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TMEM18 (transmembrane protein 18)

Identity

Alias (NCBI)lncND
HGNC (Hugo) TMEM18
HGNC Alias symbDKFZp434C1714
lncND
LocusID (NCBI) 129787
Atlas_Id 53977
Location 2p25.3  [Link to chromosome band 2p25]
Location_base_pair Starts at 663878 and ends at 677406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM18 (2p25.3) / TLE3 (15q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;20)(p25;q11) TMEM18/ASXL1


External links

 

Nomenclature
HGNC (Hugo)TMEM18   25257
Cards
Entrez_Gene (NCBI)TMEM18    transmembrane protein 18
AliaseslncND
GeneCards (Weizmann)TMEM18
Ensembl hg19 (Hinxton)ENSG00000151353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151353 [Gene_View]  ENSG00000151353 [Sequence]  chr2:663878-677406 [Contig_View]  TMEM18 [Vega]
ICGC DataPortalENSG00000151353
TCGA cBioPortalTMEM18
AceView (NCBI)TMEM18
Genatlas (Paris)TMEM18
SOURCE (Princeton)TMEM18
Genetics Home Reference (NIH)TMEM18
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM18  -     chr2:663878-677406 -  2p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM18  -     2p25.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM18 - 2p25.3 [CytoView hg19]  TMEM18 - 2p25.3 [CytoView hg38]
ImmunoBaseENSG00000151353
Genome Data Viewer NCBITMEM18 [Mapview hg19]  
OMIM613220   
Gene and transcription
Genbank (Entrez)AA280711 AI272939 AK125009 AL137269 BC016010
RefSeq transcript (Entrez)NM_001352680 NM_001352681 NM_152834
Consensus coding sequences : CCDS (NCBI)TMEM18
Gene ExpressionTMEM18 [ NCBI-GEO ]   TMEM18 [ EBI - ARRAY_EXPRESS ]   TMEM18 [ SEEK ]   TMEM18 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM18 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129787
GTEX Portal (Tissue expression)TMEM18
Human Protein AtlasENSG00000151353-TMEM18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96B42   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96B42  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96B42
PhosPhoSitePlusQ96B42
Domains : Interpro (EBI)TMEM18   
Domain families : Pfam (Sanger)TMEM18 (PF14770)   
Domain families : Pfam (NCBI)pfam14770   
Conserved Domain (NCBI)TMEM18
SuperfamilyQ96B42
AlphaFold pdb e-kbQ96B42   
Human Protein Atlas [tissue]ENSG00000151353-TMEM18 [tissue]
HPRD15529
Protein Interaction databases
DIP (DOE-UCLA)Q96B42
IntAct (EBI)Q96B42
BioGRIDTMEM18
STRING (EMBL)TMEM18
ZODIACTMEM18
Ontologies - Pathways
QuickGOQ96B42
Ontology : AmiGODNA binding  cytoplasm  integral component of membrane  cell migration  nuclear membrane  
Ontology : EGO-EBIDNA binding  cytoplasm  integral component of membrane  cell migration  nuclear membrane  
NDEx NetworkTMEM18
Atlas of Cancer Signalling NetworkTMEM18
Wikipedia pathwaysTMEM18
Orthology - Evolution
OrthoDB129787
GeneTree (enSembl)ENSG00000151353
Phylogenetic Trees/Animal Genes : TreeFamTMEM18
Homologs : HomoloGeneTMEM18
Homology/Alignments : Family Browser (UCSC)TMEM18
Gene fusions - Rearrangements
Fusion : QuiverTMEM18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM18
dbVarTMEM18
ClinVarTMEM18
MonarchTMEM18
1000_GenomesTMEM18 
Exome Variant ServerTMEM18
GNOMAD BrowserENSG00000151353
Varsome BrowserTMEM18
ACMGTMEM18 variants
VarityQ96B42
Genomic Variants (DGV)TMEM18 [DGVbeta]
DECIPHERTMEM18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM18 
Mutations
ICGC Data PortalTMEM18 
TCGA Data PortalTMEM18 
Broad Tumor PortalTMEM18
OASIS PortalTMEM18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM18
Mutations and Diseases : HGMDTMEM18
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM18
DgiDB (Drug Gene Interaction Database)TMEM18
DoCM (Curated mutations)TMEM18
CIViC (Clinical Interpretations of Variants in Cancer)TMEM18
Cancer3DTMEM18
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613220   
Orphanet
DisGeNETTMEM18
MedgenTMEM18
Genetic Testing Registry TMEM18
NextProtQ96B42 [Medical]
GENETestsTMEM18
Target ValidationTMEM18
Huge Navigator TMEM18 [HugePedia]
ClinGenTMEM18
Clinical trials, drugs, therapy
MyCancerGenomeTMEM18
Protein Interactions : CTDTMEM18
Pharm GKB GenePA134873089
PharosQ96B42
Clinical trialTMEM18
Miscellaneous
canSAR (ICR)TMEM18
HarmonizomeTMEM18
DataMed IndexTMEM18
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:27 CEST 2021

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