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TMED10 (transmembrane p24 trafficking protein 10)

Identity

Alias (NCBI)P24(DELTA)
S31I125
S31III125
TMP21
Tmp-21-I
p23
p24d1
HGNC (Hugo) TMED10
HGNC Alias symbTMP21
P24(DELTA)
p24d1
p24delta1
p23
HGNC Previous nametransmembrane emp24-like trafficking protein 10 (yeast)
LocusID (NCBI) 10972
Atlas_Id 56626
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 75131469 and ends at 75176612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DISP2 (15q15.1) / TMED10 (14q24.3)IL6 (7p15.3) / TMED10 (14q24.3)LOC100507412 (-) / TMED10 (14q24.3)
TMED10 (14q24.3) / IL6 (7p15.3)TMED10 (14q24.3) / MALAT1 (11q13.1)TMED10 (14q24.3) / PSMD11 (17q11.2)
TMED10 (14q24.3) / THSD4 (15q23)TMED10 (14q24.3) / TTLL5 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMED10   16998
Cards
Entrez_Gene (NCBI)TMED10    transmembrane p24 trafficking protein 10
AliasesP24(DELTA); S31I125; S31III125; TMP21; 
Tmp-21-I; p23; p24d1
GeneCards (Weizmann)TMED10
Ensembl hg19 (Hinxton)ENSG00000170348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170348 [Gene_View]  ENSG00000170348 [Sequence]  chr14:75131469-75176612 [Contig_View]  TMED10 [Vega]
ICGC DataPortalENSG00000170348
TCGA cBioPortalTMED10
AceView (NCBI)TMED10
Genatlas (Paris)TMED10
SOURCE (Princeton)TMED10
Genetics Home Reference (NIH)TMED10
Genomic and cartography
GoldenPath hg38 (UCSC)TMED10  -     chr14:75131469-75176612 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMED10  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathTMED10 - 14q24.3 [CytoView hg19]  TMED10 - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000170348
Genome Data Viewer NCBITMED10 [Mapview hg19]  
OMIM605406   
Gene and transcription
Genbank (Entrez)AJ004913 AK023615 AK056156 AK222972 AK296800
RefSeq transcript (Entrez)NM_006827
Consensus coding sequences : CCDS (NCBI)TMED10
Gene ExpressionTMED10 [ NCBI-GEO ]   TMED10 [ EBI - ARRAY_EXPRESS ]   TMED10 [ SEEK ]   TMED10 [ MEM ]
Gene Expression Viewer (FireBrowse)TMED10 [ Firebrowse - Broad ]
GenevisibleExpression of TMED10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10972
GTEX Portal (Tissue expression)TMED10
Human Protein AtlasENSG00000170348-TMED10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49755   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49755  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49755
PhosPhoSitePlusP49755
Domaine pattern : Prosite (Expaxy)GOLD (PS50866)   
Domains : Interpro (EBI)Emp24-like    GOLD_dom   
Domain families : Pfam (Sanger)EMP24_GP25L (PF01105)   
Domain families : Pfam (NCBI)pfam01105   
Domain families : Smart (EMBL)EMP24_GP25L (SM01190)  
Conserved Domain (NCBI)TMED10
SuperfamilyP49755
AlphaFold pdb e-kbP49755   
Human Protein Atlas [tissue]ENSG00000170348-TMED10 [tissue]
HPRD12013
Protein Interaction databases
DIP (DOE-UCLA)P49755
IntAct (EBI)P49755
BioGRIDTMED10
STRING (EMBL)TMED10
ZODIACTMED10
Ontologies - Pathways
QuickGOP49755
Ontology : AmiGOGolgi membrane  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  plasma membrane  intracellular protein transport  intracellular protein transport  endoplasmic reticulum to Golgi vesicle-mediated transport  endoplasmic reticulum to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  Golgi organization  protein transmembrane transporter activity  ER to Golgi transport vesicle membrane  integral component of membrane  syntaxin binding  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle  trans-Golgi network transport vesicle  secretory granule membrane  positive regulation of interleukin-1 production  endoplasmic reticulum-Golgi intermediate compartment membrane  vesicle cargo loading  COPI-coated vesicle budding  melanosome  zymogen granule membrane  response to alkaloid  protein-containing complex binding  regulated exocytosis  vesicle targeting, to, from or within Golgi  COPI coating of Golgi vesicle  COPII vesicle coating  positive regulation of protein secretion  gamma-secretase complex  protein transmembrane transport  protein localization to ERGIC  cytosol to ERGIC protein transport  regulation of amyloid-beta formation  negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  
Ontology : EGO-EBIGolgi membrane  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  plasma membrane  intracellular protein transport  intracellular protein transport  endoplasmic reticulum to Golgi vesicle-mediated transport  endoplasmic reticulum to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  Golgi organization  protein transmembrane transporter activity  ER to Golgi transport vesicle membrane  integral component of membrane  syntaxin binding  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle  trans-Golgi network transport vesicle  secretory granule membrane  positive regulation of interleukin-1 production  endoplasmic reticulum-Golgi intermediate compartment membrane  vesicle cargo loading  COPI-coated vesicle budding  melanosome  zymogen granule membrane  response to alkaloid  protein-containing complex binding  regulated exocytosis  vesicle targeting, to, from or within Golgi  COPI coating of Golgi vesicle  COPII vesicle coating  positive regulation of protein secretion  gamma-secretase complex  protein transmembrane transport  protein localization to ERGIC  cytosol to ERGIC protein transport  regulation of amyloid-beta formation  negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  
NDEx NetworkTMED10
Atlas of Cancer Signalling NetworkTMED10
Wikipedia pathwaysTMED10
Orthology - Evolution
OrthoDB10972
GeneTree (enSembl)ENSG00000170348
Phylogenetic Trees/Animal Genes : TreeFamTMED10
Homologs : HomoloGeneTMED10
Homology/Alignments : Family Browser (UCSC)TMED10
Gene fusions - Rearrangements
Fusion : QuiverTMED10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMED10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMED10
dbVarTMED10
ClinVarTMED10
MonarchTMED10
1000_GenomesTMED10 
Exome Variant ServerTMED10
GNOMAD BrowserENSG00000170348
Varsome BrowserTMED10
ACMGTMED10 variants
VarityP49755
Genomic Variants (DGV)TMED10 [DGVbeta]
DECIPHERTMED10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMED10 
Mutations
ICGC Data PortalTMED10 
TCGA Data PortalTMED10 
Broad Tumor PortalTMED10
OASIS PortalTMED10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMED10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMED10
Mutations and Diseases : HGMDTMED10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMED10
DgiDB (Drug Gene Interaction Database)TMED10
DoCM (Curated mutations)TMED10
CIViC (Clinical Interpretations of Variants in Cancer)TMED10
Cancer3DTMED10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605406   
Orphanet
DisGeNETTMED10
MedgenTMED10
Genetic Testing Registry TMED10
NextProtP49755 [Medical]
GENETestsTMED10
Target ValidationTMED10
Huge Navigator TMED10 [HugePedia]
ClinGenTMED10
Clinical trials, drugs, therapy
MyCancerGenomeTMED10
Protein Interactions : CTDTMED10
Pharm GKB GenePA128394579
PharosP49755
Clinical trialTMED10
Miscellaneous
canSAR (ICR)TMED10
HarmonizomeTMED10
DataMed IndexTMED10
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMED10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:20 CEST 2021

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