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TMEM176B (transmembrane protein 176B)

Identity

Alias_symbol (synonym)LR8
MS4B2
Other alias
HGNC (Hugo) TMEM176B
LocusID (NCBI) 28959
Atlas_Id 52943
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 150791288 and ends at 150800533 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM176B (7q36.1) / MRPS18B (6p21.33)TMEM176B (7q36.1) / SNIP1 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM176B   29596
Cards
Entrez_Gene (NCBI)TMEM176B  28959  transmembrane protein 176B
AliasesLR8; MS4B2
GeneCards (Weizmann)TMEM176B
Ensembl hg19 (Hinxton)ENSG00000106565 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106565 [Gene_View]  chr7:150791288-150800533 [Contig_View]  TMEM176B [Vega]
ICGC DataPortalENSG00000106565
TCGA cBioPortalTMEM176B
AceView (NCBI)TMEM176B
Genatlas (Paris)TMEM176B
WikiGenes28959
SOURCE (Princeton)TMEM176B
Genetics Home Reference (NIH)TMEM176B
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM176B  -     chr7:150791288-150800533 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM176B  -     7q36.1   [Description]    (hg19-Feb_2009)
EnsemblTMEM176B - 7q36.1 [CytoView hg19]  TMEM176B - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBITMEM176B [Mapview hg19]  TMEM176B [Mapview hg38]
OMIM610385   
Gene and transcription
Genbank (Entrez)AF115384 AK000841 AK097304 AK129525 AK315575
RefSeq transcript (Entrez)NM_001101311 NM_001101312 NM_001101313 NM_001101314 NM_014020
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM176B
Cluster EST : UnigeneHs.709505 [ NCBI ]
CGAP (NCI)Hs.709505
Alternative Splicing GalleryENSG00000106565
Gene ExpressionTMEM176B [ NCBI-GEO ]   TMEM176B [ EBI - ARRAY_EXPRESS ]   TMEM176B [ SEEK ]   TMEM176B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM176B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28959
GTEX Portal (Tissue expression)TMEM176B
Human Protein AtlasENSG00000106565-TMEM176B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3YBM2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3YBM2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3YBM2
Splice isoforms : SwissVarQ3YBM2
PhosPhoSitePlusQ3YBM2
Domains : Interpro (EBI)CD20-like    TMEM176A/TMEM176B   
Domain families : Pfam (Sanger)CD20 (PF04103)   
Domain families : Pfam (NCBI)pfam04103   
Conserved Domain (NCBI)TMEM176B
DMDM Disease mutations28959
Blocks (Seattle)TMEM176B
SuperfamilyQ3YBM2
Human Protein Atlas [tissue]ENSG00000106565-TMEM176B [tissue]
Peptide AtlasQ3YBM2
HPRD17443
IPIIPI00106808   IPI00855842   
Protein Interaction databases
DIP (DOE-UCLA)Q3YBM2
IntAct (EBI)Q3YBM2
FunCoupENSG00000106565
BioGRIDTMEM176B
STRING (EMBL)TMEM176B
ZODIACTMEM176B
Ontologies - Pathways
QuickGOQ3YBM2
Ontology : AmiGOanimal organ morphogenesis  integral component of membrane  cell differentiation  nuclear membrane  negative regulation of dendritic cell differentiation  
Ontology : EGO-EBIanimal organ morphogenesis  integral component of membrane  cell differentiation  nuclear membrane  negative regulation of dendritic cell differentiation  
NDEx NetworkTMEM176B
Atlas of Cancer Signalling NetworkTMEM176B
Wikipedia pathwaysTMEM176B
Orthology - Evolution
OrthoDB28959
GeneTree (enSembl)ENSG00000106565
Phylogenetic Trees/Animal Genes : TreeFamTMEM176B
HOVERGENQ3YBM2
HOGENOMQ3YBM2
Homologs : HomoloGeneTMEM176B
Homology/Alignments : Family Browser (UCSC)TMEM176B
Gene fusions - Rearrangements
Tumor Fusion PortalTMEM176B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM176B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM176B
dbVarTMEM176B
ClinVarTMEM176B
1000_GenomesTMEM176B 
Exome Variant ServerTMEM176B
ExAC (Exome Aggregation Consortium)ENSG00000106565
GNOMAD BrowserENSG00000106565
Genetic variants : HAPMAP28959
Genomic Variants (DGV)TMEM176B [DGVbeta]
DECIPHERTMEM176B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM176B 
Mutations
ICGC Data PortalTMEM176B 
TCGA Data PortalTMEM176B 
Broad Tumor PortalTMEM176B
OASIS PortalTMEM176B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM176B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM176B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM176B
DgiDB (Drug Gene Interaction Database)TMEM176B
DoCM (Curated mutations)TMEM176B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM176B (select a term)
intoGenTMEM176B
Cancer3DTMEM176B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610385   
Orphanet
DisGeNETTMEM176B
MedgenTMEM176B
Genetic Testing Registry TMEM176B
NextProtQ3YBM2 [Medical]
TSGene28959
GENETestsTMEM176B
Target ValidationTMEM176B
Huge Navigator TMEM176B [HugePedia]
snp3D : Map Gene to Disease28959
BioCentury BCIQTMEM176B
ClinGenTMEM176B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28959
Chemical/Pharm GKB GenePA162405966
Clinical trialTMEM176B
Miscellaneous
canSAR (ICR)TMEM176B (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM176B
EVEXTMEM176B
GoPubMedTMEM176B
iHOPTMEM176B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:46 CET 2017

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