TMED2 (transmembrane p24 trafficking protein 2)

2011-07-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
P24A,RNP24,p24,p24b1,p24beta1
FUSION GENES

Other Information

Locus ID:

NCBI: 10959
HGNC: 16996
Ensembl: ENSG00000086598

Variants:

dbSNP: 10959
ClinVar: 10959
TCGA: ENSG00000086598
COSMIC: TMED2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086598ENST00000262225Q15363
ENSG00000086598ENST00000262225Q6FHT8
ENSG00000086598ENST00000438031E7EQ72
ENSG00000086598ENST00000509052F5GX39

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176934102007p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.24
212193312011Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.12
2756904620163D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.7
203619382010The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway.6
222122502012TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.6
305409412018TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.4

Citation

Dessen P

TMED2 (transmembrane p24 trafficking protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52521/tmed2