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TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

Identity

Alias (NCBI)D4S2561E
HGNC (Hugo) TMEM129
HGNC Alias symbD4S2561E
HGNC Previous nametransmembrane protein 129, E3 ubiquitin protein ligase
LocusID (NCBI) 92305
Atlas_Id 74790
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 1715952 and ends at 1721357 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM129   25137
Cards
Entrez_Gene (NCBI)TMEM129    transmembrane protein 129, E3 ubiquitin ligase
AliasesD4S2561E
GeneCards (Weizmann)TMEM129
Ensembl hg19 (Hinxton)ENSG00000168936 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168936 [Gene_View]  ENSG00000168936 [Sequence]  chr4:1715952-1721357 [Contig_View]  TMEM129 [Vega]
ICGC DataPortalENSG00000168936
TCGA cBioPortalTMEM129
AceView (NCBI)TMEM129
Genatlas (Paris)TMEM129
SOURCE (Princeton)TMEM129
Genetics Home Reference (NIH)TMEM129
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM129  -     chr4:1715952-1721357 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM129  -     4p16.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM129 - 4p16.3 [CytoView hg19]  TMEM129 - 4p16.3 [CytoView hg38]
ImmunoBaseENSG00000168936
Genome Data Viewer NCBITMEM129 [Mapview hg19]  
OMIM615975   
Gene and transcription
Genbank (Entrez)AK098466 AK303880 AK310320 BC009331 BC018921
RefSeq transcript (Entrez)NM_001127266 NM_138385
Consensus coding sequences : CCDS (NCBI)TMEM129
Gene ExpressionTMEM129 [ NCBI-GEO ]   TMEM129 [ EBI - ARRAY_EXPRESS ]   TMEM129 [ SEEK ]   TMEM129 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM129 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM129 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92305
GTEX Portal (Tissue expression)TMEM129
Human Protein AtlasENSG00000168936-TMEM129 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA0AVI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA0AVI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA0AVI4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusA0AVI4
Domains : Interpro (EBI)TM129   
Domain families : Pfam (Sanger)Tmpp129 (PF10272)   
Domain families : Pfam (NCBI)pfam10272   
Conserved Domain (NCBI)TMEM129
SuperfamilyA0AVI4
AlphaFold pdb e-kbA0AVI4   
Human Protein Atlas [tissue]ENSG00000168936-TMEM129 [tissue]
HPRD14290
Protein Interaction databases
DIP (DOE-UCLA)A0AVI4
IntAct (EBI)A0AVI4
BioGRIDTMEM129
STRING (EMBL)TMEM129
ZODIACTMEM129
Ontologies - Pathways
QuickGOA0AVI4
Ontology : AmiGOprotein polyubiquitination  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  response to unfolded protein  integral component of membrane  protein ubiquitination  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  response to unfolded protein  integral component of membrane  protein ubiquitination  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
NDEx NetworkTMEM129
Atlas of Cancer Signalling NetworkTMEM129
Wikipedia pathwaysTMEM129
Orthology - Evolution
OrthoDB92305
GeneTree (enSembl)ENSG00000168936
Phylogenetic Trees/Animal Genes : TreeFamTMEM129
Homologs : HomoloGeneTMEM129
Homology/Alignments : Family Browser (UCSC)TMEM129
Gene fusions - Rearrangements
Fusion : QuiverTMEM129
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM129 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM129
dbVarTMEM129
ClinVarTMEM129
MonarchTMEM129
1000_GenomesTMEM129 
Exome Variant ServerTMEM129
GNOMAD BrowserENSG00000168936
Varsome BrowserTMEM129
ACMGTMEM129 variants
VarityA0AVI4
Genomic Variants (DGV)TMEM129 [DGVbeta]
DECIPHERTMEM129 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM129 
Mutations
ICGC Data PortalTMEM129 
TCGA Data PortalTMEM129 
Broad Tumor PortalTMEM129
OASIS PortalTMEM129 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM129  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM129
Mutations and Diseases : HGMDTMEM129
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM129
DgiDB (Drug Gene Interaction Database)TMEM129
DoCM (Curated mutations)TMEM129
CIViC (Clinical Interpretations of Variants in Cancer)TMEM129
Cancer3DTMEM129
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615975   
Orphanet
DisGeNETTMEM129
MedgenTMEM129
Genetic Testing Registry TMEM129
NextProtA0AVI4 [Medical]
GENETestsTMEM129
Target ValidationTMEM129
Huge Navigator TMEM129 [HugePedia]
ClinGenTMEM129
Clinical trials, drugs, therapy
MyCancerGenomeTMEM129
Protein Interactions : CTDTMEM129
Pharm GKB GenePA143485649
PharosA0AVI4
Clinical trialTMEM129
Miscellaneous
canSAR (ICR)TMEM129
HarmonizomeTMEM129
DataMed IndexTMEM129
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM129
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:25:47 CEST 2021

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