Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TMEM173 (transmembrane protein 173)

Identity

Alias_symbol (synonym)FLJ38577
NET23
Other aliasERIS
MITA
MPYS
SAVI
STING
hMITA
hSTING
HGNC (Hugo) TMEM173
LocusID (NCBI) 340061
Atlas_Id 52153
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139475528 and ends at 139482302 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM173 (5q31.2) / OLA1 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM173   27962
Cards
Entrez_Gene (NCBI)TMEM173  340061  transmembrane protein 173
AliasesERIS; MITA; MPYS; NET23; 
SAVI; STING; hMITA; hSTING
GeneCards (Weizmann)TMEM173
Ensembl hg19 (Hinxton)ENSG00000184584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184584 [Gene_View]  chr5:139475528-139482302 [Contig_View]  TMEM173 [Vega]
ICGC DataPortalENSG00000184584
TCGA cBioPortalTMEM173
AceView (NCBI)TMEM173
Genatlas (Paris)TMEM173
WikiGenes340061
SOURCE (Princeton)TMEM173
Genetics Home Reference (NIH)TMEM173
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM173  -     chr5:139475528-139482302 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM173  -     5q31.2   [Description]    (hg19-Feb_2009)
EnsemblTMEM173 - 5q31.2 [CytoView hg19]  TMEM173 - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBITMEM173 [Mapview hg19]  TMEM173 [Mapview hg38]
OMIM612374   615934   
Gene and transcription
Genbank (Entrez)AK095896 AK129800 AK290661 AX775913 BC047779
RefSeq transcript (Entrez)NM_001301738 NM_198282
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM173
Cluster EST : UnigeneHs.379754 [ NCBI ]
CGAP (NCI)Hs.379754
Alternative Splicing GalleryENSG00000184584
Gene ExpressionTMEM173 [ NCBI-GEO ]   TMEM173 [ EBI - ARRAY_EXPRESS ]   TMEM173 [ SEEK ]   TMEM173 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM173 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340061
GTEX Portal (Tissue expression)TMEM173
Human Protein AtlasENSG00000184584-TMEM173 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WV6
Splice isoforms : SwissVarQ86WV6
PhosPhoSitePlusQ86WV6
Domains : Interpro (EBI)STING    STING_C   
Domain families : Pfam (Sanger)TMEM173 (PF15009)   
Domain families : Pfam (NCBI)pfam15009   
Conserved Domain (NCBI)TMEM173
DMDM Disease mutations340061
Blocks (Seattle)TMEM173
PDB (SRS)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
PDB (PDBSum)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
PDB (IMB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
PDB (RSDB)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
Structural Biology KnowledgeBase4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
SCOP (Structural Classification of Proteins)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
CATH (Classification of proteins structures)4EF4    4EF5    4EMT    4EMU    4F5D    4F5E    4F5W    4F5Y    4F9E    4F9G    4KSY    4LOH    4LOI    4QXO    4QXP    4QXQ    4QXR    5BQX    5JEJ   
SuperfamilyQ86WV6
Human Protein Atlas [tissue]ENSG00000184584-TMEM173 [tissue]
Peptide AtlasQ86WV6
HPRD14173
IPIIPI00257059   IPI00964330   
Protein Interaction databases
DIP (DOE-UCLA)Q86WV6
IntAct (EBI)Q86WV6
FunCoupENSG00000184584
BioGRIDTMEM173
STRING (EMBL)TMEM173
ZODIACTMEM173
Ontologies - Pathways
QuickGOQ86WV6
Ontology : AmiGOactivation of innate immune response  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  apoptotic process  transcription factor binding  integral component of membrane  protein kinase binding  protein kinase binding  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  interferon-beta production  interferon-beta production  positive regulation of protein import into nucleus, translocation  cyclic-di-GMP binding  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  positive regulation of transcription factor import into nucleus  neutrophil degranulation  innate immune response  innate immune response  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  
Ontology : EGO-EBIactivation of innate immune response  positive regulation of defense response to virus by host  protein binding  nucleoplasm  mitochondrial outer membrane  peroxisome  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  apoptotic process  transcription factor binding  integral component of membrane  protein kinase binding  protein kinase binding  cytoplasmic vesicle membrane  secretory granule membrane  ubiquitin protein ligase binding  positive regulation of protein binding  regulation of type I interferon production  positive regulation of type I interferon production  positive regulation of type I interferon production  interferon-beta production  interferon-beta production  positive regulation of protein import into nucleus, translocation  cyclic-di-GMP binding  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  positive regulation of transcription factor import into nucleus  neutrophil degranulation  innate immune response  innate immune response  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  defense response to virus  cyclic-GMP-AMP binding  cyclic-GMP-AMP binding  cellular response to exogenous dsRNA  cellular response to organic cyclic compound  
Pathways : KEGGRIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway   
NDEx NetworkTMEM173
Atlas of Cancer Signalling NetworkTMEM173
Wikipedia pathwaysTMEM173
Orthology - Evolution
OrthoDB340061
GeneTree (enSembl)ENSG00000184584
Phylogenetic Trees/Animal Genes : TreeFamTMEM173
HOVERGENQ86WV6
HOGENOMQ86WV6
Homologs : HomoloGeneTMEM173
Homology/Alignments : Family Browser (UCSC)TMEM173
Gene fusions - Rearrangements
Tumor Fusion PortalTMEM173
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM173 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM173
dbVarTMEM173
ClinVarTMEM173
1000_GenomesTMEM173 
Exome Variant ServerTMEM173
ExAC (Exome Aggregation Consortium)ENSG00000184584
GNOMAD BrowserENSG00000184584
Genetic variants : HAPMAP340061
Genomic Variants (DGV)TMEM173 [DGVbeta]
DECIPHERTMEM173 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM173 
Mutations
ICGC Data PortalTMEM173 
TCGA Data PortalTMEM173 
Broad Tumor PortalTMEM173
OASIS PortalTMEM173 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM173  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM173
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM173
DgiDB (Drug Gene Interaction Database)TMEM173
DoCM (Curated mutations)TMEM173 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM173 (select a term)
intoGenTMEM173
Cancer3DTMEM173(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612374    615934   
Orphanet23209   
DisGeNETTMEM173
MedgenTMEM173
Genetic Testing Registry TMEM173
NextProtQ86WV6 [Medical]
TSGene340061
GENETestsTMEM173
Target ValidationTMEM173
Huge Navigator TMEM173 [HugePedia]
snp3D : Map Gene to Disease340061
BioCentury BCIQTMEM173
ClinGenTMEM173
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD340061
Chemical/Pharm GKB GenePA162405934
Clinical trialTMEM173
Miscellaneous
canSAR (ICR)TMEM173 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM173
EVEXTMEM173
GoPubMedTMEM173
iHOPTMEM173
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:38:46 CET 2017

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