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TMEM259 (transmembrane protein 259)

Identity

Alias (NCBI)ASBABP1
C19orf6
MBRL
MEMBRALIN
R32184_3
HGNC (Hugo) TMEM259
HGNC Alias symbMGC4022
ASBABP1
MBRL
HGNC Alias namemembralin
 aspecific BCL2 ARE-binding protein 1
HGNC Previous nameC19orf6
HGNC Previous namechromosome 19 open reading frame 6
LocusID (NCBI) 91304
Atlas_Id 46191
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1009653 and ends at 1021123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM259 (19p13.3) / ATP5J2-PTCD1 (7q22.1)TMEM259 (19p13.3) / CCDC25 (8p21.1)TMEM259 (19p13.3) / FASN (17q25.3)
TMEM259 (19p13.3) / MBOAT7 (19q13.42)TMEM259 (19p13.3) / NCL (2q37.1)TMEM259 (19p13.3) / NMT1 (17q21.31)
TMEM259 (19p13.3) / SBNO2 (19p13.3)TMEM259 (19p13.3) / TMEM259 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(p13;p13) PTBP1/TMEM259


External links

 

Nomenclature
HGNC (Hugo)TMEM259   17039
Cards
Entrez_Gene (NCBI)TMEM259    transmembrane protein 259
AliasesASBABP1; C19orf6; MBRL; MEMBRALIN; 
R32184_3
GeneCards (Weizmann)TMEM259
Ensembl hg19 (Hinxton)ENSG00000182087 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182087 [Gene_View]  ENSG00000182087 [Sequence]  chr19:1009653-1021123 [Contig_View]  TMEM259 [Vega]
ICGC DataPortalENSG00000182087
TCGA cBioPortalTMEM259
AceView (NCBI)TMEM259
Genatlas (Paris)TMEM259
SOURCE (Princeton)TMEM259
Genetics Home Reference (NIH)TMEM259
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM259  -     chr19:1009653-1021123 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM259  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTMEM259 - 19p13.3 [CytoView hg19]  TMEM259 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000182087
Genome Data Viewer NCBITMEM259 [Mapview hg19]  
OMIM611011   
Gene and transcription
Genbank (Entrez)AK090400 AK095756 AY140906 BC008957 BQ895919
RefSeq transcript (Entrez)NM_001033026 NM_033420
Consensus coding sequences : CCDS (NCBI)TMEM259
Gene ExpressionTMEM259 [ NCBI-GEO ]   TMEM259 [ EBI - ARRAY_EXPRESS ]   TMEM259 [ SEEK ]   TMEM259 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM259 [ Firebrowse - Broad ]
GenevisibleExpression of TMEM259 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91304
GTEX Portal (Tissue expression)TMEM259
Human Protein AtlasENSG00000182087-TMEM259 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4ZIN3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4ZIN3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4ZIN3
PhosPhoSitePlusQ4ZIN3
Domains : Interpro (EBI)Membralin   
Domain families : Pfam (Sanger)Membralin (PF09746)   
Domain families : Pfam (NCBI)pfam09746   
Conserved Domain (NCBI)TMEM259
SuperfamilyQ4ZIN3
AlphaFold pdb e-kbQ4ZIN3   
Human Protein Atlas [tissue]ENSG00000182087-TMEM259 [tissue]
HPRD12710
Protein Interaction databases
DIP (DOE-UCLA)Q4ZIN3
IntAct (EBI)Q4ZIN3
BioGRIDTMEM259
STRING (EMBL)TMEM259
ZODIACTMEM259
Ontologies - Pathways
QuickGOQ4ZIN3
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  response to endoplasmic reticulum stress  negative regulation of neuron death  positive regulation of ERAD pathway  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  response to endoplasmic reticulum stress  negative regulation of neuron death  positive regulation of ERAD pathway  
NDEx NetworkTMEM259
Atlas of Cancer Signalling NetworkTMEM259
Wikipedia pathwaysTMEM259
Orthology - Evolution
OrthoDB91304
GeneTree (enSembl)ENSG00000182087
Phylogenetic Trees/Animal Genes : TreeFamTMEM259
Homologs : HomoloGeneTMEM259
Homology/Alignments : Family Browser (UCSC)TMEM259
Gene fusions - Rearrangements
Fusion : MitelmanTMEM259/CCDC25 [19p13.3/8p21.1]  
Fusion : QuiverTMEM259
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM259 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM259
dbVarTMEM259
ClinVarTMEM259
MonarchTMEM259
1000_GenomesTMEM259 
Exome Variant ServerTMEM259
GNOMAD BrowserENSG00000182087
Varsome BrowserTMEM259
ACMGTMEM259 variants
VarityQ4ZIN3
Genomic Variants (DGV)TMEM259 [DGVbeta]
DECIPHERTMEM259 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM259 
Mutations
ICGC Data PortalTMEM259 
TCGA Data PortalTMEM259 
Broad Tumor PortalTMEM259
OASIS PortalTMEM259 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM259  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM259
Mutations and Diseases : HGMDTMEM259
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMEM259
DgiDB (Drug Gene Interaction Database)TMEM259
DoCM (Curated mutations)TMEM259
CIViC (Clinical Interpretations of Variants in Cancer)TMEM259
Cancer3DTMEM259
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611011   
Orphanet
DisGeNETTMEM259
MedgenTMEM259
Genetic Testing Registry TMEM259
NextProtQ4ZIN3 [Medical]
GENETestsTMEM259
Target ValidationTMEM259
Huge Navigator TMEM259 [HugePedia]
ClinGenTMEM259
Clinical trials, drugs, therapy
MyCancerGenomeTMEM259
Protein Interactions : CTDTMEM259
Pharm GKB GenePA134936083
PharosQ4ZIN3
Clinical trialTMEM259
Miscellaneous
canSAR (ICR)TMEM259
HarmonizomeTMEM259
DataMed IndexTMEM259
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMEM259
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:30 CEST 2021

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