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TMEM109 (transmembrane protein 109)

Identity

Alias (NCBI)-
HGNC (Hugo) TMEM109
HGNC Alias symbMGC5508
LocusID (NCBI) 79073
Atlas_Id 54705
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60914158 and ends at 60923443 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TKFC (11q12.2) / TMEM109 (11q12.2)TMEM109 (11q12.2) / CTSD (11p15.5)TMEM109 (11q12.2) / TMEM109 (11q12.2)
DAK TMEM109 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM109   28771
Cards
Entrez_Gene (NCBI)TMEM109    transmembrane protein 109
Aliases
GeneCards (Weizmann)TMEM109
Ensembl hg19 (Hinxton)ENSG00000110108 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110108 [Gene_View]  ENSG00000110108 [Sequence]  chr11:60914158-60923443 [Contig_View]  TMEM109 [Vega]
ICGC DataPortalENSG00000110108
TCGA cBioPortalTMEM109
AceView (NCBI)TMEM109
Genatlas (Paris)TMEM109
SOURCE (Princeton)TMEM109
Genetics Home Reference (NIH)TMEM109
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM109  -     chr11:60914158-60923443 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM109  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTMEM109 - 11q12.2 [CytoView hg19]  TMEM109 - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000110108
Genome Data Viewer NCBITMEM109 [Mapview hg19]  
OMIM619168   
Gene and transcription
Genbank (Entrez)AF131803 AK303961 AK313913 AX775849 AX775851
RefSeq transcript (Entrez)NM_024092
Consensus coding sequences : CCDS (NCBI)TMEM109
Gene ExpressionTMEM109 [ NCBI-GEO ]   TMEM109 [ EBI - ARRAY_EXPRESS ]   TMEM109 [ SEEK ]   TMEM109 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM109 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM109 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79073
GTEX Portal (Tissue expression)TMEM109
Human Protein AtlasENSG00000110108-TMEM109 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVC6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVC6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVC6
PhosPhoSitePlusQ9BVC6
Domains : Interpro (EBI)TMEM109   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TMEM109
SuperfamilyQ9BVC6
AlphaFold pdb e-kbQ9BVC6   
Human Protein Atlas [tissue]ENSG00000110108-TMEM109 [tissue]
HPRD14687
Protein Interaction databases
DIP (DOE-UCLA)Q9BVC6
IntAct (EBI)Q9BVC6
BioGRIDTMEM109
STRING (EMBL)TMEM109
ZODIACTMEM109
Ontologies - Pathways
QuickGOQ9BVC6
Ontology : AmiGOmolecular_function  voltage-gated ion channel activity  protein binding  nuclear outer membrane  integral component of membrane  sarcoplasmic reticulum membrane  ion transmembrane transport  regulation of ion transmembrane transport  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of cell death  negative regulation of cell death  extracellular exosome  cellular response to gamma radiation  cellular response to gamma radiation  
Ontology : EGO-EBImolecular_function  voltage-gated ion channel activity  protein binding  nuclear outer membrane  integral component of membrane  sarcoplasmic reticulum membrane  ion transmembrane transport  regulation of ion transmembrane transport  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of cell death  negative regulation of cell death  extracellular exosome  cellular response to gamma radiation  cellular response to gamma radiation  
NDEx NetworkTMEM109
Atlas of Cancer Signalling NetworkTMEM109
Wikipedia pathwaysTMEM109
Orthology - Evolution
OrthoDB79073
GeneTree (enSembl)ENSG00000110108
Phylogenetic Trees/Animal Genes : TreeFamTMEM109
Homologs : HomoloGeneTMEM109
Homology/Alignments : Family Browser (UCSC)TMEM109
Gene fusions - Rearrangements
Fusion : MitelmanTKFC/TMEM109 [11q12.2/11q12.2]  
Fusion : MitelmanTMEM109/CTSD [11q12.2/11p15.5]  
Fusion : QuiverTMEM109
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM109 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM109
dbVarTMEM109
ClinVarTMEM109
MonarchTMEM109
1000_GenomesTMEM109 
Exome Variant ServerTMEM109
GNOMAD BrowserENSG00000110108
Varsome BrowserTMEM109
ACMGTMEM109 variants
VarityQ9BVC6
Genomic Variants (DGV)TMEM109 [DGVbeta]
DECIPHERTMEM109 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM109 
Mutations
ICGC Data PortalTMEM109 
TCGA Data PortalTMEM109 
Broad Tumor PortalTMEM109
OASIS PortalTMEM109 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM109  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM109
Mutations and Diseases : HGMDTMEM109
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM109
DgiDB (Drug Gene Interaction Database)TMEM109
DoCM (Curated mutations)TMEM109
CIViC (Clinical Interpretations of Variants in Cancer)TMEM109
Cancer3DTMEM109
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619168   
Orphanet
DisGeNETTMEM109
MedgenTMEM109
Genetic Testing Registry TMEM109
NextProtQ9BVC6 [Medical]
GENETestsTMEM109
Target ValidationTMEM109
Huge Navigator TMEM109 [HugePedia]
ClinGenTMEM109
Clinical trials, drugs, therapy
MyCancerGenomeTMEM109
Protein Interactions : CTDTMEM109
Pharm GKB GenePA142670760
PharosQ9BVC6
Clinical trialTMEM109
Miscellaneous
canSAR (ICR)TMEM109
HarmonizomeTMEM109
DataMed IndexTMEM109
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM109
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:23 CEST 2021

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