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TMEM106B (transmembrane protein 106B)

Identity

Alias (NCBI)HLD16
HGNC (Hugo) TMEM106B
HGNC Alias symbMGC33727
FLJ11273
LocusID (NCBI) 54664
Atlas_Id 57836
Location 7p21.3  [Link to chromosome band 7p21]
Location_base_pair Starts at 12211294 and ends at 12243367 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJC21 (5p13.2) / TMEM106B (7p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM106B   22407
Cards
Entrez_Gene (NCBI)TMEM106B    transmembrane protein 106B
AliasesHLD16
GeneCards (Weizmann)TMEM106B
Ensembl hg19 (Hinxton)ENSG00000106460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106460 [Gene_View]  ENSG00000106460 [Sequence]  chr7:12211294-12243367 [Contig_View]  TMEM106B [Vega]
ICGC DataPortalENSG00000106460
TCGA cBioPortalTMEM106B
AceView (NCBI)TMEM106B
Genatlas (Paris)TMEM106B
SOURCE (Princeton)TMEM106B
Genetics Home Reference (NIH)TMEM106B
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM106B  -     chr7:12211294-12243367 +  7p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM106B  -     7p21.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM106B - 7p21.3 [CytoView hg19]  TMEM106B - 7p21.3 [CytoView hg38]
ImmunoBaseENSG00000106460
Genome Data Viewer NCBITMEM106B [Mapview hg19]  
OMIM613413   617964   
Gene and transcription
Genbank (Entrez)AK001834 AK002135 AK090805 AK223263 AK311651
RefSeq transcript (Entrez)NM_001134232 NM_018374
Consensus coding sequences : CCDS (NCBI)TMEM106B
Gene ExpressionTMEM106B [ NCBI-GEO ]   TMEM106B [ EBI - ARRAY_EXPRESS ]   TMEM106B [ SEEK ]   TMEM106B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM106B [ Firebrowse - Broad ]
GenevisibleExpression of TMEM106B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54664
GTEX Portal (Tissue expression)TMEM106B
Human Protein AtlasENSG00000106460-TMEM106B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NUM4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NUM4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NUM4
PhosPhoSitePlusQ9NUM4
Domains : Interpro (EBI)DUF1356_TMEM106   
Domain families : Pfam (Sanger)DUF1356 (PF07092)   
Domain families : Pfam (NCBI)pfam07092   
Conserved Domain (NCBI)TMEM106B
SuperfamilyQ9NUM4
AlphaFold pdb e-kbQ9NUM4   
Human Protein Atlas [tissue]ENSG00000106460-TMEM106B [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9NUM4
IntAct (EBI)Q9NUM4
BioGRIDTMEM106B
STRING (EMBL)TMEM106B
ZODIACTMEM106B
Ontologies - Pathways
QuickGOQ9NUM4
Ontology : AmiGOmolecular_function  protein binding  lysosome  lysosomal membrane  lysosomal membrane  endosome  lysosome organization  lysosomal transport  lysosomal lumen acidification  integral component of membrane  late endosome membrane  lysosome localization  lysosome localization  dendrite morphogenesis  dendrite morphogenesis  ATPase binding  positive regulation of hydrolase activity  positive regulation of dendrite development  lysosomal protein catabolic process  regulation of lysosome organization  
Ontology : EGO-EBImolecular_function  protein binding  lysosome  lysosomal membrane  lysosomal membrane  endosome  lysosome organization  lysosomal transport  lysosomal lumen acidification  integral component of membrane  late endosome membrane  lysosome localization  lysosome localization  dendrite morphogenesis  dendrite morphogenesis  ATPase binding  positive regulation of hydrolase activity  positive regulation of dendrite development  lysosomal protein catabolic process  regulation of lysosome organization  
NDEx NetworkTMEM106B
Atlas of Cancer Signalling NetworkTMEM106B
Wikipedia pathwaysTMEM106B
Orthology - Evolution
OrthoDB54664
GeneTree (enSembl)ENSG00000106460
Phylogenetic Trees/Animal Genes : TreeFamTMEM106B
Homologs : HomoloGeneTMEM106B
Homology/Alignments : Family Browser (UCSC)TMEM106B
Gene fusions - Rearrangements
Fusion : QuiverTMEM106B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM106B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM106B
dbVarTMEM106B
ClinVarTMEM106B
MonarchTMEM106B
1000_GenomesTMEM106B 
Exome Variant ServerTMEM106B
GNOMAD BrowserENSG00000106460
Varsome BrowserTMEM106B
ACMGTMEM106B variants
VarityQ9NUM4
Genomic Variants (DGV)TMEM106B [DGVbeta]
DECIPHERTMEM106B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM106B 
Mutations
ICGC Data PortalTMEM106B 
TCGA Data PortalTMEM106B 
Broad Tumor PortalTMEM106B
OASIS PortalTMEM106B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM106B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM106B
Mutations and Diseases : HGMDTMEM106B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM106B
DgiDB (Drug Gene Interaction Database)TMEM106B
DoCM (Curated mutations)TMEM106B
CIViC (Clinical Interpretations of Variants in Cancer)TMEM106B
Cancer3DTMEM106B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613413    617964   
Orphanet
DisGeNETTMEM106B
MedgenTMEM106B
Genetic Testing Registry TMEM106B
NextProtQ9NUM4 [Medical]
GENETestsTMEM106B
Target ValidationTMEM106B
Huge Navigator TMEM106B [HugePedia]
ClinGenTMEM106B
Clinical trials, drugs, therapy
MyCancerGenomeTMEM106B
Protein Interactions : CTDTMEM106B
Pharm GKB GenePA142670756
PharosQ9NUM4
Clinical trialTMEM106B
Miscellaneous
canSAR (ICR)TMEM106B
HarmonizomeTMEM106B
DataMed IndexTMEM106B
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM106B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:23 CEST 2021

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