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TMEM159 (transmembrane protein 159)

Identity

Alias (NCBI)-
HGNC (Hugo) TMEM159
HGNC Alias symbpromethin
LocusID (NCBI) 57146
Atlas_Id 74821
Location 16p12.3  [Link to chromosome band 16p12]
Location_base_pair Starts at 21158377 and ends at 21180616 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JAK2 (9p24.1) / TMEM159 (16p12.3)TMEM159 (16p12.3) / DNAH3 (16p12.3)UBFD1 (16p12.2) / TMEM159 (16p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TMEM159/DNAH3 (16p12)
UBFD1/TMEM159 (16p12)

External links

Nomenclature
HGNC (Hugo)TMEM159   30136
Cards
Entrez_Gene (NCBI)TMEM159  57146  transmembrane protein 159
Aliases
GeneCards (Weizmann)TMEM159
Ensembl hg19 (Hinxton)ENSG00000011638 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011638 [Gene_View]  ENSG00000011638 [Sequence]  chr16:21158377-21180616 [Contig_View]  TMEM159 [Vega]
ICGC DataPortalENSG00000011638
TCGA cBioPortalTMEM159
AceView (NCBI)TMEM159
Genatlas (Paris)TMEM159
WikiGenes57146
SOURCE (Princeton)TMEM159
Genetics Home Reference (NIH)TMEM159
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM159  -     chr16:21158377-21180616 +  16p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM159  -     16p12.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM159 - 16p12.3 [CytoView hg19]  TMEM159 - 16p12.3 [CytoView hg38]
ImmunoBaseENSG00000011638
genome Data Viewer NCBITMEM159 [Mapview hg19]  
OMIM611304   
Gene and transcription
Genbank (Entrez)AF070596 AI968069 AK074667 AK293557 AL694739
RefSeq transcript (Entrez)NM_001301769 NM_001301771 NM_001301773 NM_001301774 NM_001301775 NM_020422
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM159
Alternative Splicing GalleryENSG00000011638
Gene ExpressionTMEM159 [ NCBI-GEO ]   TMEM159 [ EBI - ARRAY_EXPRESS ]   TMEM159 [ SEEK ]   TMEM159 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM159 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM159 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57146
GTEX Portal (Tissue expression)TMEM159
Human Protein AtlasENSG00000011638-TMEM159 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96B96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96B96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96B96
Splice isoforms : SwissVarQ96B96
PhosPhoSitePlusQ96B96
Domains : Interpro (EBI)Promethin/TMEM159   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TMEM159
DMDM Disease mutations57146
Blocks (Seattle)TMEM159
SuperfamilyQ96B96
Human Protein Atlas [tissue]ENSG00000011638-TMEM159 [tissue]
Peptide AtlasQ96B96
HPRD17428
IPIIPI00298405   IPI00646518   
Protein Interaction databases
DIP (DOE-UCLA)Q96B96
IntAct (EBI)Q96B96
FunCoupENSG00000011638
BioGRIDTMEM159
STRING (EMBL)TMEM159
ZODIACTMEM159
Ontologies - Pathways
QuickGOQ96B96
Ontology : AmiGOprotein binding  integral component of membrane  
Ontology : EGO-EBIprotein binding  integral component of membrane  
NDEx NetworkTMEM159
Atlas of Cancer Signalling NetworkTMEM159
Wikipedia pathwaysTMEM159
Orthology - Evolution
OrthoDB57146
GeneTree (enSembl)ENSG00000011638
Phylogenetic Trees/Animal Genes : TreeFamTMEM159
HOGENOMQ96B96
Homologs : HomoloGeneTMEM159
Homology/Alignments : Family Browser (UCSC)TMEM159
Gene fusions - Rearrangements
Fusion : QuiverTMEM159
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM159 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM159
dbVarTMEM159
ClinVarTMEM159
1000_GenomesTMEM159 
Exome Variant ServerTMEM159
GNOMAD BrowserENSG00000011638
Varsome BrowserTMEM159
Genetic variants : HAPMAP57146
Genomic Variants (DGV)TMEM159 [DGVbeta]
DECIPHERTMEM159 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM159 
Mutations
ICGC Data PortalTMEM159 
TCGA Data PortalTMEM159 
Broad Tumor PortalTMEM159
OASIS PortalTMEM159 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM159  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM159
Mutations and Diseases : HGMDTMEM159
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM159
DgiDB (Drug Gene Interaction Database)TMEM159
DoCM (Curated mutations)TMEM159 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM159 (select a term)
intoGenTMEM159
Cancer3DTMEM159(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611304   
Orphanet
DisGeNETTMEM159
MedgenTMEM159
Genetic Testing Registry TMEM159
NextProtQ96B96 [Medical]
TSGene57146
GENETestsTMEM159
Target ValidationTMEM159
Huge Navigator TMEM159 [HugePedia]
snp3D : Map Gene to Disease57146
BioCentury BCIQTMEM159
ClinGenTMEM159
Clinical trials, drugs, therapy
Protein Interactions : CTD57146
Pharm GKB GenePA145147935
Clinical trialTMEM159
Miscellaneous
canSAR (ICR)TMEM159 (select the gene name)
HarmonizomeTMEM159
DataMed IndexTMEM159
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM159
EVEXTMEM159
GoPubMedTMEM159
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:32:59 CEST 2020
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