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TMEM119 (transmembrane protein 119)

Identity

Alias (NCBI)OBIF
HGNC (Hugo) TMEM119
HGNC Alias symbOBIF
HGNC Alias nameosteoblast induction factor
LocusID (NCBI) 338773
Atlas_Id 54707
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 108589851 and ends at 108598084 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIKFYVE (2q34) / TMEM119 (12q23.3)TMEM119 (12q23.3) / ARIH2 (3p21.31)TMEM119 (12q23.3) / GAK (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM119   27884
Cards
Entrez_Gene (NCBI)TMEM119    transmembrane protein 119
AliasesOBIF
GeneCards (Weizmann)TMEM119
Ensembl hg19 (Hinxton)ENSG00000183160 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183160 [Gene_View]  ENSG00000183160 [Sequence]  chr12:108589851-108598084 [Contig_View]  TMEM119 [Vega]
ICGC DataPortalENSG00000183160
TCGA cBioPortalTMEM119
AceView (NCBI)TMEM119
Genatlas (Paris)TMEM119
SOURCE (Princeton)TMEM119
Genetics Home Reference (NIH)TMEM119
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM119  -     chr12:108589851-108598084 -  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM119  -     12q23.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM119 - 12q23.3 [CytoView hg19]  TMEM119 - 12q23.3 [CytoView hg38]
ImmunoBaseENSG00000183160
Genome Data Viewer NCBITMEM119 [Mapview hg19]  
OMIM618989   
Gene and transcription
Genbank (Entrez)AK075501 AK097290 AK295288 AK301202 AL521683
RefSeq transcript (Entrez)NM_181724
Consensus coding sequences : CCDS (NCBI)TMEM119
Gene ExpressionTMEM119 [ NCBI-GEO ]   TMEM119 [ EBI - ARRAY_EXPRESS ]   TMEM119 [ SEEK ]   TMEM119 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM119 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM119 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)338773
GTEX Portal (Tissue expression)TMEM119
Human Protein AtlasENSG00000183160-TMEM119 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4V9L6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4V9L6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4V9L6
PhosPhoSitePlusQ4V9L6
Domains : Interpro (EBI)TMEM119   
Domain families : Pfam (Sanger)TMEM119 (PF15724)   
Domain families : Pfam (NCBI)pfam15724   
Conserved Domain (NCBI)TMEM119
SuperfamilyQ4V9L6
AlphaFold pdb e-kbQ4V9L6   
Human Protein Atlas [tissue]ENSG00000183160-TMEM119 [tissue]
HPRD11260
Protein Interaction databases
DIP (DOE-UCLA)Q4V9L6
IntAct (EBI)Q4V9L6
BioGRIDTMEM119
STRING (EMBL)TMEM119
ZODIACTMEM119
Ontologies - Pathways
QuickGOQ4V9L6
Ontology : AmiGOosteoblast differentiation  positive regulation of protein phosphorylation  endochondral ossification  molecular_function  endoplasmic reticulum membrane  plasma membrane  plasma membrane  spermatogenesis  positive regulation of gene expression  negative regulation of myotube differentiation  integral component of membrane  positive regulation of bone mineralization  positive regulation of bone mineralization  biomineral tissue development  positive regulation of osteoblast proliferation  positive regulation of osteoblast proliferation  positive regulation of osteoblast differentiation  positive regulation of osteoblast differentiation  negative regulation of bone resorption  spermatid differentiation  positive regulation of bone development  
Ontology : EGO-EBIosteoblast differentiation  positive regulation of protein phosphorylation  endochondral ossification  molecular_function  endoplasmic reticulum membrane  plasma membrane  plasma membrane  spermatogenesis  positive regulation of gene expression  negative regulation of myotube differentiation  integral component of membrane  positive regulation of bone mineralization  positive regulation of bone mineralization  biomineral tissue development  positive regulation of osteoblast proliferation  positive regulation of osteoblast proliferation  positive regulation of osteoblast differentiation  positive regulation of osteoblast differentiation  negative regulation of bone resorption  spermatid differentiation  positive regulation of bone development  
NDEx NetworkTMEM119
Atlas of Cancer Signalling NetworkTMEM119
Wikipedia pathwaysTMEM119
Orthology - Evolution
OrthoDB338773
GeneTree (enSembl)ENSG00000183160
Phylogenetic Trees/Animal Genes : TreeFamTMEM119
Homologs : HomoloGeneTMEM119
Homology/Alignments : Family Browser (UCSC)TMEM119
Gene fusions - Rearrangements
Fusion : MitelmanPIKFYVE/TMEM119 [2q34/12q23.3]  
Fusion : MitelmanTMEM119/ARIH2 [12q23.3/3p21.31]  
Fusion : QuiverTMEM119
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM119 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM119
dbVarTMEM119
ClinVarTMEM119
MonarchTMEM119
1000_GenomesTMEM119 
Exome Variant ServerTMEM119
GNOMAD BrowserENSG00000183160
Varsome BrowserTMEM119
ACMGTMEM119 variants
VarityQ4V9L6
Genomic Variants (DGV)TMEM119 [DGVbeta]
DECIPHERTMEM119 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM119 
Mutations
ICGC Data PortalTMEM119 
TCGA Data PortalTMEM119 
Broad Tumor PortalTMEM119
OASIS PortalTMEM119 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM119  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM119
Mutations and Diseases : HGMDTMEM119
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM119
DgiDB (Drug Gene Interaction Database)TMEM119
DoCM (Curated mutations)TMEM119
CIViC (Clinical Interpretations of Variants in Cancer)TMEM119
Cancer3DTMEM119
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618989   
Orphanet
DisGeNETTMEM119
MedgenTMEM119
Genetic Testing Registry TMEM119
NextProtQ4V9L6 [Medical]
GENETestsTMEM119
Target ValidationTMEM119
Huge Navigator TMEM119 [HugePedia]
ClinGenTMEM119
Clinical trials, drugs, therapy
MyCancerGenomeTMEM119
Protein Interactions : CTDTMEM119
Pharm GKB GenePA143485640
PharosQ4V9L6
Clinical trialTMEM119
Miscellaneous
canSAR (ICR)TMEM119
HarmonizomeTMEM119
DataMed IndexTMEM119
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM119
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:23 CEST 2021

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