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TMEM115 (transmembrane protein 115)

Identity

Alias_symbol (synonym)PL6
Other alias
HGNC (Hugo) TMEM115
LocusID (NCBI) 11070
Atlas_Id 56501
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50354749 and ends at 50359508 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM115   30055
Cards
Entrez_Gene (NCBI)TMEM115  11070  transmembrane protein 115
AliasesPL6
GeneCards (Weizmann)TMEM115
Ensembl hg19 (Hinxton)ENSG00000126062 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126062 [Gene_View]  chr3:50354749-50359508 [Contig_View]  TMEM115 [Vega]
ICGC DataPortalENSG00000126062
TCGA cBioPortalTMEM115
AceView (NCBI)TMEM115
Genatlas (Paris)TMEM115
WikiGenes11070
SOURCE (Princeton)TMEM115
Genetics Home Reference (NIH)TMEM115
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM115  -     chr3:50354749-50359508 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM115  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblTMEM115 - 3p21.31 [CytoView hg19]  TMEM115 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBITMEM115 [Mapview hg19]  TMEM115 [Mapview hg38]
OMIM607069   
Gene and transcription
Genbank (Entrez)AK314166 BC011948 BC017367 BF305563 CR457020
RefSeq transcript (Entrez)NM_007024
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM115
Cluster EST : UnigeneHs.91566 [ NCBI ]
CGAP (NCI)Hs.91566
Alternative Splicing GalleryENSG00000126062
Gene ExpressionTMEM115 [ NCBI-GEO ]   TMEM115 [ EBI - ARRAY_EXPRESS ]   TMEM115 [ SEEK ]   TMEM115 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM115 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11070
GTEX Portal (Tissue expression)TMEM115
Human Protein AtlasENSG00000126062-TMEM115 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12893   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12893  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12893
Splice isoforms : SwissVarQ12893
PhosPhoSitePlusQ12893
Domains : Interpro (EBI)DUF1751_Mem_euk   
Domain families : Pfam (Sanger)DUF1751 (PF08551)   
Domain families : Pfam (NCBI)pfam08551   
Conserved Domain (NCBI)TMEM115
DMDM Disease mutations11070
Blocks (Seattle)TMEM115
SuperfamilyQ12893
Human Protein Atlas [tissue]ENSG00000126062-TMEM115 [tissue]
Peptide AtlasQ12893
HPRD06144
IPIIPI00170517   
Protein Interaction databases
DIP (DOE-UCLA)Q12893
IntAct (EBI)Q12893
FunCoupENSG00000126062
BioGRIDTMEM115
STRING (EMBL)TMEM115
ZODIACTMEM115
Ontologies - Pathways
QuickGOQ12893
Ontology : AmiGOGolgi membrane  molecular_function  serine-type endopeptidase activity  protein binding  nucleus  Golgi apparatus  protein glycosylation  proteolysis  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  negative regulation of cell proliferation  protein transport  integral component of membrane  Golgi transport complex  Golgi cisterna membrane  identical protein binding  
Ontology : EGO-EBIGolgi membrane  molecular_function  serine-type endopeptidase activity  protein binding  nucleus  Golgi apparatus  protein glycosylation  proteolysis  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  negative regulation of cell proliferation  protein transport  integral component of membrane  Golgi transport complex  Golgi cisterna membrane  identical protein binding  
NDEx NetworkTMEM115
Atlas of Cancer Signalling NetworkTMEM115
Wikipedia pathwaysTMEM115
Orthology - Evolution
OrthoDB11070
GeneTree (enSembl)ENSG00000126062
Phylogenetic Trees/Animal Genes : TreeFamTMEM115
HOVERGENQ12893
HOGENOMQ12893
Homologs : HomoloGeneTMEM115
Homology/Alignments : Family Browser (UCSC)TMEM115
Gene fusions - Rearrangements
Tumor Fusion PortalTMEM115
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM115 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM115
dbVarTMEM115
ClinVarTMEM115
1000_GenomesTMEM115 
Exome Variant ServerTMEM115
ExAC (Exome Aggregation Consortium)ENSG00000126062
GNOMAD BrowserENSG00000126062
Genetic variants : HAPMAP11070
Genomic Variants (DGV)TMEM115 [DGVbeta]
DECIPHERTMEM115 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM115 
Mutations
ICGC Data PortalTMEM115 
TCGA Data PortalTMEM115 
Broad Tumor PortalTMEM115
OASIS PortalTMEM115 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM115  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM115
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM115
DgiDB (Drug Gene Interaction Database)TMEM115
DoCM (Curated mutations)TMEM115 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM115 (select a term)
intoGenTMEM115
Cancer3DTMEM115(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607069   
Orphanet
DisGeNETTMEM115
MedgenTMEM115
Genetic Testing Registry TMEM115
NextProtQ12893 [Medical]
TSGene11070
GENETestsTMEM115
Target ValidationTMEM115
Huge Navigator TMEM115 [HugePedia]
snp3D : Map Gene to Disease11070
BioCentury BCIQTMEM115
ClinGenTMEM115
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11070
Chemical/Pharm GKB GenePA143485636
Clinical trialTMEM115
Miscellaneous
canSAR (ICR)TMEM115 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM115
EVEXTMEM115
GoPubMedTMEM115
iHOPTMEM115
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:43 CET 2017

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