Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TMC6 (transmembrane channel like 6)

Identity

Alias_namesEVER1
epidermodysplasia verruciformis 1
Alias_symbol (synonym)LAK-4P
EVIN1
Other aliasEV1
HGNC (Hugo) TMC6
LocusID (NCBI) 11322
Atlas_Id 40507
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78112918 and ends at 78128794 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TMC6 (17q25.3) / CRYM (16p12.2)TMC6 (17q25.3) / DNAH17 (17q25.3)TMC6 (17q25.3) / FAM104A (17q25.1)
TMC6 (17q25.3) / TK1 (17q25.3)TMC6 (17q25.3) / UACA (15q23)TMC6 17q25.3 / DNAH17 17q25.3
TMC6 17q25.3 / FAM104A 17q25.1TMC6 17q25.3 / TK1 17q25.3TMC6 17q25.3 / UACA 15q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Epidermodysplasia verruciformis


External links

Nomenclature
HGNC (Hugo)TMC6   18021
LRG (Locus Reference Genomic)LRG_118
Cards
Entrez_Gene (NCBI)TMC6  11322  transmembrane channel like 6
AliasesEV1; EVER1; EVIN1; LAK-4P
GeneCards (Weizmann)TMC6
Ensembl hg19 (Hinxton)ENSG00000141524 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141524 [Gene_View]  chr17:78112918-78128794 [Contig_View]  TMC6 [Vega]
ICGC DataPortalENSG00000141524
TCGA cBioPortalTMC6
AceView (NCBI)TMC6
Genatlas (Paris)TMC6
WikiGenes11322
SOURCE (Princeton)TMC6
Genetics Home Reference (NIH)TMC6
Genomic and cartography
GoldenPath hg38 (UCSC)TMC6  -     chr17:78112918-78128794 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMC6  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblTMC6 - 17q25.3 [CytoView hg19]  TMC6 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBITMC6 [Mapview hg19]  TMC6 [Mapview hg38]
OMIM226400   605828   
Gene and transcription
Genbank (Entrez)AB002405 AK021738 AK074065 AK096076 AK303165
RefSeq transcript (Entrez)NM_001127198 NM_001321185 NM_007267
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMC6
Cluster EST : UnigeneHs.632227 [ NCBI ]
CGAP (NCI)Hs.632227
Alternative Splicing GalleryENSG00000141524
Gene ExpressionTMC6 [ NCBI-GEO ]   TMC6 [ EBI - ARRAY_EXPRESS ]   TMC6 [ SEEK ]   TMC6 [ MEM ]
Gene Expression Viewer (FireBrowse)TMC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11322
GTEX Portal (Tissue expression)TMC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z403
Splice isoforms : SwissVarQ7Z403
PhosPhoSitePlusQ7Z403
Domains : Interpro (EBI)TMC   
Domain families : Pfam (Sanger)TMC (PF07810)   
Domain families : Pfam (NCBI)pfam07810   
Conserved Domain (NCBI)TMC6
DMDM Disease mutations11322
Blocks (Seattle)TMC6
SuperfamilyQ7Z403
Human Protein AtlasENSG00000141524
Peptide AtlasQ7Z403
HPRD08386
IPIIPI00179046   IPI00332386   IPI00647669   IPI00165591   IPI00910393   IPI00871466   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z403
IntAct (EBI)Q7Z403
FunCoupENSG00000141524
BioGRIDTMC6
STRING (EMBL)TMC6
ZODIACTMC6
Ontologies - Pathways
QuickGOQ7Z403
Ontology : AmiGOprotein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  ion transport  biological_process  integral component of membrane  nuclear membrane  specific granule membrane  neutrophil degranulation  extracellular exosome  tertiary granule membrane  
Ontology : EGO-EBIprotein binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  ion transport  biological_process  integral component of membrane  nuclear membrane  specific granule membrane  neutrophil degranulation  extracellular exosome  tertiary granule membrane  
NDEx NetworkTMC6
Atlas of Cancer Signalling NetworkTMC6
Wikipedia pathwaysTMC6
Orthology - Evolution
OrthoDB11322
GeneTree (enSembl)ENSG00000141524
Phylogenetic Trees/Animal Genes : TreeFamTMC6
HOVERGENQ7Z403
HOGENOMQ7Z403
Homologs : HomoloGeneTMC6
Homology/Alignments : Family Browser (UCSC)TMC6
Gene fusions - Rearrangements
Fusion : MitelmanTMC6/DNAH17 [17q25.3/17q25.3]  
Fusion : MitelmanTMC6/FAM104A [17q25.3/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanTMC6/TK1 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanTMC6/UACA [17q25.3/15q23]  [t(15;17)(q23;q25)]  
Fusion: TCGATMC6 17q25.3 DNAH17 17q25.3 LUAD
Fusion: TCGATMC6 17q25.3 FAM104A 17q25.1 BRCA
Fusion: TCGATMC6 17q25.3 TK1 17q25.3 OV
Fusion: TCGATMC6 17q25.3 UACA 15q23 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMC6
dbVarTMC6
ClinVarTMC6
1000_GenomesTMC6 
Exome Variant ServerTMC6
ExAC (Exome Aggregation Consortium)TMC6 (select the gene name)
Genetic variants : HAPMAP11322
Genomic Variants (DGV)TMC6 [DGVbeta]
DECIPHERTMC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMC6 
Mutations
ICGC Data PortalTMC6 
TCGA Data PortalTMC6 
Broad Tumor PortalTMC6
OASIS PortalTMC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch TMC6
DgiDB (Drug Gene Interaction Database)TMC6
DoCM (Curated mutations)TMC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMC6 (select a term)
intoGenTMC6
Cancer3DTMC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM226400    605828   
Orphanet8531   
MedgenTMC6
Genetic Testing Registry TMC6
NextProtQ7Z403 [Medical]
TSGene11322
GENETestsTMC6
Target ValidationTMC6
Huge Navigator TMC6 [HugePedia]
snp3D : Map Gene to Disease11322
BioCentury BCIQTMC6
ClinGenTMC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11322
Chemical/Pharm GKB GenePA134949466
Clinical trialTMC6
Miscellaneous
canSAR (ICR)TMC6 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMC6
EVEXTMC6
GoPubMedTMC6
iHOPTMC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:17:02 CEST 2017

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