Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TMEM25 (transmembrane protein 25)

Identity

Alias (NCBI)-
HGNC (Hugo) TMEM25
HGNC Alias symbFLJ14399
LocusID (NCBI) 84866
Atlas_Id 51234
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118531192 and ends at 118535829 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM25 (11q23.3) / CDH26 (20q13.33)TMEM25 (11q23.3) / TECTA (11q23.3)WDR74 (11q12.3) / TMEM25 (11q23.3)
TMEM25 11q23.3 / CDH26 20q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;20)(q23;q13) TMEM25/CDH26

External links

Nomenclature
HGNC (Hugo)TMEM25   25890
Cards
Entrez_Gene (NCBI)TMEM25  84866  transmembrane protein 25
Aliases
GeneCards (Weizmann)TMEM25
Ensembl hg19 (Hinxton)ENSG00000149582 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149582 [Gene_View]  ENSG00000149582 [Sequence]  chr11:118531192-118535829 [Contig_View]  TMEM25 [Vega]
ICGC DataPortalENSG00000149582
TCGA cBioPortalTMEM25
AceView (NCBI)TMEM25
Genatlas (Paris)TMEM25
WikiGenes84866
SOURCE (Princeton)TMEM25
Genetics Home Reference (NIH)TMEM25
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM25  -     chr11:118531192-118535829 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM25  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM25 - 11q23.3 [CytoView hg19]  TMEM25 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000149582
genome Data Viewer NCBITMEM25 [Mapview hg19]  
OMIM613934   
Gene and transcription
Genbank (Entrez)AK027305 AK056325 AK075437 AK096260 AK124814
RefSeq transcript (Entrez)NM_001144034 NM_001144035 NM_001144036 NM_001144037 NM_001144038 NM_001318755 NM_001318757 NM_032780
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM25
Alternative Splicing GalleryENSG00000149582
Gene ExpressionTMEM25 [ NCBI-GEO ]   TMEM25 [ EBI - ARRAY_EXPRESS ]   TMEM25 [ SEEK ]   TMEM25 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM25 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM25 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84866
GTEX Portal (Tissue expression)TMEM25
Human Protein AtlasENSG00000149582-TMEM25 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YD3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YD3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YD3
Splice isoforms : SwissVarQ86YD3
PhosPhoSitePlusQ86YD3
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    TMEM25   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)   
Domain families : Pfam (NCBI)pfam08205   
Conserved Domain (NCBI)TMEM25
DMDM Disease mutations84866
Blocks (Seattle)TMEM25
SuperfamilyQ86YD3
Human Protein Atlas [tissue]ENSG00000149582-TMEM25 [tissue]
Peptide AtlasQ86YD3
HPRD11635
IPIIPI00162329   IPI00419599   IPI00043469   IPI00478247   IPI00922575   IPI00921110   IPI00984433   IPI00981099   IPI00981063   IPI00983081   IPI00983695   IPI00985005   IPI00981761   IPI00977589   IPI00976935   IPI00982766   
Protein Interaction databases
DIP (DOE-UCLA)Q86YD3
IntAct (EBI)Q86YD3
FunCoupENSG00000149582
BioGRIDTMEM25
STRING (EMBL)TMEM25
ZODIACTMEM25
Ontologies - Pathways
QuickGOQ86YD3
Ontology : AmiGOprotein binding  extracellular region  lysosome  late endosome  plasma membrane  integral component of membrane  regulation of protein stability  negative regulation of excitatory postsynaptic potential  negative regulation of excitatory postsynaptic potential  
Ontology : EGO-EBIprotein binding  extracellular region  lysosome  late endosome  plasma membrane  integral component of membrane  regulation of protein stability  negative regulation of excitatory postsynaptic potential  negative regulation of excitatory postsynaptic potential  
NDEx NetworkTMEM25
Atlas of Cancer Signalling NetworkTMEM25
Wikipedia pathwaysTMEM25
Orthology - Evolution
OrthoDB84866
GeneTree (enSembl)ENSG00000149582
Phylogenetic Trees/Animal Genes : TreeFamTMEM25
HOGENOMQ86YD3
Homologs : HomoloGeneTMEM25
Homology/Alignments : Family Browser (UCSC)TMEM25
Gene fusions - Rearrangements
Fusion : MitelmanTMEM25/CDH26 [11q23.3/20q13.33]  
Fusion PortalTMEM25 11q23.3 CDH26 20q13.33 BRCA
Fusion : QuiverTMEM25
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM25
dbVarTMEM25
ClinVarTMEM25
MonarchTMEM25
1000_GenomesTMEM25 
Exome Variant ServerTMEM25
GNOMAD BrowserENSG00000149582
Varsome BrowserTMEM25
Genetic variants : HAPMAP84866
Genomic Variants (DGV)TMEM25 [DGVbeta]
DECIPHERTMEM25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM25 
Mutations
ICGC Data PortalTMEM25 
TCGA Data PortalTMEM25 
Broad Tumor PortalTMEM25
OASIS PortalTMEM25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM25  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM25
Mutations and Diseases : HGMDTMEM25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM25
DgiDB (Drug Gene Interaction Database)TMEM25
DoCM (Curated mutations)TMEM25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM25 (select a term)
intoGenTMEM25
Cancer3DTMEM25(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613934   
Orphanet
DisGeNETTMEM25
MedgenTMEM25
Genetic Testing Registry TMEM25
NextProtQ86YD3 [Medical]
TSGene84866
GENETestsTMEM25
Target ValidationTMEM25
Huge Navigator TMEM25 [HugePedia]
snp3D : Map Gene to Disease84866
BioCentury BCIQTMEM25
ClinGenTMEM25
Clinical trials, drugs, therapy
Protein Interactions : CTD84866
Pharm GKB GenePA134919013
Clinical trialTMEM25
Miscellaneous
canSAR (ICR)TMEM25 (select the gene name)
HarmonizomeTMEM25
DataMed IndexTMEM25
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM25
EVEXTMEM25
GoPubMedTMEM25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:36:27 CEST 2020
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