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TMC5 (transmembrane channel like 5)

Identity

Alias (NCBI)-
HGNC (Hugo) TMC5
HGNC Alias symbFLJ13593
LocusID (NCBI) 79838
Atlas_Id 74746
Location 16p12.3  [Link to chromosome band 16p12]
Location_base_pair Starts at 19456461 and ends at 19499112 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C16orf62 (16p12.3) / TMC5 (16p12.3)COL12A1 (6q13) / TMC5 (16p12.3)LRRC29 (16q22.1) / TMC5 (16p12.3)
MALAT1 (11q13.1) / TMC5 (16p12.3)TMC5 (16p12.3) / CCP110 (16p12.3)TMC5 (16p12.3) / TMC5 (16p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMC5   22999
Cards
Entrez_Gene (NCBI)TMC5    transmembrane channel like 5
Aliases
GeneCards (Weizmann)TMC5
Ensembl hg19 (Hinxton)ENSG00000103534 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103534 [Gene_View]  ENSG00000103534 [Sequence]  chr16:19456461-19499112 [Contig_View]  TMC5 [Vega]
ICGC DataPortalENSG00000103534
TCGA cBioPortalTMC5
AceView (NCBI)TMC5
Genatlas (Paris)TMC5
SOURCE (Princeton)TMC5
Genetics Home Reference (NIH)TMC5
Genomic and cartography
GoldenPath hg38 (UCSC)TMC5  -     chr16:19456461-19499112 +  16p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMC5  -     16p12.3   [Description]    (hg19-Feb_2009)
GoldenPathTMC5 - 16p12.3 [CytoView hg19]  TMC5 - 16p12.3 [CytoView hg38]
ImmunoBaseENSG00000103534
Genome Data Viewer NCBITMC5 [Mapview hg19]  
OMIM617197   
Gene and transcription
Genbank (Entrez)AI738488 AK023655 AK093944 AK097718 AK131202
RefSeq transcript (Entrez)NM_001105248 NM_001105249 NM_001261841 NM_001308161 NM_024780
Consensus coding sequences : CCDS (NCBI)TMC5
Gene ExpressionTMC5 [ NCBI-GEO ]   TMC5 [ EBI - ARRAY_EXPRESS ]   TMC5 [ SEEK ]   TMC5 [ MEM ]
Gene Expression Viewer (FireBrowse)TMC5 [ Firebrowse - Broad ]
GenevisibleExpression of TMC5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79838
GTEX Portal (Tissue expression)TMC5
Human Protein AtlasENSG00000103534-TMC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXY8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXY8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXY8
PhosPhoSitePlusQ6UXY8
Domains : Interpro (EBI)TMC    TMC_dom   
Domain families : Pfam (Sanger)TMC (PF07810)   
Domain families : Pfam (NCBI)pfam07810   
Conserved Domain (NCBI)TMC5
SuperfamilyQ6UXY8
AlphaFold pdb e-kbQ6UXY8   
Human Protein Atlas [tissue]ENSG00000103534-TMC5 [tissue]
HPRD15516
Protein Interaction databases
DIP (DOE-UCLA)Q6UXY8
IntAct (EBI)Q6UXY8
BioGRIDTMC5
STRING (EMBL)TMC5
ZODIACTMC5
Ontologies - Pathways
QuickGOQ6UXY8
Ontology : AmiGOintegral component of plasma membrane  mechanosensitive ion channel activity  ion transmembrane transport  extracellular exosome  
Ontology : EGO-EBIintegral component of plasma membrane  mechanosensitive ion channel activity  ion transmembrane transport  extracellular exosome  
NDEx NetworkTMC5
Atlas of Cancer Signalling NetworkTMC5
Wikipedia pathwaysTMC5
Orthology - Evolution
OrthoDB79838
GeneTree (enSembl)ENSG00000103534
Phylogenetic Trees/Animal Genes : TreeFamTMC5
Homologs : HomoloGeneTMC5
Homology/Alignments : Family Browser (UCSC)TMC5
Gene fusions - Rearrangements
Fusion : QuiverTMC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMC5
dbVarTMC5
ClinVarTMC5
MonarchTMC5
1000_GenomesTMC5 
Exome Variant ServerTMC5
GNOMAD BrowserENSG00000103534
Varsome BrowserTMC5
ACMGTMC5 variants
VarityQ6UXY8
Genomic Variants (DGV)TMC5 [DGVbeta]
DECIPHERTMC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMC5 
Mutations
ICGC Data PortalTMC5 
TCGA Data PortalTMC5 
Broad Tumor PortalTMC5
OASIS PortalTMC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMC5
Mutations and Diseases : HGMDTMC5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMC5
DgiDB (Drug Gene Interaction Database)TMC5
DoCM (Curated mutations)TMC5
CIViC (Clinical Interpretations of Variants in Cancer)TMC5
Cancer3DTMC5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617197   
Orphanet
DisGeNETTMC5
MedgenTMC5
Genetic Testing Registry TMC5
NextProtQ6UXY8 [Medical]
GENETestsTMC5
Target ValidationTMC5
Huge Navigator TMC5 [HugePedia]
ClinGenTMC5
Clinical trials, drugs, therapy
MyCancerGenomeTMC5
Protein Interactions : CTDTMC5
Pharm GKB GenePA134923498
PharosQ6UXY8
Clinical trialTMC5
Miscellaneous
canSAR (ICR)TMC5
HarmonizomeTMC5
DataMed IndexTMC5
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:39 CEST 2021

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