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TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2)

Identity

Alias_namestransmembrane protein with EGF-like and two follistatin-like domains 2
Alias_symbol (synonym)TENB2
HPP1
TR
TPEF
CT120.2
Other aliasTR-2
HGNC (Hugo) TMEFF2
LocusID (NCBI) 23671
Atlas_Id 42587
Location 2q32.3  [Link to chromosome band 2q32]
Location_base_pair Starts at 192813772 and ends at 193059659 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SDPR (2q32.3) / TMEFF2 (2q32.3)TMEFF2 (2q32.3) / BBS9 (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEFF2   11867
Cards
Entrez_Gene (NCBI)TMEFF2  23671  transmembrane protein with EGF like and two follistatin like domains 2
AliasesCT120.2; HPP1; TENB2; TPEF; 
TR; TR-2
GeneCards (Weizmann)TMEFF2
Ensembl hg19 (Hinxton)ENSG00000144339 [Gene_View]  chr2:192813772-193059659 [Contig_View]  TMEFF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000144339 [Gene_View]  chr2:192813772-193059659 [Contig_View]  TMEFF2 [Vega]
ICGC DataPortalENSG00000144339
TCGA cBioPortalTMEFF2
AceView (NCBI)TMEFF2
Genatlas (Paris)TMEFF2
WikiGenes23671
SOURCE (Princeton)TMEFF2
Genetics Home Reference (NIH)TMEFF2
Genomic and cartography
GoldenPath hg19 (UCSC)TMEFF2  -     chr2:192813772-193059659 -  2q32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMEFF2  -     2q32.3   [Description]    (hg38-Dec_2013)
EnsemblTMEFF2 - 2q32.3 [CytoView hg19]  TMEFF2 - 2q32.3 [CytoView hg38]
Mapping of homologs : NCBITMEFF2 [Mapview hg19]  TMEFF2 [Mapview hg38]
OMIM605734   
Gene and transcription
Genbank (Entrez)AB004064 AB017269 AF179274 AF242222 AK054646
RefSeq transcript (Entrez)NM_001305134 NM_001305145 NM_016192
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)TMEFF2
Cluster EST : UnigeneHs.144513 [ NCBI ]
CGAP (NCI)Hs.144513
Alternative Splicing GalleryENSG00000144339
Gene ExpressionTMEFF2 [ NCBI-GEO ]   TMEFF2 [ EBI - ARRAY_EXPRESS ]   TMEFF2 [ SEEK ]   TMEFF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEFF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23671
GTEX Portal (Tissue expression)TMEFF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIK5
Splice isoforms : SwissVarQ9UIK5
PhosPhoSitePlusQ9UIK5
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Kazal_dom   
Domain families : Pfam (Sanger)hEGF (PF12661)    Kazal_2 (PF07648)   
Domain families : Pfam (NCBI)pfam12661    pfam07648   
Domain families : Smart (EMBL)EGF (SM00181)  KAZAL (SM00280)  
Conserved Domain (NCBI)TMEFF2
DMDM Disease mutations23671
Blocks (Seattle)TMEFF2
PDB (SRS)2FMW   
PDB (PDBSum)2FMW   
PDB (IMB)2FMW   
PDB (RSDB)2FMW   
Structural Biology KnowledgeBase2FMW   
SCOP (Structural Classification of Proteins)2FMW   
CATH (Classification of proteins structures)2FMW   
SuperfamilyQ9UIK5
Human Protein AtlasENSG00000144339
Peptide AtlasQ9UIK5
HPRD05760
IPIIPI00296286   IPI00607750   IPI00845371   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIK5
IntAct (EBI)Q9UIK5
FunCoupENSG00000144339
BioGRIDTMEFF2
STRING (EMBL)TMEFF2
ZODIACTMEFF2
Ontologies - Pathways
QuickGOQ9UIK5
Ontology : AmiGOmolecular_function  extracellular region  integral component of membrane  negative regulation of cell migration  wound healing, spreading of cells  negative regulation of integrin biosynthetic process  negative regulation of stress fiber assembly  
Ontology : EGO-EBImolecular_function  extracellular region  integral component of membrane  negative regulation of cell migration  wound healing, spreading of cells  negative regulation of integrin biosynthetic process  negative regulation of stress fiber assembly  
NDEx NetworkTMEFF2
Atlas of Cancer Signalling NetworkTMEFF2
Wikipedia pathwaysTMEFF2
Orthology - Evolution
OrthoDB23671
GeneTree (enSembl)ENSG00000144339
Phylogenetic Trees/Animal Genes : TreeFamTMEFF2
HOVERGENQ9UIK5
HOGENOMQ9UIK5
Homologs : HomoloGeneTMEFF2
Homology/Alignments : Family Browser (UCSC)TMEFF2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)SDPR [2q32.3]  -  TMEFF2 [2q32.3]  [FUSC001633]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEFF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEFF2
dbVarTMEFF2
ClinVarTMEFF2
1000_GenomesTMEFF2 
Exome Variant ServerTMEFF2
ExAC (Exome Aggregation Consortium)TMEFF2 (select the gene name)
Genetic variants : HAPMAP23671
Genomic Variants (DGV)TMEFF2 [DGVbeta]
DECIPHER (Syndromes)2:192813772-193059659  ENSG00000144339
CONAN: Copy Number AnalysisTMEFF2 
Mutations
ICGC Data PortalTMEFF2 
TCGA Data PortalTMEFF2 
Broad Tumor PortalTMEFF2
OASIS PortalTMEFF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEFF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEFF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TMEFF2
DgiDB (Drug Gene Interaction Database)TMEFF2
DoCM (Curated mutations)TMEFF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEFF2 (select a term)
intoGenTMEFF2
Cancer3DTMEFF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605734   
Orphanet
MedgenTMEFF2
Genetic Testing Registry TMEFF2
NextProtQ9UIK5 [Medical]
TSGene23671
GENETestsTMEFF2
Huge Navigator TMEFF2 [HugePedia]
snp3D : Map Gene to Disease23671
BioCentury BCIQTMEFF2
ClinGenTMEFF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23671
Chemical/Pharm GKB GenePA36568
Clinical trialTMEFF2
Miscellaneous
canSAR (ICR)TMEFF2 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEFF2
EVEXTMEFF2
GoPubMedTMEFF2
iHOPTMEFF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:21 CET 2017

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