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TMCC2 (transmembrane and coiled-coil domain family 2)

Identity

Alias (NCBI)HUCEP11
HGNC (Hugo) TMCC2
HGNC Alias symbHUCEP11
FLJ38497
HGNC Previous nametransmembrane and coiled-coil domains 2
LocusID (NCBI) 9911
Atlas_Id 74749
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205227910 and ends at 205273343 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMCC2 (1q32.1) / HMCN1 (1q25.3)TMCC2 (1q32.1) / TMCC2 (1q32.1)WDR74 (11q12.3) / TMCC2 (1q32.1)
ZC3H11A (1q32.1) / TMCC2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(q25;q32) TMCC2/HMCN1
ZC3H11A/TMCC2 (1q32)

External links

Nomenclature
HGNC (Hugo)TMCC2   24239
Cards
Entrez_Gene (NCBI)TMCC2    transmembrane and coiled-coil domain family 2
AliasesHUCEP11
GeneCards (Weizmann)TMCC2
Ensembl hg19 (Hinxton)ENSG00000133069 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133069 [Gene_View]  ENSG00000133069 [Sequence]  chr1:205227910-205273343 [Contig_View]  TMCC2 [Vega]
ICGC DataPortalENSG00000133069
TCGA cBioPortalTMCC2
AceView (NCBI)TMCC2
Genatlas (Paris)TMCC2
SOURCE (Princeton)TMCC2
Genetics Home Reference (NIH)TMCC2
Genomic and cartography
GoldenPath hg38 (UCSC)TMCC2  -     chr1:205227910-205273343 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMCC2  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathTMCC2 - 1q32.1 [CytoView hg19]  TMCC2 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000133069
genome Data Viewer NCBITMCC2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB001596 AB007950 AK094913 AK095816 AK131419
RefSeq transcript (Entrez)NM_001242925 NM_001297611 NM_001297613 NM_001331034 NM_001375651 NM_001375652 NM_014858
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMCC2
Alternative Splicing GalleryENSG00000133069
Gene ExpressionTMCC2 [ NCBI-GEO ]   TMCC2 [ EBI - ARRAY_EXPRESS ]   TMCC2 [ SEEK ]   TMCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMCC2 [ Firebrowse - Broad ]
GenevisibleExpression of TMCC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9911
GTEX Portal (Tissue expression)TMCC2
Human Protein AtlasENSG00000133069-TMCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75069   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75069  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75069
Splice isoforms : SwissVarO75069
PhosPhoSitePlusO75069
Domains : Interpro (EBI)TEX28/TMCC   
Domain families : Pfam (Sanger)Tmemb_cc2 (PF10267)   
Domain families : Pfam (NCBI)pfam10267   
Conserved Domain (NCBI)TMCC2
Blocks (Seattle)TMCC2
SuperfamilyO75069
Human Protein Atlas [tissue]ENSG00000133069-TMCC2 [tissue]
Peptide AtlasO75069
HPRD11040
IPIIPI00432736   
Protein Interaction databases
DIP (DOE-UCLA)O75069
IntAct (EBI)O75069
BioGRIDTMCC2
STRING (EMBL)TMCC2
ZODIACTMCC2
Ontologies - Pathways
QuickGOO75069
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  amyloid precursor protein metabolic process  amyloid precursor protein metabolic process  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  amyloid precursor protein metabolic process  amyloid precursor protein metabolic process  
NDEx NetworkTMCC2
Atlas of Cancer Signalling NetworkTMCC2
Wikipedia pathwaysTMCC2
Orthology - Evolution
OrthoDB9911
GeneTree (enSembl)ENSG00000133069
Phylogenetic Trees/Animal Genes : TreeFamTMCC2
HOGENOMO75069
Homologs : HomoloGeneTMCC2
Homology/Alignments : Family Browser (UCSC)TMCC2
Gene fusions - Rearrangements
Fusion : QuiverTMCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMCC2 [hg38]
dbVarTMCC2
ClinVarTMCC2
MonarchTMCC2
1000_GenomesTMCC2 
Exome Variant ServerTMCC2
GNOMAD BrowserENSG00000133069
Varsome BrowserTMCC2
Genomic Variants (DGV)TMCC2 [DGVbeta]
DECIPHERTMCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMCC2 
Mutations
ICGC Data PortalTMCC2 
TCGA Data PortalTMCC2 
Broad Tumor PortalTMCC2
OASIS PortalTMCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMCC2
Mutations and Diseases : HGMDTMCC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMCC2
DgiDB (Drug Gene Interaction Database)TMCC2
DoCM (Curated mutations)TMCC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMCC2 (select a term)
intoGenTMCC2
Cancer3DTMCC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMCC2
MedgenTMCC2
Genetic Testing Registry TMCC2
NextProtO75069 [Medical]
GENETestsTMCC2
Target ValidationTMCC2
Huge Navigator TMCC2 [HugePedia]
ClinGenTMCC2
Clinical trials, drugs, therapy
MyCancerGenomeTMCC2
Protein Interactions : CTD
Pharm GKB GenePA134963344
Clinical trialTMCC2
Miscellaneous
canSAR (ICR)TMCC2 (select the gene name)
HarmonizomeTMCC2
DataMed IndexTMCC2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMCC2
EVEXTMCC2
GoPubMedTMCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Dec 5 17:31:52 CET 2020
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