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TMEM109 (transmembrane protein 109)

Identity

Alias_symbol (synonym)MGC5508
Other alias-
HGNC (Hugo) TMEM109
LocusID (NCBI) 79073
Atlas_Id 54705
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60913899 and ends at 60923443 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TKFC (11q12.2) / TMEM109 (11q12.2)TMEM109 (11q12.2) / CTSD (11p15.5)TMEM109 (11q12.2) / TMEM109 (11q12.2)
DAK TMEM109 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM109   28771
Cards
Entrez_Gene (NCBI)TMEM109  79073  transmembrane protein 109
Aliases
GeneCards (Weizmann)TMEM109
Ensembl hg19 (Hinxton)ENSG00000110108 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110108 [Gene_View]  chr11:60913899-60923443 [Contig_View]  TMEM109 [Vega]
ICGC DataPortalENSG00000110108
TCGA cBioPortalTMEM109
AceView (NCBI)TMEM109
Genatlas (Paris)TMEM109
WikiGenes79073
SOURCE (Princeton)TMEM109
Genetics Home Reference (NIH)TMEM109
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM109  -     chr11:60913899-60923443 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM109  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblTMEM109 - 11q12.2 [CytoView hg19]  TMEM109 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBITMEM109 [Mapview hg19]  TMEM109 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF131803 AK303961 AK313913 AX775849 AX775851
RefSeq transcript (Entrez)NM_024092
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM109
Cluster EST : UnigeneHs.13662 [ NCBI ]
CGAP (NCI)Hs.13662
Alternative Splicing GalleryENSG00000110108
Gene ExpressionTMEM109 [ NCBI-GEO ]   TMEM109 [ EBI - ARRAY_EXPRESS ]   TMEM109 [ SEEK ]   TMEM109 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM109 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79073
GTEX Portal (Tissue expression)TMEM109
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVC6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVC6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVC6
Splice isoforms : SwissVarQ9BVC6
PhosPhoSitePlusQ9BVC6
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TMEM109
DMDM Disease mutations79073
Blocks (Seattle)TMEM109
SuperfamilyQ9BVC6
Human Protein AtlasENSG00000110108
Peptide AtlasQ9BVC6
HPRD14687
IPIIPI00031697   IPI00908304   IPI01010350   
Protein Interaction databases
DIP (DOE-UCLA)Q9BVC6
IntAct (EBI)Q9BVC6
FunCoupENSG00000110108
BioGRIDTMEM109
STRING (EMBL)TMEM109
ZODIACTMEM109
Ontologies - Pathways
QuickGOQ9BVC6
Ontology : AmiGOmolecular_function  voltage-gated ion channel activity  nuclear outer membrane  ion transport  integral component of membrane  sarcoplasmic reticulum  sarcoplasmic reticulum membrane  regulation of ion transmembrane transport  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of cell death  extracellular exosome  cellular response to gamma radiation  
Ontology : EGO-EBImolecular_function  voltage-gated ion channel activity  nuclear outer membrane  ion transport  integral component of membrane  sarcoplasmic reticulum  sarcoplasmic reticulum membrane  regulation of i/n trAnslembrane transport  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of cell death  extracellular exosome  cellular response to gamma radiation  
NDEx NetworkTMEM109
Atlas of Cancer Signalling NetworkTMEM109
Wikipedia pathwaysTMEM109
Orthology - Evolution
OrthoDB79073
GeneTree (enSembl)ENSG00000110108
Phylogenetic Trees/Animal Genes : TreeFamTMEM109
HOVERGENQ9BVC6
HOGENOMQ9BVC6
Homologs : HomoloGeneTMEM109
Homology/Alignments : Family Browser (UCSC)TMEM109
Gene fusions - Rearrangements
Fusion : MitelmanTKFC/TMEM109 [11q12.2/11q12.2]  [t(11;11)(q12;q12)]  
Fusion : MitelmanTMEM109/CTSD [11q12.2/11p15.5]  [t(11;11)(p15;q12)]  
Fusion: TCGADAK TMEM109 11q12.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM109 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM109
dbVarTMEM109
ClinVarTMEM109
1000_GenomesTMEM109 
Exome Variant ServerTMEM109
ExAC (Exome Aggregation Consortium)TMEM109 (select the gene name)
Genetic variants : HAPMAP79073
Genomic Variants (DGV)TMEM109 [DGVbeta]
DECIPHERTMEM109 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM109 
Mutations
ICGC Data PortalTMEM109 
TCGA Data PortalTMEM109 
Broad Tumor PortalTMEM109
OASIS PortalTMEM109 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM109  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM109
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM109
DgiDB (Drug Gene Interaction Database)TMEM109
DoCM (Curated mutations)TMEM109 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM109 (select a term)
intoGenTMEM109
Cancer3DTMEM109(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMEM109
Genetic Testing Registry TMEM109
NextProtQ9BVC6 [Medical]
TSGene79073
GENETestsTMEM109
Target ValidationTMEM109
Huge Navigator TMEM109 [HugePedia]
snp3D : Map Gene to Disease79073
BioCentury BCIQTMEM109
ClinGenTMEM109
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79073
Chemical/Pharm GKB GenePA142670760
Clinical trialTMEM109
Miscellaneous
canSAR (ICR)TMEM109 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM109
EVEXTMEM109
GoPubMedTMEM109
iHOPTMEM109
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:35:19 CEST 2017

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