue expression)TMC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z404   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z404  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z404
Splice isoforms : SwissVarQ7Z404
PhosPhoSitePlusQ7Z404
Domains : Interpro (EBI)TMC   
Domain families : Pfam (Sanger)TMC (PF07810)   
Domain families : Pfam (NCBI)pfam07810   
Conserved Domain (NCBI)TMC4
DMDM Disease mutations147798
Blocks (Seattle)TMC4
SuperfamilyQ7Z404
Human Protein AtlasENSG00000167608
Peptide AtlasQ7Z404
HPRD15515
IPIIPI00657918   IPI00465243   IPI00893396   IPI00893386   IPI00853315   IPI00847304   IPI00892736   IPI00926975   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z404
IntAct (EBI)Q7Z404
FunCoupENSG00000167608
BioGRIDTMC4
STRING (EMBL)TMC4
ZODIACTMC4
Ontologies - Pathways
QuickGOQ7Z404
Ontology : AmiGOion transport  integral component of membrane  extracellular exosome  
Ontology : EGO-EBIion transport  integral component of membrane  extracellular exosome  
NDEx NetworkTMC4
Atlas of Cancer Signalling NetworkTMC4
Wikipedia pathwaysTMC4
Orthology - Evolution
OrthoDB147798
GeneTree (enSembl)ENSG00000167608
Phylogenetic Trees/Animal Genes : TreeFamTMC4
HOVERGENQ7Z404
HOGENOMQ7Z404
Homologs : HomoloGeneTMC4
Homology/Alignments : Family Browser (UCSC)TMC4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMC4
dbVarTMC4
ClinVarTMC4
1000_GenomesTMC4 
Exome Variant ServerTMC4
ExAC (Exome Aggregation Consortium)TMC4 (select the gene name)
Genetic variants : HAPMAP147798
Genomic Variants (DGV)TMC4 [DGVbeta]
DECIPHER (Syndromes)19:54663833-54676944  ENSG00000167608
CONAN: Copy Number AnalysisTMC4 
Mutations
ICGC Data PortalTMC4 
TCGA Data PortalTMC4 
Broad Tumor PortalTMC4
OASIS PortalTMC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMC4
DgiDB (Drug Gene Interaction Database)TMC4
DoCM (Curated mutations)TMC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMC4 (select a term)
intoGenTMC4
Cancer3DTMC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMC4
Genetic Testing Registry TMC4
NextProtQ7Z404 [Medical]
TSGene147798
GENETestsTMC4
Huge Navigator TMC4 [HugePedia]
snp3D : Map Gene to Disease147798
BioCentury BCIQTMC4
ClinGenTMC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147798
Chemical/Pharm GKB GenePA134874063
Clinical trialTMC4
Miscellaneous
canSAR (ICR)TMC4 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMC4
EVEXTMC4
GoPubMedTMC4
iHOPTMC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:48:17 CET 2017

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