Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TMEM14B (transmembrane protein 14B)

Identity

Other alias-
HGNC (Hugo) TMEM14B
LocusID (NCBI) 81853
Atlas_Id 57304
Location 6p24.2  [Link to chromosome band 6p24]
Location_base_pair Starts at 10747759 and ends at 10756981 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAX5 (9p13.2) / TMEM14B (6p24.2)RAPGEF5 (7p15.3) / TMEM14B (6p24.2)TMEM14B (6p24.2) / CAPRIN1 (11p13)
TMEM14B (6p24.2) / CUX1 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p24;p13) PAX5/TMEM14B


External links

Nomenclature
HGNC (Hugo)TMEM14B   21384
Cards
Entrez_Gene (NCBI)TMEM14B  81853  transmembrane protein 14B
Aliases
GeneCards (Weizmann)TMEM14B
Ensembl hg19 (Hinxton)ENSG00000137210 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137210 [Gene_View]  ENSG00000137210 [Sequence]  chr6:10747759-10756981 [Contig_View]  TMEM14B [Vega]
ICGC DataPortalENSG00000137210
TCGA cBioPortalTMEM14B
AceView (NCBI)TMEM14B
Genatlas (Paris)TMEM14B
WikiGenes81853
SOURCE (Princeton)TMEM14B
Genetics Home Reference (NIH)TMEM14B
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM14B  -     chr6:10747759-10756981 +  6p24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM14B  -     6p24.2   [Description]    (hg19-Feb_2009)
EnsemblTMEM14B - 6p24.2 [CytoView hg19]  TMEM14B - 6p24.2 [CytoView hg38]
Mapping of homologs : NCBITMEM14B [Mapview hg19]  TMEM14B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI343263 AK291883 AK294152 AK311340 BC001033
RefSeq transcript (Entrez)NM_001127711 NM_001286484 NM_001286488 NM_001286489 NM_030969
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM14B
Cluster EST : UnigeneHs.667371 [ NCBI ]
CGAP (NCI)Hs.667371
Alternative Splicing GalleryENSG00000137210
Gene ExpressionTMEM14B [ NCBI-GEO ]   TMEM14B [ EBI - ARRAY_EXPRESS ]   TMEM14B [ SEEK ]   TMEM14B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM14B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81853
GTEX Portal (Tissue expression)TMEM14B
Human Protein AtlasENSG00000137210-TMEM14B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NUH8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NUH8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NUH8
Splice isoforms : SwissVarQ9NUH8
PhosPhoSitePlusQ9NUH8
Domains : Interpro (EBI)TMEM14   
Domain families : Pfam (Sanger)Tmemb_14 (PF03647)   
Domain families : Pfam (NCBI)pfam03647   
Conserved Domain (NCBI)TMEM14B
DMDM Disease mutations81853
Blocks (Seattle)TMEM14B
SuperfamilyQ9NUH8
Human Protein Atlas [tissue]ENSG00000137210-TMEM14B [tissue]
Peptide AtlasQ9NUH8
IPIIPI00300744   IPI00513922   IPI00946534   IPI00945763   IPI00908794   IPI00946383   IPI00946697   IPI00945604   IPI00945394   IPI00944916   IPI00945958   
Protein Interaction databases
DIP (DOE-UCLA)Q9NUH8
IntAct (EBI)Q9NUH8
FunCoupENSG00000137210
BioGRIDTMEM14B
STRING (EMBL)TMEM14B
ZODIACTMEM14B
Ontologies - Pathways
QuickGOQ9NUH8
Ontology : AmiGOprotein binding  integral component of membrane  cerebral cortex development  neural precursor cell proliferation  regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIprotein binding  integral component of membrane  cerebral cortex development  neural precursor cell proliferation  regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkTMEM14B
Atlas of Cancer Signalling NetworkTMEM14B
Wikipedia pathwaysTMEM14B
Orthology - Evolution
OrthoDB81853
GeneTree (enSembl)ENSG00000137210
Phylogenetic Trees/Animal Genes : TreeFamTMEM14B
HOVERGENQ9NUH8
HOGENOMQ9NUH8
Homologs : HomoloGeneTMEM14B
Homology/Alignments : Family Browser (UCSC)TMEM14B
Gene fusions - Rearrangements
Fusion : QuiverTMEM14B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM14B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM14B
dbVarTMEM14B
ClinVarTMEM14B
1000_GenomesTMEM14B 
Exome Variant ServerTMEM14B
ExAC (Exome Aggregation Consortium)ENSG00000137210
GNOMAD BrowserENSG00000137210
Varsome BrowserTMEM14B
Genetic variants : HAPMAP81853
Genomic Variants (DGV)TMEM14B [DGVbeta]
DECIPHERTMEM14B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM14B 
Mutations
ICGC Data PortalTMEM14B 
TCGA Data PortalTMEM14B 
Broad Tumor PortalTMEM14B
OASIS PortalTMEM14B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM14B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM14B
BioMutasearch TMEM14B
DgiDB (Drug Gene Interaction Database)TMEM14B
DoCM (Curated mutations)TMEM14B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM14B (select a term)
intoGenTMEM14B
Cancer3DTMEM14B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMEM14B
MedgenTMEM14B
Genetic Testing Registry TMEM14B
NextProtQ9NUH8 [Medical]
TSGene81853
GENETestsTMEM14B
Target ValidationTMEM14B
Huge Navigator TMEM14B [HugePedia]
snp3D : Map Gene to Disease81853
BioCentury BCIQTMEM14B
ClinGenTMEM14B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81853
Chemical/Pharm GKB GenePA134964501
Clinical trialTMEM14B
Miscellaneous
canSAR (ICR)TMEM14B (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM14B
EVEXTMEM14B
GoPubMedTMEM14B
iHOPTMEM14B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:45:29 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.