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TMEM59 (transmembrane protein 59)

Identity

Alias_namesC1orf8
chromosome 1 open reading frame 8
Alias_symbol (synonym)HSPC001
Other aliasDCF1
PRO195
UNQ169
HGNC (Hugo) TMEM59
LocusID (NCBI) 9528
Atlas_Id 74961
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 54026681 and ends at 54053438 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		HYOU1 (11q23.3) / TMEM59 (1p32.3)MYO9A (15q23) / TMEM59 (1p32.3)TMEM59 (1p32.3) / CLN8 (8p23.3)
TMEM59 (1p32.3) / MDGA2 (14q21.3)TMEM59 (1p32.3) / MYBPC1 (12q23.2)TMEM59 (1p32.3) / TMEM59 (1p32.3)
TSPAN1 (1p34.1) / TMEM59 (1p32.3)YIPF1 (1p32.3) / TMEM59 (1p32.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TMEM59   1239
Cards
Entrez_Gene (NCBI)TMEM59  9528  transmembrane protein 59
AliasesC1orf8; DCF1; HSPC001; PRO195; 
UNQ169
GeneCards (Weizmann)TMEM59
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:54026681-54053438 [Contig_View]  TMEM59 [Vega]
TCGA cBioPortalTMEM59
AceView (NCBI)TMEM59
Genatlas (Paris)TMEM59
WikiGenes9528
SOURCE (Princeton)TMEM59
Genetics Home Reference (NIH)TMEM59
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM59  -     chr1:54026681-54053438 -  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM59  -     1p32.3   [Description]    (hg19-Feb_2009)
EnsemblTMEM59 - 1p32.3 [CytoView hg19]  TMEM59 - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBITMEM59 [Mapview hg19]  TMEM59 [Mapview hg38]
OMIM617084   
Gene and transcription
Genbank (Entrez)AF047439 AF086356 AF290615 AK027328 AK057652
RefSeq transcript (Entrez)NM_001305043 NM_001305049 NM_001305050 NM_001305051 NM_001305052 NM_001305066 NM_004872
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM59
Cluster EST : UnigeneHs.689423 [ NCBI ]
CGAP (NCI)Hs.689423
Gene ExpressionTMEM59 [ NCBI-GEO ]   TMEM59 [ EBI - ARRAY_EXPRESS ]   TMEM59 [ SEEK ]   TMEM59 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM59 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9528
GTEX Portal (Tissue expression)TMEM59
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXS4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXS4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXS4
Splice isoforms : SwissVarQ9BXS4
PhosPhoSitePlusQ9BXS4
Domains : Interpro (EBI)Uncharacterised_TMEM59   
Domain families : Pfam (Sanger)BSMAP (PF12280)   
Domain families : Pfam (NCBI)pfam12280   
Conserved Domain (NCBI)TMEM59
DMDM Disease mutations9528
Blocks (Seattle)TMEM59
SuperfamilyQ9BXS4
Peptide AtlasQ9BXS4
HPRD12731
IPIIPI00550038   IPI00643279   IPI00513862   IPI00639913   IPI01010299   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXS4
IntAct (EBI)Q9BXS4
BioGRIDTMEM59
STRING (EMBL)TMEM59
ZODIACTMEM59
Ontologies - Pathways
QuickGOQ9BXS4
Ontology : AmiGOGolgi cis cisterna  Golgi trans cisterna  Golgi membrane  endopeptidase activity  protein binding  lysosome  lysosomal membrane  late endosome  Golgi medial cisterna  plasma membrane  proteolysis  autophagy  positive regulation of autophagy  negative regulation of protein processing  integral component of membrane  late endosome membrane  extracellular exosome  negative regulation of establishment of protein localization to plasma membrane  negative regulation of protein glycosylation in Golgi  
Ontology : EGO-EBIGolgi cis cisterna  Golgi trans cisterna  Golgi membrane  endopeptidase activity  protein binding  lysosome  lysosomal membrane  late endosome  Golgi medial cisterna  plasma membrane  proteolysis  autophagy  positive regulation of autophagy  negative regulation of protein processing  integral component of membrane  late endosome membrane  extracellular exosome  negative regulation of establishment of protein localization to plasma membrane  negative regulation of protein glycosylation in Golgi  
NDEx NetworkTMEM59
Atlas of Cancer Signalling NetworkTMEM59
Wikipedia pathwaysTMEM59
Orthology - Evolution
OrthoDB9528
Phylogenetic Trees/Animal Genes : TreeFamTMEM59
HOVERGENQ9BXS4
HOGENOMQ9BXS4
Homologs : HomoloGeneTMEM59
Homology/Alignments : Family Browser (UCSC)TMEM59
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM59 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM59
dbVarTMEM59
ClinVarTMEM59
1000_GenomesTMEM59 
Exome Variant ServerTMEM59
ExAC (Exome Aggregation Consortium)TMEM59 (select the gene name)
Genetic variants : HAPMAP9528
Genomic Variants (DGV)TMEM59 [DGVbeta]
DECIPHERTMEM59 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM59 
Mutations
ICGC Data PortalTMEM59 
TCGA Data PortalTMEM59 
Broad Tumor PortalTMEM59
OASIS PortalTMEM59 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM59  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM59
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM59
DgiDB (Drug Gene Interaction Database)TMEM59
DoCM (Curated mutations)TMEM59 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM59 (select a term)
intoGenTMEM59
Cancer3DTMEM59(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617084   
Orphanet
MedgenTMEM59
Genetic Testing Registry TMEM59
NextProtQ9BXS4 [Medical]
TSGene9528
GENETestsTMEM59
Target ValidationTMEM59
Huge Navigator TMEM59 [HugePedia]
snp3D : Map Gene to Disease9528
BioCentury BCIQTMEM59
ClinGenTMEM59
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9528
Chemical/Pharm GKB GenePA25620
Clinical trialTMEM59
Miscellaneous
canSAR (ICR)TMEM59 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM59
EVEXTMEM59
GoPubMedTMEM59
iHOPTMEM59
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:42:03 CEST 2017
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