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TMC6 (transmembrane channel like 6)

Identity

Alias (NCBI)EV1
EVER1
EVIN1
LAK-4P
TNRC6C-AS1
lnc
HGNC (Hugo) TMC6
HGNC Alias symbLAK-4P
EVIN1
HGNC Previous nameEVER1
 TNRC6C-AS1
HGNC Previous nameepidermodysplasia verruciformis 1
 TNRC6C antisense RNA 1
LocusID (NCBI) 11322
Atlas_Id 40507
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78112918 and ends at 78132427 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMC6 (17q25.3) / CRYM (16p12.2)TMC6 (17q25.3) / DNAH17 (17q25.3)TMC6 (17q25.3) / FAM104A (17q25.1)
TMC6 (17q25.3) / TK1 (17q25.3)TMC6 (17q25.3) / UACA (15q23)TMC6 17q25.3 / DNAH17 17q25.3
TMC6 17q25.3 / FAM104A 17q25.1TMC6 17q25.3 / TK1 17q25.3TMC6 17q25.3 / UACA 15q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Epidermodysplasia verruciformis


External links

 

Nomenclature
HGNC (Hugo)TMC6   18021
LRG (Locus Reference Genomic)LRG_118
Cards
Entrez_Gene (NCBI)TMC6    transmembrane channel like 6
AliasesEV1; EVER1; EVIN1; LAK-4P; 
TNRC6C-AS1; lnc
GeneCards (Weizmann)TMC6
Ensembl hg19 (Hinxton)ENSG00000141524 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141524 [Gene_View]  ENSG00000141524 [Sequence]  chr17:78112918-78132427 [Contig_View]  TMC6 [Vega]
ICGC DataPortalENSG00000141524
TCGA cBioPortalTMC6
AceView (NCBI)TMC6
Genatlas (Paris)TMC6
SOURCE (Princeton)TMC6
Genetics Home Reference (NIH)TMC6
Genomic and cartography
GoldenPath hg38 (UCSC)TMC6  -     chr17:78112918-78132427 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMC6  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathTMC6 - 17q25.3 [CytoView hg19]  TMC6 - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000141524
Genome Data Viewer NCBITMC6 [Mapview hg19]  
OMIM226400   605828   
Gene and transcription
Genbank (Entrez)AB002405 AK021738 AK074065 AK092916 AK094898
RefSeq transcript (Entrez)NM_001127198 NM_001321185 NM_001374593 NM_001374594 NM_001374596 NM_001375353 NM_001375354 NM_007267
Consensus coding sequences : CCDS (NCBI)TMC6
Gene ExpressionTMC6 [ NCBI-GEO ]   TMC6 [ EBI - ARRAY_EXPRESS ]   TMC6 [ SEEK ]   TMC6 [ MEM ]
Gene Expression Viewer (FireBrowse)TMC6 [ Firebrowse - Broad ]
GenevisibleExpression of TMC6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11322
GTEX Portal (Tissue expression)TMC6
Human Protein AtlasENSG00000141524-TMC6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z403
PhosPhoSitePlusQ7Z403
Domains : Interpro (EBI)TMC    TMC_dom   
Domain families : Pfam (Sanger)TMC (PF07810)   
Domain families : Pfam (NCBI)pfam07810   
Conserved Domain (NCBI)TMC6
SuperfamilyQ7Z403
AlphaFold pdb e-kbQ7Z403   
Human Protein Atlas [tissue]ENSG00000141524-TMC6 [tissue]
HPRD08386
Protein Interaction databases
DIP (DOE-UCLA)Q7Z403
IntAct (EBI)Q7Z403
BioGRIDTMC6
STRING (EMBL)TMC6
ZODIACTMC6
Ontologies - Pathways
QuickGOQ7Z403
Ontology : AmiGOprotein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  integral component of plasma membrane  biological_process  mechanosensitive ion channel activity  nuclear membrane  ion transmembrane transport  specific granule membrane  neutrophil degranulation  extracellular exosome  tertiary granule membrane  
Ontology : EGO-EBIprotein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  integral component of plasma membrane  biological_process  mechanosensitive ion channel activity  nuclear membrane  ion transmembrane transport  specific granule membrane  neutrophil degranulation  extracellular exosome  tertiary granule membrane  
NDEx NetworkTMC6
Atlas of Cancer Signalling NetworkTMC6
Wikipedia pathwaysTMC6
Orthology - Evolution
OrthoDB11322
GeneTree (enSembl)ENSG00000141524
Phylogenetic Trees/Animal Genes : TreeFamTMC6
Homologs : HomoloGeneTMC6
Homology/Alignments : Family Browser (UCSC)TMC6
Gene fusions - Rearrangements
Fusion : MitelmanTMC6/DNAH17 [17q25.3/17q25.3]  
Fusion : MitelmanTMC6/FAM104A [17q25.3/17q25.1]  
Fusion : MitelmanTMC6/TK1 [17q25.3/17q25.3]  
Fusion : MitelmanTMC6/UACA [17q25.3/15q23]  
Fusion : QuiverTMC6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMC6
dbVarTMC6
ClinVarTMC6
MonarchTMC6
1000_GenomesTMC6 
Exome Variant ServerTMC6
GNOMAD BrowserENSG00000141524
Varsome BrowserTMC6
ACMGTMC6 variants
VarityQ7Z403
Genomic Variants (DGV)TMC6 [DGVbeta]
DECIPHERTMC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMC6 
Mutations
ICGC Data PortalTMC6 
TCGA Data PortalTMC6 
Broad Tumor PortalTMC6
OASIS PortalTMC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMC6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMC6
Mutations and Diseases : HGMDTMC6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMC6
DgiDB (Drug Gene Interaction Database)TMC6
DoCM (Curated mutations)TMC6
CIViC (Clinical Interpretations of Variants in Cancer)TMC6
Cancer3DTMC6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM226400    605828   
Orphanet8531   
DisGeNETTMC6
MedgenTMC6
Genetic Testing Registry TMC6
NextProtQ7Z403 [Medical]
GENETestsTMC6
Target ValidationTMC6
Huge Navigator TMC6 [HugePedia]
ClinGenTMC6
Clinical trials, drugs, therapy
MyCancerGenomeTMC6
Protein Interactions : CTDTMC6
Pharm GKB GenePA134949466
PharosQ7Z403
Clinical trialTMC6
Miscellaneous
canSAR (ICR)TMC6
HarmonizomeTMC6
DataMed IndexTMC6
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:35:20 CEST 2021

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