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TMEM63B (transmembrane protein 63B)

Identity

Alias_namesC6orf110
chromosome 6 open reading frame 110
Alias_symbol (synonym)DKFZp434P0531
dJ421H19.2
Other alias
HGNC (Hugo) TMEM63B
LocusID (NCBI) 55362
Atlas_Id 74966
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44126914 and ends at 44155519 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC5L (6p21.1) / TMEM63B (6p21.1)TMEM63B (6p21.1) / MRPL14 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p21;p21) CDC5L/TMEM63B
t(6;6)(p21;p21) TMEM63B/MRPL14


External links

Nomenclature
HGNC (Hugo)TMEM63B   17735
Cards
Entrez_Gene (NCBI)TMEM63B  55362  transmembrane protein 63B
AliasesC6orf110
GeneCards (Weizmann)TMEM63B
Ensembl hg19 (Hinxton)ENSG00000137216 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137216 [Gene_View]  ENSG00000137216 [Sequence]  chr6:44126914-44155519 [Contig_View]  TMEM63B [Vega]
ICGC DataPortalENSG00000137216
TCGA cBioPortalTMEM63B
AceView (NCBI)TMEM63B
Genatlas (Paris)TMEM63B
WikiGenes55362
SOURCE (Princeton)TMEM63B
Genetics Home Reference (NIH)TMEM63B
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM63B  -     chr6:44126914-44155519 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM63B  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblTMEM63B - 6p21.1 [CytoView hg19]  TMEM63B - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBITMEM63B [Mapview hg19]  TMEM63B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK093629 AK309791 AL353957 AL834238 BC022095
RefSeq transcript (Entrez)NM_001318792 NM_018426
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM63B
Cluster EST : UnigeneHs.414473 [ NCBI ]
CGAP (NCI)Hs.414473
Alternative Splicing GalleryENSG00000137216
Gene ExpressionTMEM63B [ NCBI-GEO ]   TMEM63B [ EBI - ARRAY_EXPRESS ]   TMEM63B [ SEEK ]   TMEM63B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM63B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55362
GTEX Portal (Tissue expression)TMEM63B
Human Protein AtlasENSG00000137216-TMEM63B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T3F8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T3F8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T3F8
Splice isoforms : SwissVarQ5T3F8
PhosPhoSitePlusQ5T3F8
Domains : Interpro (EBI)Csc1_N    Nucleotide-bd_a/b_plait    PHM7_cyt    RSN1_7TM    TMEM63A/B   
Domain families : Pfam (Sanger)PHM7_cyt (PF14703)    RSN1_7TM (PF02714)    RSN1_TM (PF13967)   
Domain families : Pfam (NCBI)pfam14703    pfam02714    pfam13967   
Conserved Domain (NCBI)TMEM63B
DMDM Disease mutations55362
Blocks (Seattle)TMEM63B
SuperfamilyQ5T3F8
Human Protein Atlas [tissue]ENSG00000137216-TMEM63B [tissue]
Peptide AtlasQ5T3F8
HPRD16656
IPIIPI00514538   IPI00829680   IPI00829591   IPI00645632   IPI00977529   IPI00976875   
Protein Interaction databases
DIP (DOE-UCLA)Q5T3F8
IntAct (EBI)Q5T3F8
FunCoupENSG00000137216
BioGRIDTMEM63B
STRING (EMBL)TMEM63B
ZODIACTMEM63B
Ontologies - Pathways
QuickGOQ5T3F8
Ontology : AmiGOplasma membrane  ion transport  actin cytoskeleton  integral component of membrane  
Ontology : EGO-EBIplasma membrane  ion transport  actin cytoskeleton  integral component of membrane  
NDEx NetworkTMEM63B
Atlas of Cancer Signalling NetworkTMEM63B
Wikipedia pathwaysTMEM63B
Orthology - Evolution
OrthoDB55362
GeneTree (enSembl)ENSG00000137216
Phylogenetic Trees/Animal Genes : TreeFamTMEM63B
HOVERGENQ5T3F8
HOGENOMQ5T3F8
Homologs : HomoloGeneTMEM63B
Homology/Alignments : Family Browser (UCSC)TMEM63B
Gene fusions - Rearrangements
Fusion : QuiverTMEM63B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM63B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM63B
dbVarTMEM63B
ClinVarTMEM63B
1000_GenomesTMEM63B 
Exome Variant ServerTMEM63B
ExAC (Exome Aggregation Consortium)ENSG00000137216
GNOMAD BrowserENSG00000137216
Varsome BrowserTMEM63B
Genetic variants : HAPMAP55362
Genomic Variants (DGV)TMEM63B [DGVbeta]
DECIPHERTMEM63B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM63B 
Mutations
ICGC Data PortalTMEM63B 
TCGA Data PortalTMEM63B 
Broad Tumor PortalTMEM63B
OASIS PortalTMEM63B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM63B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM63B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM63B
DgiDB (Drug Gene Interaction Database)TMEM63B
DoCM (Curated mutations)TMEM63B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM63B (select a term)
intoGenTMEM63B
Cancer3DTMEM63B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTMEM63B
MedgenTMEM63B
Genetic Testing Registry TMEM63B
NextProtQ5T3F8 [Medical]
TSGene55362
GENETestsTMEM63B
Target ValidationTMEM63B
Huge Navigator TMEM63B [HugePedia]
snp3D : Map Gene to Disease55362
BioCentury BCIQTMEM63B
ClinGenTMEM63B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55362
Chemical/Pharm GKB GenePA134911221
Clinical trialTMEM63B
Miscellaneous
canSAR (ICR)TMEM63B (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM63B
EVEXTMEM63B
GoPubMedTMEM63B
iHOPTMEM63B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:35:52 CEST 2018

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