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TMEM135 (transmembrane protein 135)

Identity

Alias (NCBI)PMP52
HGNC (Hugo) TMEM135
HGNC Alias symbFLJ22104
LocusID (NCBI) 65084
Atlas_Id 74799
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 87037844 and ends at 87328834 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CKAP5 (11p11.2) / TMEM135 (11q14.2)SYTL2 (11q14.1) / TMEM135 (11q14.2)TMEM135 (11q14.2) / AAMDC (11q14.1)
TMEM135 (11q14.2) / ALDH3B2 (11q13.2)TMEM135 (11q14.2) / CCDC81 (11q14.2)TMEM135 (11q14.2) / CHEK1 (11q24.2)
TMEM135 (11q14.2) / CLMP (11q24.1)TMEM135 (11q14.2) / GPD1L (3p22.3)TMEM135 (11q14.2) / TMEM135 (11q14.2)
TMEM135 C11orf67TMEM135 CLMPTMEM135 ALDH3B2
TMEM135 CHEK1TMEM135 GPD1LSYTL2 TMEM135
CKAP5 TMEM135

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(3;11)(p22;q14) TMEM135/GPD1L
t(11;11)(p11;q14) CKAP5/TMEM135
t(11;11)(q13;q14) TMEM135/ALDH3B2
SYTL2/TMEM135 (11q14)
TMEM135/AAMDC (11q14)
t(11;11)(q14;q24) TMEM135/CHEK1
t(11;11)(q14;q24) TMEM135/CLMP

External links

Nomenclature
HGNC (Hugo)TMEM135   26167
Cards
Entrez_Gene (NCBI)TMEM135    transmembrane protein 135
AliasesPMP52
GeneCards (Weizmann)TMEM135
Ensembl hg19 (Hinxton)ENSG00000166575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166575 [Gene_View]  ENSG00000166575 [Sequence]  chr11:87037844-87328834 [Contig_View]  TMEM135 [Vega]
ICGC DataPortalENSG00000166575
TCGA cBioPortalTMEM135
AceView (NCBI)TMEM135
Genatlas (Paris)TMEM135
SOURCE (Princeton)TMEM135
Genetics Home Reference (NIH)TMEM135
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM135  -     chr11:87037844-87328834 +  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM135  -     11q14.2   [Description]    (hg19-Feb_2009)
GoldenPathTMEM135 - 11q14.2 [CytoView hg19]  TMEM135 - 11q14.2 [CytoView hg38]
ImmunoBaseENSG00000166575
genome Data Viewer NCBITMEM135 [Mapview hg19]  
OMIM616360   
Gene and transcription
Genbank (Entrez)AF080569 AK000684 AK024853 AK025757 AK225364
RefSeq transcript (Entrez)NM_001168724 NM_022918
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM135
Alternative Splicing GalleryENSG00000166575
Gene ExpressionTMEM135 [ NCBI-GEO ]   TMEM135 [ EBI - ARRAY_EXPRESS ]   TMEM135 [ SEEK ]   TMEM135 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM135 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM135 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65084
GTEX Portal (Tissue expression)TMEM135
Human Protein AtlasENSG00000166575-TMEM135 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UB9
Splice isoforms : SwissVarQ86UB9
PhosPhoSitePlusQ86UB9
Domains : Interpro (EBI)Tmem135    TMEM135_N   
Domain families : Pfam (Sanger)TMEM135_C_rich (PF15982)   
Domain families : Pfam (NCBI)pfam15982   
Conserved Domain (NCBI)TMEM135
Blocks (Seattle)TMEM135
SuperfamilyQ86UB9
Human Protein Atlas [tissue]ENSG00000166575-TMEM135 [tissue]
Peptide AtlasQ86UB9
HPRD07978
IPIIPI00384207   IPI00465106   IPI00976130   IPI00977426   IPI01012146   IPI00975465   
Protein Interaction databases
DIP (DOE-UCLA)Q86UB9
IntAct (EBI)Q86UB9
BioGRIDTMEM135
STRING (EMBL)TMEM135
ZODIACTMEM135
Ontologies - Pathways
QuickGOQ86UB9
Ontology : AmiGOperoxisome  peroxisomal membrane  lipid droplet  peroxisome organization  response to cold  integral component of membrane  mitochondrial membrane  response to food  regulation of mitochondrial fission  
Ontology : EGO-EBIperoxisome  peroxisomal membrane  lipid droplet  peroxisome organization  response to cold  integral component of membrane  mitochondrial membrane  response to food  regulation of mitochondrial fission  
NDEx NetworkTMEM135
Atlas of Cancer Signalling NetworkTMEM135
Wikipedia pathwaysTMEM135
Orthology - Evolution
OrthoDB65084
GeneTree (enSembl)ENSG00000166575
Phylogenetic Trees/Animal Genes : TreeFamTMEM135
HOGENOMQ86UB9
Homologs : HomoloGeneTMEM135
Homology/Alignments : Family Browser (UCSC)TMEM135
Gene fusions - Rearrangements
Fusion PortalTMEM135 C11orf67
Fusion PortalTMEM135 CLMP
Fusion PortalTMEM135 ALDH3B2
Fusion PortalTMEM135 CHEK1
Fusion PortalTMEM135 GPD1L
Fusion PortalSYTL2 TMEM135
Fusion PortalCKAP5 TMEM135
Fusion : QuiverTMEM135
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM135 [hg38]
dbVarTMEM135
ClinVarTMEM135
MonarchTMEM135
1000_GenomesTMEM135 
Exome Variant ServerTMEM135
GNOMAD BrowserENSG00000166575
Varsome BrowserTMEM135
Genomic Variants (DGV)TMEM135 [DGVbeta]
DECIPHERTMEM135 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM135 
Mutations
ICGC Data PortalTMEM135 
TCGA Data PortalTMEM135 
Broad Tumor PortalTMEM135
OASIS PortalTMEM135 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM135  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM135
Mutations and Diseases : HGMDTMEM135
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM135
DgiDB (Drug Gene Interaction Database)TMEM135
DoCM (Curated mutations)TMEM135 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM135 (select a term)
intoGenTMEM135
Cancer3DTMEM135(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616360   
Orphanet
DisGeNETTMEM135
MedgenTMEM135
Genetic Testing Registry TMEM135
NextProtQ86UB9 [Medical]
GENETestsTMEM135
Target ValidationTMEM135
Huge Navigator TMEM135 [HugePedia]
ClinGenTMEM135
Clinical trials, drugs, therapy
MyCancerGenomeTMEM135
Protein Interactions : CTD
Pharm GKB GenePA143485658
Clinical trialTMEM135
Miscellaneous
canSAR (ICR)TMEM135 (select the gene name)
HarmonizomeTMEM135
DataMed IndexTMEM135
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM135
EVEXTMEM135
GoPubMedTMEM135
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:32:01 CET 2020
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