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TMCC2 (transmembrane and coiled-coil domain family 2)

Identity

Alias_namestransmembrane and coiled-coil domains 2
Alias_symbol (synonym)HUCEP11
FLJ38497
Other alias
HGNC (Hugo) TMCC2
LocusID (NCBI) 9911
Atlas_Id 74749
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205228931 and ends at 205273343 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMCC2 (1q32.1) / HMCN1 (1q25.3)TMCC2 (1q32.1) / TMCC2 (1q32.1)WDR74 (11q12.3) / TMCC2 (1q32.1)
ZC3H11A (1q32.1) / TMCC2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(q25;q32) TMCC2/HMCN1
t(1;1)(q32;q32) ZC3H11A/TMCC2

External links

Nomenclature
HGNC (Hugo)TMCC2   24239
Cards
Entrez_Gene (NCBI)TMCC2  9911  transmembrane and coiled-coil domain family 2
AliasesHUCEP11
GeneCards (Weizmann)TMCC2
Ensembl hg19 (Hinxton)ENSG00000133069 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133069 [Gene_View]  ENSG00000133069 [Sequence]  chr1:205228931-205273343 [Contig_View]  TMCC2 [Vega]
ICGC DataPortalENSG00000133069
TCGA cBioPortalTMCC2
AceView (NCBI)TMCC2
Genatlas (Paris)TMCC2
WikiGenes9911
SOURCE (Princeton)TMCC2
Genetics Home Reference (NIH)TMCC2
Genomic and cartography
GoldenPath hg38 (UCSC)TMCC2  -     chr1:205228931-205273343 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMCC2  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblTMCC2 - 1q32.1 [CytoView hg19]  TMCC2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBITMCC2 [Mapview hg19]  TMCC2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB001596 AB007950 AK094913 AK095816 AK131419
RefSeq transcript (Entrez)NM_001242925 NM_001297611 NM_001297613 NM_001331034 NM_014858
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMCC2
Cluster EST : UnigeneHs.6360 [ NCBI ]
CGAP (NCI)Hs.6360
Alternative Splicing GalleryENSG00000133069
Gene ExpressionTMCC2 [ NCBI-GEO ]   TMCC2 [ EBI - ARRAY_EXPRESS ]   TMCC2 [ SEEK ]   TMCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMCC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9911
GTEX Portal (Tissue expression)TMCC2
Human Protein AtlasENSG00000133069-TMCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75069   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75069  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75069
Splice isoforms : SwissVarO75069
PhosPhoSitePlusO75069
Domains : Interpro (EBI)TEX28/TMCC   
Domain families : Pfam (Sanger)Tmemb_cc2 (PF10267)   
Domain families : Pfam (NCBI)pfam10267   
Conserved Domain (NCBI)TMCC2
DMDM Disease mutations9911
Blocks (Seattle)TMCC2
SuperfamilyO75069
Human Protein Atlas [tissue]ENSG00000133069-TMCC2 [tissue]
Peptide AtlasO75069
HPRD11040
IPIIPI00432736   
Protein Interaction databases
DIP (DOE-UCLA)O75069
IntAct (EBI)O75069
FunCoupENSG00000133069
BioGRIDTMCC2
STRING (EMBL)TMCC2
ZODIACTMCC2
Ontologies - Pathways
QuickGOO75069
Ontology : AmiGOprotein binding  endoplasmic reticulum  integral component of membrane  amyloid precursor protein metabolic process  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  integral component of membrane  amyloid precursor protein metabolic process  
NDEx NetworkTMCC2
Atlas of Cancer Signalling NetworkTMCC2
Wikipedia pathwaysTMCC2
Orthology - Evolution
OrthoDB9911
GeneTree (enSembl)ENSG00000133069
Phylogenetic Trees/Animal Genes : TreeFamTMCC2
HOVERGENO75069
HOGENOMO75069
Homologs : HomoloGeneTMCC2
Homology/Alignments : Family Browser (UCSC)TMCC2
Gene fusions - Rearrangements
Fusion : QuiverTMCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMCC2
dbVarTMCC2
ClinVarTMCC2
1000_GenomesTMCC2 
Exome Variant ServerTMCC2
ExAC (Exome Aggregation Consortium)ENSG00000133069
GNOMAD BrowserENSG00000133069
Varsome BrowserTMCC2
Genetic variants : HAPMAP9911
Genomic Variants (DGV)TMCC2 [DGVbeta]
DECIPHERTMCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMCC2 
Mutations
ICGC Data PortalTMCC2 
TCGA Data PortalTMCC2 
Broad Tumor PortalTMCC2
OASIS PortalTMCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMCC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMCC2
DgiDB (Drug Gene Interaction Database)TMCC2
DoCM (Curated mutations)TMCC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMCC2 (select a term)
intoGenTMCC2
Cancer3DTMCC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMCC2
MedgenTMCC2
Genetic Testing Registry TMCC2
NextProtO75069 [Medical]
TSGene9911
GENETestsTMCC2
Target ValidationTMCC2
Huge Navigator TMCC2 [HugePedia]
snp3D : Map Gene to Disease9911
BioCentury BCIQTMCC2
ClinGenTMCC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9911
Chemical/Pharm GKB GenePA134963344
Clinical trialTMCC2
Miscellaneous
canSAR (ICR)TMCC2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMCC2
EVEXTMCC2
GoPubMedTMCC2
iHOPTMCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:35:02 CEST 2018
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