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TMEM259 (transmembrane protein 259)

Identity

Alias_namesC19orf6
chromosome 19 open reading frame 6
Alias_symbol (synonym)MGC4022
ASBABP1
MBRL
Other aliasMEMBRALIN
R32184_3
HGNC (Hugo) TMEM259
LocusID (NCBI) 91304
Atlas_Id 46191
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1009650 and ends at 1021141 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TMEM259 (19p13.3) / ATP5J2-PTCD1 (7q22.1)TMEM259 (19p13.3) / CCDC25 (8p21.1)TMEM259 (19p13.3) / FASN (17q25.3)
TMEM259 (19p13.3) / MBOAT7 (19q13.42)TMEM259 (19p13.3) / NCL (2q37.1)TMEM259 (19p13.3) / NMT1 (17q21.31)
TMEM259 (19p13.3) / SBNO2 (19p13.3)TMEM259 (19p13.3) / TMEM259 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM259   17039
Cards
Entrez_Gene (NCBI)TMEM259  91304  transmembrane protein 259
AliasesASBABP1; C19orf6; MBRL; MEMBRALIN; 
R32184_3
GeneCards (Weizmann)TMEM259
Ensembl hg19 (Hinxton)ENSG00000182087 [Gene_View]  chr19:1009650-1021141 [Contig_View]  TMEM259 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182087 [Gene_View]  chr19:1009650-1021141 [Contig_View]  TMEM259 [Vega]
ICGC DataPortalENSG00000182087
TCGA cBioPortalTMEM259
AceView (NCBI)TMEM259
Genatlas (Paris)TMEM259
WikiGenes91304
SOURCE (Princeton)TMEM259
Genetics Home Reference (NIH)TMEM259
Genomic and cartography
GoldenPath hg19 (UCSC)TMEM259  -     chr19:1009650-1021141 -  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMEM259  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblTMEM259 - 19p13.3 [CytoView hg19]  TMEM259 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITMEM259 [Mapview hg19]  TMEM259 [Mapview hg38]
OMIM611011   
Gene and transcription
Genbank (Entrez)AK090400 AK095756 AY140906 BC008957 BQ895919
RefSeq transcript (Entrez)NM_001033026 NM_033420
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)TMEM259
Cluster EST : UnigeneHs.515003 [ NCBI ]
CGAP (NCI)Hs.515003
Alternative Splicing GalleryENSG00000182087
Gene ExpressionTMEM259 [ NCBI-GEO ]   TMEM259 [ EBI - ARRAY_EXPRESS ]   TMEM259 [ SEEK ]   TMEM259 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM259 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91304
GTEX Portal (Tissue expression)TMEM259
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4ZIN3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4ZIN3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4ZIN3
Splice isoforms : SwissVarQ4ZIN3
PhosPhoSitePlusQ4ZIN3
Domains : Interpro (EBI)Membralin   
Domain families : Pfam (Sanger)Membralin (PF09746)   
Domain families : Pfam (NCBI)pfam09746   
Conserved Domain (NCBI)TMEM259
DMDM Disease mutations91304
Blocks (Seattle)TMEM259
SuperfamilyQ4ZIN3
Human Protein AtlasENSG00000182087
Peptide AtlasQ4ZIN3
HPRD12710
IPIIPI00386199   IPI00396541   IPI00816758   
Protein Interaction databases
DIP (DOE-UCLA)Q4ZIN3
IntAct (EBI)Q4ZIN3
FunCoupENSG00000182087
BioGRIDTMEM259
STRING (EMBL)TMEM259
ZODIACTMEM259
Ontologies - Pathways
QuickGOQ4ZIN3
Ontology : AmiGOendoplasmic reticulum membrane  integral component of membrane  response to endoplasmic reticulum stress  negative regulation of neuron death  positive regulation of ERAD pathway  
Ontology : EGO-EBIendoplasmic reticulum membrane  integral component of membrane  response to endoplasmic reticulum stress  negative regulation of neuron death  positive regulation of ERAD pathway  
NDEx NetworkTMEM259
Atlas of Cancer Signalling NetworkTMEM259
Wikipedia pathwaysTMEM259
Orthology - Evolution
OrthoDB91304
GeneTree (enSembl)ENSG00000182087
Phylogenetic Trees/Animal Genes : TreeFamTMEM259
HOVERGENQ4ZIN3
HOGENOMQ4ZIN3
Homologs : HomoloGeneTMEM259
Homology/Alignments : Family Browser (UCSC)TMEM259
Gene fusions - Rearrangements
Fusion : MitelmanTMEM259/CCDC25 [19p13.3/8p21.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM259 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM259
dbVarTMEM259
ClinVarTMEM259
1000_GenomesTMEM259 
Exome Variant ServerTMEM259
ExAC (Exome Aggregation Consortium)TMEM259 (select the gene name)
Genetic variants : HAPMAP91304
Genomic Variants (DGV)TMEM259 [DGVbeta]
DECIPHER (Syndromes)19:1009650-1021141  ENSG00000182087
CONAN: Copy Number AnalysisTMEM259 
Mutations
ICGC Data PortalTMEM259 
TCGA Data PortalTMEM259 
Broad Tumor PortalTMEM259
OASIS PortalTMEM259 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTMEM259
BioMutasearch TMEM259
DgiDB (Drug Gene Interaction Database)TMEM259
DoCM (Curated mutations)TMEM259 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM259 (select a term)
intoGenTMEM259
Cancer3DTMEM259(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611011   
Orphanet
MedgenTMEM259
Genetic Testing Registry TMEM259
NextProtQ4ZIN3 [Medical]
TSGene91304
GENETestsTMEM259
Huge Navigator TMEM259 [HugePedia]
snp3D : Map Gene to Disease91304
BioCentury BCIQTMEM259
ClinGenTMEM259
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91304
Chemical/Pharm GKB GenePA134936083
Clinical trialTMEM259
Miscellaneous
canSAR (ICR)TMEM259 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM259
EVEXTMEM259
GoPubMedTMEM259
iHOPTMEM259
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:22:45 CEST 2017

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