TMED10 (transmembrane p24 trafficking protein 10)

2016-10-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
P24(DELTA),S31I125,S31III125,TMP21,Tmp-21-I,p23,p24d1
FUSION GENES

Other Information

Locus ID:

NCBI: 10972
MIM: 605406
HGNC: 16998
Ensembl: ENSG00000170348

Variants:

dbSNP: 10972
ClinVar: 10972
TCGA: ENSG00000170348
COSMIC: TMED10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170348ENST00000303575P49755
ENSG00000170348ENST00000303575A0A024R6I3
ENSG00000170348ENST00000555873G3V2K7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166419992006TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.123
193431782009Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.112
214545412011p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.20
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
190463802008TMP21 degradation is mediated by the ubiquitin-proteasome pathway.15
201642562010p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains.15
212193312011Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.12
197100222009TMP21 transmembrane domain regulates gamma-secretase cleavage.10
222043042011Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice.10
186528962008Localization and regional distribution of p23/TMP21 in the brain.9

Citation

Dessen P

TMED10 (transmembrane p24 trafficking protein 10)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56626/tmed10