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TMED2 (transmembrane p24 trafficking protein 2)

Identity

Alias (NCBI)P24A
RNP24
p24
p24b1
p24beta1
HGNC (Hugo) TMED2
HGNC Alias symbRNP24
P24A
p24beta1
p24b1
HGNC Previous nametransmembrane emp24 domain trafficking protein 2
LocusID (NCBI) 10959
Atlas_Id 52521
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 123584552 and ends at 123598582 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MDK (11p11.2) / TMED2 (12q24.31)TMED2 (12q24.31) / PARM1 (4q13.3)TMED2 (12q24.31) / PPIA (7p13)
TMED2 (12q24.31) / TMED2 (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TMED2   16996
Cards
Entrez_Gene (NCBI)TMED2    transmembrane p24 trafficking protein 2
AliasesP24A; RNP24; p24; p24b1; 
p24beta1
GeneCards (Weizmann)TMED2
Ensembl hg19 (Hinxton)ENSG00000086598 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086598 [Gene_View]  ENSG00000086598 [Sequence]  chr12:123584552-123598582 [Contig_View]  TMED2 [Vega]
ICGC DataPortalENSG00000086598
TCGA cBioPortalTMED2
AceView (NCBI)TMED2
Genatlas (Paris)TMED2
SOURCE (Princeton)TMED2
Genetics Home Reference (NIH)TMED2
Genomic and cartography
GoldenPath hg38 (UCSC)TMED2  -     chr12:123584552-123598582 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMED2  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathTMED2 - 12q24.31 [CytoView hg19]  TMED2 - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000086598
genome Data Viewer NCBITMED2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI954929 AK024976 AK298167 AK303189 AK312975
RefSeq transcript (Entrez)NM_001321445 NM_006815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMED2
Alternative Splicing GalleryENSG00000086598
Gene ExpressionTMED2 [ NCBI-GEO ]   TMED2 [ EBI - ARRAY_EXPRESS ]   TMED2 [ SEEK ]   TMED2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMED2 [ Firebrowse - Broad ]
GenevisibleExpression of TMED2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10959
GTEX Portal (Tissue expression)TMED2
Human Protein AtlasENSG00000086598-TMED2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15363   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15363  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15363
Splice isoforms : SwissVarQ15363
PhosPhoSitePlusQ15363
Domaine pattern : Prosite (Expaxy)GOLD (PS50866)   
Domains : Interpro (EBI)GOLD_dom    GOLD_dom_sf    TMP21-related   
Domain families : Pfam (Sanger)EMP24_GP25L (PF01105)   
Domain families : Pfam (NCBI)pfam01105   
Domain families : Smart (EMBL)EMP24_GP25L (SM01190)  
Conserved Domain (NCBI)TMED2
Blocks (Seattle)TMED2
PDB (RSDB)5AZW   
PDB Europe5AZW   
PDB (PDBSum)5AZW   
PDB (IMB)5AZW   
Structural Biology KnowledgeBase5AZW   
SCOP (Structural Classification of Proteins)5AZW   
CATH (Classification of proteins structures)5AZW   
SuperfamilyQ15363
Human Protein Atlas [tissue]ENSG00000086598-TMED2 [tissue]
Peptide AtlasQ15363
HPRD17984
IPIIPI00016608   IPI00797864   IPI00909375   IPI01012491   
Protein Interaction databases
DIP (DOE-UCLA)Q15363
IntAct (EBI)Q15363
BioGRIDTMED2
STRING (EMBL)TMED2
ZODIACTMED2
Ontologies - Pathways
QuickGOQ15363
Ontology : AmiGOGolgi membrane  neural tube closure  maternal placenta development  heart looping  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  intracellular protein transport  intracellular protein transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  Golgi organization  Golgi organization  positive regulation of gene expression  ER to Golgi transport vesicle membrane  integral component of membrane  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle membrane  somite rostral/caudal axis specification  Golgi cisterna membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  negative regulation of GTPase activity  multicellular organism growth  cargo loading into vesicle  post-anal tail morphogenesis  zymogen granule membrane  intracellular membrane-bounded organelle  COPI coating of Golgi vesicle  COPII vesicle coating  labyrinthine layer blood vessel development  protein localization to plasma membrane  
Ontology : EGO-EBIGolgi membrane  neural tube closure  maternal placenta development  heart looping  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  intracellular protein transport  intracellular protein transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  Golgi organization  Golgi organization  positive regulation of gene expression  ER to Golgi transport vesicle membrane  integral component of membrane  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle membrane  somite rostral/caudal axis specification  Golgi cisterna membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  negative regulation of GTPase activity  multicellular organism growth  cargo loading into vesicle  post-anal tail morphogenesis  zymogen granule membrane  intracellular membrane-bounded organelle  COPI coating of Golgi vesicle  COPII vesicle coating  labyrinthine layer blood vessel development  protein localization to plasma membrane  
NDEx NetworkTMED2
Atlas of Cancer Signalling NetworkTMED2
Wikipedia pathwaysTMED2
Orthology - Evolution
OrthoDB10959
GeneTree (enSembl)ENSG00000086598
Phylogenetic Trees/Animal Genes : TreeFamTMED2
HOGENOMQ15363
Homologs : HomoloGeneTMED2
Homology/Alignments : Family Browser (UCSC)TMED2
Gene fusions - Rearrangements
Fusion : QuiverTMED2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMED2 [hg38]
dbVarTMED2
ClinVarTMED2
MonarchTMED2
1000_GenomesTMED2 
Exome Variant ServerTMED2
GNOMAD BrowserENSG00000086598
Varsome BrowserTMED2
Genomic Variants (DGV)TMED2 [DGVbeta]
DECIPHERTMED2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMED2 
Mutations
ICGC Data PortalTMED2 
TCGA Data PortalTMED2 
Broad Tumor PortalTMED2
OASIS PortalTMED2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMED2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMED2
Mutations and Diseases : HGMDTMED2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMED2
DgiDB (Drug Gene Interaction Database)TMED2
DoCM (Curated mutations)TMED2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMED2 (select a term)
intoGenTMED2
Cancer3DTMED2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMED2
MedgenTMED2
Genetic Testing Registry TMED2
NextProtQ15363 [Medical]
GENETestsTMED2
Target ValidationTMED2
Huge Navigator TMED2 [HugePedia]
ClinGenTMED2
Clinical trials, drugs, therapy
MyCancerGenomeTMED2
Protein Interactions : CTD
Pharm GKB GenePA142670796
PharosQ15363
Clinical trialTMED2
Miscellaneous
canSAR (ICR)TMED2 (select the gene name)
HarmonizomeTMED2
DataMed IndexTMED2
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMED2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:41:24 CET 2021
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