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TMEM108 (transmembrane protein 108)

Identity

Alias (NCBI)CT124
RTLN
HGNC (Hugo) TMEM108
HGNC Alias symbMGC3040
CT124
HGNC Alias namecancer/testis antigen 124
LocusID (NCBI) 66000
Atlas_Id 74776
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133038391 and ends at 133397775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDV3 (3q22.1) / TMEM108 (3q22.1)LOC728743 (7q36.1) / TMEM108 (3q22.1)TMEM108 (3q22.1) / CHD3 (17p13.1)
TMEM108 (3q22.1) / GAP43 (3q13.31)TMEM108 (3q22.1) / KLHL1 (13q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM108   28451
Cards
Entrez_Gene (NCBI)TMEM108    transmembrane protein 108
AliasesCT124; RTLN
GeneCards (Weizmann)TMEM108
Ensembl hg19 (Hinxton)ENSG00000144868 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144868 [Gene_View]  ENSG00000144868 [Sequence]  chr3:133038391-133397775 [Contig_View]  TMEM108 [Vega]
ICGC DataPortalENSG00000144868
TCGA cBioPortalTMEM108
AceView (NCBI)TMEM108
Genatlas (Paris)TMEM108
SOURCE (Princeton)TMEM108
Genetics Home Reference (NIH)TMEM108
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM108  -     chr3:133038391-133397775 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM108  -     3q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTMEM108 - 3q22.1 [CytoView hg19]  TMEM108 - 3q22.1 [CytoView hg38]
ImmunoBaseENSG00000144868
Genome Data Viewer NCBITMEM108 [Mapview hg19]  
OMIM617361   
Gene and transcription
Genbank (Entrez)AB051477 AI791245 AK095050 AL136578 AY358381
RefSeq transcript (Entrez)NM_001136469 NM_001282865 NM_023943
Consensus coding sequences : CCDS (NCBI)TMEM108
Gene ExpressionTMEM108 [ NCBI-GEO ]   TMEM108 [ EBI - ARRAY_EXPRESS ]   TMEM108 [ SEEK ]   TMEM108 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM108 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM108 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)66000
GTEX Portal (Tissue expression)TMEM108
Human Protein AtlasENSG00000144868-TMEM108 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXF1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXF1
PhosPhoSitePlusQ6UXF1
Domaine pattern : Prosite (Expaxy)TONB_DEPENDENT_REC_1 (PS00430)   
Domains : Interpro (EBI)TMEM108   
Domain families : Pfam (Sanger)TMEM108 (PF15759)   
Domain families : Pfam (NCBI)pfam15759   
Conserved Domain (NCBI)TMEM108
SuperfamilyQ6UXF1
AlphaFold pdb e-kbQ6UXF1   
Human Protein Atlas [tissue]ENSG00000144868-TMEM108 [tissue]
HPRD11329
Protein Interaction databases
DIP (DOE-UCLA)Q6UXF1
IntAct (EBI)Q6UXF1
BioGRIDTMEM108
STRING (EMBL)TMEM108
ZODIACTMEM108
Ontologies - Pathways
QuickGOQ6UXF1
Ontology : AmiGOmolecular_function  protein binding  cellular_component  early endosome  early endosome  receptor-mediated endocytosis  retrograde axonal transport  retrograde axonal transport  biological_process  endosome membrane  endosome membrane  postsynaptic density  postsynaptic density  integral component of membrane  dentate gyrus development  axon  axon  dendrite  neuron projection development  somatodendritic compartment  positive regulation of neurotrophin TRK receptor signaling pathway  postsynaptic density organization  postsynaptic density organization  dendrite extension  dendrite extension  modulation of excitatory postsynaptic potential  axon cytoplasm  cellular response to brain-derived neurotrophic factor stimulus  
Ontology : EGO-EBImolecular_function  protein binding  cellular_component  early endosome  early endosome  receptor-mediated endocytosis  retrograde axonal transport  retrograde axonal transport  biological_process  endosome membrane  endosome membrane  postsynaptic density  postsynaptic density  integral component of membrane  dentate gyrus development  axon  axon  dendrite  neuron projection development  somatodendritic compartment  positive regulation of neurotrophin TRK receptor signaling pathway  postsynaptic density organization  postsynaptic density organization  dendrite extension  dendrite extension  modulation of excitatory postsynaptic potential  axon cytoplasm  cellular response to brain-derived neurotrophic factor stimulus  
NDEx NetworkTMEM108
Atlas of Cancer Signalling NetworkTMEM108
Wikipedia pathwaysTMEM108
Orthology - Evolution
OrthoDB66000
GeneTree (enSembl)ENSG00000144868
Phylogenetic Trees/Animal Genes : TreeFamTMEM108
Homologs : HomoloGeneTMEM108
Homology/Alignments : Family Browser (UCSC)TMEM108
Gene fusions - Rearrangements
Fusion : QuiverTMEM108
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM108 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM108
dbVarTMEM108
ClinVarTMEM108
MonarchTMEM108
1000_GenomesTMEM108 
Exome Variant ServerTMEM108
GNOMAD BrowserENSG00000144868
Varsome BrowserTMEM108
ACMGTMEM108 variants
VarityQ6UXF1
Genomic Variants (DGV)TMEM108 [DGVbeta]
DECIPHERTMEM108 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM108 
Mutations
ICGC Data PortalTMEM108 
TCGA Data PortalTMEM108 
Broad Tumor PortalTMEM108
OASIS PortalTMEM108 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM108  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM108
Mutations and Diseases : HGMDTMEM108
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM108
DgiDB (Drug Gene Interaction Database)TMEM108
DoCM (Curated mutations)TMEM108
CIViC (Clinical Interpretations of Variants in Cancer)TMEM108
Cancer3DTMEM108
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617361   
Orphanet
DisGeNETTMEM108
MedgenTMEM108
Genetic Testing Registry TMEM108
NextProtQ6UXF1 [Medical]
GENETestsTMEM108
Target ValidationTMEM108
Huge Navigator TMEM108 [HugePedia]
ClinGenTMEM108
Clinical trials, drugs, therapy
MyCancerGenomeTMEM108
Protein Interactions : CTDTMEM108
Pharm GKB GenePA142670759
PharosQ6UXF1
Clinical trialTMEM108
Miscellaneous
canSAR (ICR)TMEM108
HarmonizomeTMEM108
DataMed IndexTMEM108
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM108
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:44 CEST 2021

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