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TMEM175 (transmembrane protein 175)

Identity

Alias (NCBI)hTMEM175
HGNC (Hugo) TMEM175
HGNC Alias symbMGC4618
LocusID (NCBI) 84286
Atlas_Id 56000
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 932460 and ends at 958655 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG6 (6p21.33) / TMEM175 (4p16.3)TMEM175 (4p16.3) / BAG6 (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMEM175   28709
Cards
Entrez_Gene (NCBI)TMEM175    transmembrane protein 175
AliaseshTMEM175
GeneCards (Weizmann)TMEM175
Ensembl hg19 (Hinxton)ENSG00000127419 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127419 [Gene_View]  ENSG00000127419 [Sequence]  chr4:932460-958655 [Contig_View]  TMEM175 [Vega]
ICGC DataPortalENSG00000127419
TCGA cBioPortalTMEM175
AceView (NCBI)TMEM175
Genatlas (Paris)TMEM175
SOURCE (Princeton)TMEM175
Genetics Home Reference (NIH)TMEM175
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM175  -     chr4:932460-958655 +  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM175  -     4p16.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM175 - 4p16.3 [CytoView hg19]  TMEM175 - 4p16.3 [CytoView hg38]
ImmunoBaseENSG00000127419
Genome Data Viewer NCBITMEM175 [Mapview hg19]  
OMIM616660   
Gene and transcription
Genbank (Entrez)AK090848 AK293641 AK309132 AL834199 BC005158
RefSeq transcript (Entrez)NM_001297423 NM_001297424 NM_001297425 NM_001297426 NM_001297427 NM_001297428 NM_032326
Consensus coding sequences : CCDS (NCBI)TMEM175
Gene ExpressionTMEM175 [ NCBI-GEO ]   TMEM175 [ EBI - ARRAY_EXPRESS ]   TMEM175 [ SEEK ]   TMEM175 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM175 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM175 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84286
GTEX Portal (Tissue expression)TMEM175
Human Protein AtlasENSG00000127419-TMEM175 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BSA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BSA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BSA9
PhosPhoSitePlusQ9BSA9
Domains : Interpro (EBI)TMEM175   
Domain families : Pfam (Sanger)DUF1211 (PF06736)   
Domain families : Pfam (NCBI)pfam06736   
Conserved Domain (NCBI)TMEM175
PDB (RSDB)6WC9    6WCA    6WCB    6WCC   
PDB Europe6WC9    6WCA    6WCB    6WCC   
PDB (PDBSum)6WC9    6WCA    6WCB    6WCC   
PDB (IMB)6WC9    6WCA    6WCB    6WCC   
Structural Biology KnowledgeBase6WC9    6WCA    6WCB    6WCC   
SCOP (Structural Classification of Proteins)6WC9    6WCA    6WCB    6WCC   
CATH (Classification of proteins structures)6WC9    6WCA    6WCB    6WCC   
SuperfamilyQ9BSA9
AlphaFold pdb e-kbQ9BSA9   
Human Protein Atlas [tissue]ENSG00000127419-TMEM175 [tissue]
HPRD14648
Protein Interaction databases
DIP (DOE-UCLA)Q9BSA9
IntAct (EBI)Q9BSA9
BioGRIDTMEM175
STRING (EMBL)TMEM175
ZODIACTMEM175
Ontologies - Pathways
QuickGOQ9BSA9
Ontology : AmiGOpotassium channel activity  protein binding  lysosome  lysosome  lysosomal membrane  endosome  endosome  potassium ion leak channel activity  potassium ion leak channel activity  integral component of endosome membrane  regulation of lysosomal lumen pH  neuron cellular homeostasis  potassium ion transmembrane transport  phagosome-lysosome fusion  integral component of lysosomal membrane  
Ontology : EGO-EBIpotassium channel activity  protein binding  lysosome  lysosome  lysosomal membrane  endosome  endosome  potassium ion leak channel activity  potassium ion leak channel activity  integral component of endosome membrane  regulation of lysosomal lumen pH  neuron cellular homeostasis  potassium ion transmembrane transport  phagosome-lysosome fusion  integral component of lysosomal membrane  
NDEx NetworkTMEM175
Atlas of Cancer Signalling NetworkTMEM175
Wikipedia pathwaysTMEM175
Orthology - Evolution
OrthoDB84286
GeneTree (enSembl)ENSG00000127419
Phylogenetic Trees/Animal Genes : TreeFamTMEM175
Homologs : HomoloGeneTMEM175
Homology/Alignments : Family Browser (UCSC)TMEM175
Gene fusions - Rearrangements
Fusion : QuiverTMEM175
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM175 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM175
dbVarTMEM175
ClinVarTMEM175
MonarchTMEM175
1000_GenomesTMEM175 
Exome Variant ServerTMEM175
GNOMAD BrowserENSG00000127419
Varsome BrowserTMEM175
ACMGTMEM175 variants
VarityQ9BSA9
Genomic Variants (DGV)TMEM175 [DGVbeta]
DECIPHERTMEM175 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM175 
Mutations
ICGC Data PortalTMEM175 
TCGA Data PortalTMEM175 
Broad Tumor PortalTMEM175
OASIS PortalTMEM175 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM175  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM175
Mutations and Diseases : HGMDTMEM175
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM175
DgiDB (Drug Gene Interaction Database)TMEM175
DoCM (Curated mutations)TMEM175
CIViC (Clinical Interpretations of Variants in Cancer)TMEM175
Cancer3DTMEM175
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616660   
Orphanet
DisGeNETTMEM175
MedgenTMEM175
Genetic Testing Registry TMEM175
NextProtQ9BSA9 [Medical]
GENETestsTMEM175
Target ValidationTMEM175
Huge Navigator TMEM175 [HugePedia]
ClinGenTMEM175
Clinical trials, drugs, therapy
MyCancerGenomeTMEM175
Protein Interactions : CTDTMEM175
Pharm GKB GenePA162405946
PharosQ9BSA9
Clinical trialTMEM175
Miscellaneous
canSAR (ICR)TMEM175
HarmonizomeTMEM175
DataMed IndexTMEM175
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM175
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:26 CEST 2021

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