Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TMEM52B (transmembrane protein 52B)

Identity

Alias (NCBI)C12orf59
HGNC (Hugo) TMEM52B
HGNC Alias symbFLJ31166
HGNC Previous nameC12orf59
HGNC Previous namechromosome 12 open reading frame 59
LocusID (NCBI) 120939
Atlas_Id 54712
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10179032 and ends at 10191804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM52B (12p13.2) / XIAP (Xq25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;12)(q25;p13) TMEM52B/XIAP

External links

Nomenclature
HGNC (Hugo)TMEM52B   26438
Cards
Entrez_Gene (NCBI)TMEM52B  120939  transmembrane protein 52B
AliasesC12orf59
GeneCards (Weizmann)TMEM52B
Ensembl hg19 (Hinxton)ENSG00000165685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165685 [Gene_View]  ENSG00000165685 [Sequence]  chr12:10179032-10191804 [Contig_View]  TMEM52B [Vega]
ICGC DataPortalENSG00000165685
TCGA cBioPortalTMEM52B
AceView (NCBI)TMEM52B
Genatlas (Paris)TMEM52B
WikiGenes120939
SOURCE (Princeton)TMEM52B
Genetics Home Reference (NIH)TMEM52B
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM52B  -     chr12:10179032-10191804 +  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM52B  -     12p13.2   [Description]    (hg19-Feb_2009)
GoldenPathTMEM52B - 12p13.2 [CytoView hg19]  TMEM52B - 12p13.2 [CytoView hg38]
ImmunoBaseENSG00000165685
genome Data Viewer NCBITMEM52B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK055728 AY358845 BC098571 BC131523 BE301029
RefSeq transcript (Entrez)NM_001079815 NM_153022
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM52B
Alternative Splicing GalleryENSG00000165685
Gene ExpressionTMEM52B [ NCBI-GEO ]   TMEM52B [ EBI - ARRAY_EXPRESS ]   TMEM52B [ SEEK ]   TMEM52B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM52B [ Firebrowse - Broad ]
GenevisibleExpression of TMEM52B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)120939
GTEX Portal (Tissue expression)TMEM52B
Human Protein AtlasENSG00000165685-TMEM52B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4KMG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4KMG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4KMG9
Splice isoforms : SwissVarQ4KMG9
PhosPhoSitePlusQ4KMG9
Domains : Interpro (EBI)TMEM52   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TMEM52B
DMDM Disease mutations120939
Blocks (Seattle)TMEM52B
SuperfamilyQ4KMG9
Human Protein Atlas [tissue]ENSG00000165685-TMEM52B [tissue]
Peptide AtlasQ4KMG9
HPRD08709
IPIIPI00619937   IPI00043559   IPI01013715   
Protein Interaction databases
DIP (DOE-UCLA)Q4KMG9
IntAct (EBI)Q4KMG9
FunCoupENSG00000165685
BioGRIDTMEM52B
STRING (EMBL)TMEM52B
ZODIACTMEM52B
Ontologies - Pathways
QuickGOQ4KMG9
Ontology : AmiGOmolecular_function  biological_process  integral component of membrane  extracellular exosome  
Ontology : EGO-EBImolecular_function  biological_process  integral component of membrane  extracellular exosome  
NDEx NetworkTMEM52B
Atlas of Cancer Signalling NetworkTMEM52B
Wikipedia pathwaysTMEM52B
Orthology - Evolution
OrthoDB120939
GeneTree (enSembl)ENSG00000165685
Phylogenetic Trees/Animal Genes : TreeFamTMEM52B
HOGENOMQ4KMG9
Homologs : HomoloGeneTMEM52B
Homology/Alignments : Family Browser (UCSC)TMEM52B
Gene fusions - Rearrangements
Fusion : MitelmanTMEM52B/XIAP [12p13.2/Xq25]  
Fusion : QuiverTMEM52B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM52B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM52B
dbVarTMEM52B
ClinVarTMEM52B
MonarchTMEM52B
1000_GenomesTMEM52B 
Exome Variant ServerTMEM52B
GNOMAD BrowserENSG00000165685
Varsome BrowserTMEM52B
Genetic variants : HAPMAP120939
Genomic Variants (DGV)TMEM52B [DGVbeta]
DECIPHERTMEM52B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM52B 
Mutations
ICGC Data PortalTMEM52B 
TCGA Data PortalTMEM52B 
Broad Tumor PortalTMEM52B
OASIS PortalTMEM52B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM52B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMEM52B
Mutations and Diseases : HGMDTMEM52B
BioMutasearch TMEM52B
DgiDB (Drug Gene Interaction Database)TMEM52B
DoCM (Curated mutations)TMEM52B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM52B (select a term)
intoGenTMEM52B
Cancer3DTMEM52B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMEM52B
MedgenTMEM52B
Genetic Testing Registry TMEM52B
NextProtQ4KMG9 [Medical]
TSGene120939
GENETestsTMEM52B
Target ValidationTMEM52B
Huge Navigator TMEM52B [HugePedia]
snp3D : Map Gene to Disease120939
BioCentury BCIQTMEM52B
ClinGenTMEM52B
Clinical trials, drugs, therapy
Protein Interactions : CTD120939
Pharm GKB GenePA143485388
Clinical trialTMEM52B
Miscellaneous
canSAR (ICR)TMEM52B (select the gene name)
HarmonizomeTMEM52B
DataMed IndexTMEM52B
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM52B
EVEXTMEM52B
GoPubMedTMEM52B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 14 14:36:29 CEST 2020
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