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TMED4 (transmembrane p24 trafficking protein 4)

Identity

Alias_namestransmembrane emp24 protein transport domain containing 4
Alias_symbol (synonym)HNLF
p24alpha3
p24a3
Other aliasERS25
GMP25iso
HGNC (Hugo) TMED4
LocusID (NCBI) 222068
Atlas_Id 74762
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44579891 and ends at 44582295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HTT (4p16.3) / TMED4 (7p13)TMED4 (7p13) / DDX56 (7p13)TMED4 (7p13) / ENG (9q34.11)
TMEM241 (18q11.2) / TMED4 (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMED4   22301
Cards
Entrez_Gene (NCBI)TMED4  222068  transmembrane p24 trafficking protein 4
AliasesERS25; GMP25iso; HNLF; p24a3; 
p24alpha3
GeneCards (Weizmann)TMED4
Ensembl hg19 (Hinxton)ENSG00000158604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158604 [Gene_View]  chr7:44579891-44582295 [Contig_View]  TMED4 [Vega]
ICGC DataPortalENSG00000158604
TCGA cBioPortalTMED4
AceView (NCBI)TMED4
Genatlas (Paris)TMED4
WikiGenes222068
SOURCE (Princeton)TMED4
Genetics Home Reference (NIH)TMED4
Genomic and cartography
GoldenPath hg38 (UCSC)TMED4  -     chr7:44579891-44582295 -  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMED4  -     7p13   [Description]    (hg19-Feb_2009)
EnsemblTMED4 - 7p13 [CytoView hg19]  TMED4 - 7p13 [CytoView hg38]
Mapping of homologs : NCBITMED4 [Mapview hg19]  TMED4 [Mapview hg38]
OMIM612038   
Gene and transcription
Genbank (Entrez)AB097009 AK074557 AK290125 AK294122 AL602839
RefSeq transcript (Entrez)NM_001303058 NM_001303059 NM_001303060 NM_001303061 NM_001303062 NM_182547
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMED4
Cluster EST : UnigeneHs.598832 [ NCBI ]
CGAP (NCI)Hs.598832
Alternative Splicing GalleryENSG00000158604
Gene ExpressionTMED4 [ NCBI-GEO ]   TMED4 [ EBI - ARRAY_EXPRESS ]   TMED4 [ SEEK ]   TMED4 [ MEM ]
Gene Expression Viewer (FireBrowse)TMED4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222068
GTEX Portal (Tissue expression)TMED4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7H5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z7H5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7H5
Splice isoforms : SwissVarQ7Z7H5
PhosPhoSitePlusQ7Z7H5
Domaine pattern : Prosite (Expaxy)GOLD (PS50866)   
Domains : Interpro (EBI)GOLD_dom    TMP21-related   
Domain families : Pfam (Sanger)EMP24_GP25L (PF01105)   
Domain families : Pfam (NCBI)pfam01105   
Domain families : Smart (EMBL)EMP24_GP25L (SM01190)  
Conserved Domain (NCBI)TMED4
DMDM Disease mutations222068
Blocks (Seattle)TMED4
SuperfamilyQ7Z7H5
Human Protein AtlasENSG00000158604
Peptide AtlasQ7Z7H5
HPRD13666
IPIIPI00296259   IPI00914891   IPI00914908   IPI00953634   IPI00925777   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7H5
IntAct (EBI)Q7Z7H5
FunCoupENSG00000158604
BioGRIDTMED4
STRING (EMBL)TMED4
ZODIACTMED4
Ontologies - Pathways
QuickGOQ7Z7H5
Ontology : AmiGOsignal transducer activity  endoplasmic reticulum membrane  signal transduction  protein transport  integral component of membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  extracellular exosome  
Ontology : EGO-EBIsignal transducer activity  endoplasmic reticulum membrane  signal transduction  protein transport  integral component of membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  extracellular exosome  
NDEx NetworkTMED4
Atlas of Cancer Signalling NetworkTMED4
Wikipedia pathwaysTMED4
Orthology - Evolution
OrthoDB222068
GeneTree (enSembl)ENSG00000158604
Phylogenetic Trees/Animal Genes : TreeFamTMED4
HOVERGENQ7Z7H5
HOGENOMQ7Z7H5
Homologs : HomoloGeneTMED4
Homology/Alignments : Family Browser (UCSC)TMED4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMED4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMED4
dbVarTMED4
ClinVarTMED4
1000_GenomesTMED4 
Exome Variant ServerTMED4
ExAC (Exome Aggregation Consortium)TMED4 (select the gene name)
Genetic variants : HAPMAP222068
Genomic Variants (DGV)TMED4 [DGVbeta]
DECIPHERTMED4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMED4 
Mutations
ICGC Data PortalTMED4 
TCGA Data PortalTMED4 
Broad Tumor PortalTMED4
OASIS PortalTMED4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMED4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMED4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMED4
DgiDB (Drug Gene Interaction Database)TMED4
DoCM (Curated mutations)TMED4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMED4 (select a term)
intoGenTMED4
Cancer3DTMED4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612038   
Orphanet
MedgenTMED4
Genetic Testing Registry TMED4
NextProtQ7Z7H5 [Medical]
TSGene222068
GENETestsTMED4
Target ValidationTMED4
Huge Navigator TMED4 [HugePedia]
snp3D : Map Gene to Disease222068
BioCentury BCIQTMED4
ClinGenTMED4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD222068
Chemical/Pharm GKB GenePA134983854
Clinical trialTMED4
Miscellaneous
canSAR (ICR)TMED4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMED4
EVEXTMED4
GoPubMedTMED4
iHOPTMED4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:41:35 CEST 2017

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