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TMEM108 (transmembrane protein 108)

Identity

Alias_symbol (synonym)MGC3040
CT124
Other aliasRTLN
HGNC (Hugo) TMEM108
LocusID (NCBI) 66000
Atlas_Id 74776
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133038288 and ends at 133397775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDV3 (3q22.1) / TMEM108 (3q22.1)LOC728743 (7q36.1) / TMEM108 (3q22.1)TMEM108 (3q22.1) / CHD3 (17p13.1)
TMEM108 (3q22.1) / GAP43 (3q13.31)TMEM108 (3q22.1) / KLHL1 (13q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM108   28451
Cards
Entrez_Gene (NCBI)TMEM108  66000  transmembrane protein 108
AliasesCT124; RTLN
GeneCards (Weizmann)TMEM108
Ensembl hg19 (Hinxton)ENSG00000144868 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144868 [Gene_View]  chr3:133038288-133397775 [Contig_View]  TMEM108 [Vega]
ICGC DataPortalENSG00000144868
TCGA cBioPortalTMEM108
AceView (NCBI)TMEM108
Genatlas (Paris)TMEM108
WikiGenes66000
SOURCE (Princeton)TMEM108
Genetics Home Reference (NIH)TMEM108
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM108  -     chr3:133038288-133397775 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM108  -     3q22.1   [Description]    (hg19-Feb_2009)
EnsemblTMEM108 - 3q22.1 [CytoView hg19]  TMEM108 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBITMEM108 [Mapview hg19]  TMEM108 [Mapview hg38]
OMIM617361   
Gene and transcription
Genbank (Entrez)AB051477 AI791245 AK095050 AL136578 AY358381
RefSeq transcript (Entrez)NM_001136469 NM_001282865 NM_023943
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM108
Cluster EST : UnigeneHs.191616 [ NCBI ]
CGAP (NCI)Hs.191616
Alternative Splicing GalleryENSG00000144868
Gene ExpressionTMEM108 [ NCBI-GEO ]   TMEM108 [ EBI - ARRAY_EXPRESS ]   TMEM108 [ SEEK ]   TMEM108 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM108 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)66000
GTEX Portal (Tissue expression)TMEM108
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXF1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXF1
Splice isoforms : SwissVarQ6UXF1
PhosPhoSitePlusQ6UXF1
Domains : Interpro (EBI)TMEM108   
Domain families : Pfam (Sanger)TMEM108 (PF15759)   
Domain families : Pfam (NCBI)pfam15759   
Conserved Domain (NCBI)TMEM108
DMDM Disease mutations66000
Blocks (Seattle)TMEM108
SuperfamilyQ6UXF1
Human Protein AtlasENSG00000144868
Peptide AtlasQ6UXF1
HPRD11329
IPIIPI00031907   IPI00792113   IPI00760772   IPI00980339   IPI00978365   IPI00793185   IPI00792652   IPI00791552   
Protein Interaction databases
DIP (DOE-UCLA)Q6UXF1
IntAct (EBI)Q6UXF1
FunCoupENSG00000144868
BioGRIDTMEM108
STRING (EMBL)TMEM108
ZODIACTMEM108
Ontologies - Pathways
QuickGOQ6UXF1
Ontology : AmiGOmolecular_function  cellular_component  early endosome  receptor-mediated endocytosis  retrograde axonal transport  biological_process  endosome membrane  postsynaptic density  integral component of membrane  dentate gyrus development  cell junction  axon  dendrite  neuron projection development  somatodendritic compartment  postsynaptic membrane  positive regulation of neurotrophin TRK receptor signaling pathway  postsynaptic density organization  dendrite extension  modulation of excitatory postsynaptic potential  axon cytoplasm  cellular response to brain-derived neurotrophic factor stimulus  
Ontology : EGO-EBImolecular_function  cellular_component  early endosome  receptor-mediated endocytosis  retrograde axonal transport  biological_process  endosome membrane  postsynaptic density  integral component of membrane  dentate gyrus development  cell junction  axon  dendrite  neuron projection development  somatodendritic compartment  postsynaptic membrane  positive regulation of neurotrophin TRK receptor signaling pathway  postsynaptic density organization  dendrite extension  modulation of excitatory postsynaptic potential  axon cytoplasm  cellular response to brain-derived neurotrophic factor stimulus  
NDEx NetworkTMEM108
Atlas of Cancer Signalling NetworkTMEM108
Wikipedia pathwaysTMEM108
Orthology - Evolution
OrthoDB66000
GeneTree (enSembl)ENSG00000144868
Phylogenetic Trees/Animal Genes : TreeFamTMEM108
HOVERGENQ6UXF1
HOGENOMQ6UXF1
Homologs : HomoloGeneTMEM108
Homology/Alignments : Family Browser (UCSC)TMEM108
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM108 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM108
dbVarTMEM108
ClinVarTMEM108
1000_GenomesTMEM108 
Exome Variant ServerTMEM108
ExAC (Exome Aggregation Consortium)TMEM108 (select the gene name)
Genetic variants : HAPMAP66000
Genomic Variants (DGV)TMEM108 [DGVbeta]
DECIPHERTMEM108 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM108 
Mutations
ICGC Data PortalTMEM108 
TCGA Data PortalTMEM108 
Broad Tumor PortalTMEM108
OASIS PortalTMEM108 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM108  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM108
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM108
DgiDB (Drug Gene Interaction Database)TMEM108
DoCM (Curated mutations)TMEM108 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM108 (select a term)
intoGenTMEM108
Cancer3DTMEM108(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617361   
Orphanet
MedgenTMEM108
Genetic Testing Registry TMEM108
NextProtQ6UXF1 [Medical]
TSGene66000
GENETestsTMEM108
Target ValidationTMEM108
Huge Navigator TMEM108 [HugePedia]
snp3D : Map Gene to Disease66000
BioCentury BCIQTMEM108
ClinGenTMEM108
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD66000
Chemical/Pharm GKB GenePA142670759
Clinical trialTMEM108
Miscellaneous
canSAR (ICR)TMEM108 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM108
EVEXTMEM108
GoPubMedTMEM108
iHOPTMEM108
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:45:47 CEST 2017

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