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TMEM74 (transmembrane protein 74)

Identity

Alias_symbol (synonym)FLJ30668
NET36
Other alias
HGNC (Hugo) TMEM74
LocusID (NCBI) 157753
Atlas_Id 47255
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 108778976 and ends at 108787615 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM74 (8q23.1) / CTSZ (20q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM74   26409
Cards
Entrez_Gene (NCBI)TMEM74  157753  transmembrane protein 74
AliasesNET36
GeneCards (Weizmann)TMEM74
Ensembl hg19 (Hinxton)ENSG00000164841 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164841 [Gene_View]  chr8:108778976-108787615 [Contig_View]  TMEM74 [Vega]
ICGC DataPortalENSG00000164841
TCGA cBioPortalTMEM74
AceView (NCBI)TMEM74
Genatlas (Paris)TMEM74
WikiGenes157753
SOURCE (Princeton)TMEM74
Genetics Home Reference (NIH)TMEM74
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM74  -     chr8:108778976-108787615 -  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM74  -     8q23.1   [Description]    (hg19-Feb_2009)
EnsemblTMEM74 - 8q23.1 [CytoView hg19]  TMEM74 - 8q23.1 [CytoView hg38]
Mapping of homologs : NCBITMEM74 [Mapview hg19]  TMEM74 [Mapview hg38]
OMIM613935   
Gene and transcription
Genbank (Entrez)AK055230 BC030710 BC033057 D60265 HQ447393
RefSeq transcript (Entrez)NM_153015
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM74
Cluster EST : UnigeneHs.99439 [ NCBI ]
CGAP (NCI)Hs.99439
Alternative Splicing GalleryENSG00000164841
Gene ExpressionTMEM74 [ NCBI-GEO ]   TMEM74 [ EBI - ARRAY_EXPRESS ]   TMEM74 [ SEEK ]   TMEM74 [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM74 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)157753
GTEX Portal (Tissue expression)TMEM74
Human Protein AtlasENSG00000164841-TMEM74 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NL1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NL1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NL1
Splice isoforms : SwissVarQ96NL1
PhosPhoSitePlusQ96NL1
Domains : Interpro (EBI)Tmem74    TMEM74-like   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TMEM74
DMDM Disease mutations157753
Blocks (Seattle)TMEM74
SuperfamilyQ96NL1
Human Protein Atlas [tissue]ENSG00000164841-TMEM74 [tissue]
Peptide AtlasQ96NL1
HPRD08702
IPIIPI00043733   
Protein Interaction databases
DIP (DOE-UCLA)Q96NL1
IntAct (EBI)Q96NL1
FunCoupENSG00000164841
BioGRIDTMEM74
STRING (EMBL)TMEM74
ZODIACTMEM74
Ontologies - Pathways
QuickGOQ96NL1
Ontology : AmiGOautophagosome membrane  protein binding  lysosome  lysosomal membrane  integral component of membrane  macroautophagy  cytoplasmic vesicle  
Ontology : EGO-EBIautophagosome membrane  protein binding  lysosome  lysosomal membrane  integral component of membrane  macroautophagy  cytoplasmic vesicle  
NDEx NetworkTMEM74
Atlas of Cancer Signalling NetworkTMEM74
Wikipedia pathwaysTMEM74
Orthology - Evolution
OrthoDB157753
GeneTree (enSembl)ENSG00000164841
Phylogenetic Trees/Animal Genes : TreeFamTMEM74
HOVERGENQ96NL1
HOGENOMQ96NL1
Homologs : HomoloGeneTMEM74
Homology/Alignments : Family Browser (UCSC)TMEM74
Gene fusions - Rearrangements
Tumor Fusion PortalTMEM74
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM74
dbVarTMEM74
ClinVarTMEM74
1000_GenomesTMEM74 
Exome Variant ServerTMEM74
ExAC (Exome Aggregation Consortium)ENSG00000164841
GNOMAD BrowserENSG00000164841
Genetic variants : HAPMAP157753
Genomic Variants (DGV)TMEM74 [DGVbeta]
DECIPHERTMEM74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM74 
Mutations
ICGC Data PortalTMEM74 
TCGA Data PortalTMEM74 
Broad Tumor PortalTMEM74
OASIS PortalTMEM74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM74  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM74
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM74
DgiDB (Drug Gene Interaction Database)TMEM74
DoCM (Curated mutations)TMEM74 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM74 (select a term)
intoGenTMEM74
Cancer3DTMEM74(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613935   
Orphanet
DisGeNETTMEM74
MedgenTMEM74
Genetic Testing Registry TMEM74
NextProtQ96NL1 [Medical]
TSGene157753
GENETestsTMEM74
Target ValidationTMEM74
Huge Navigator TMEM74 [HugePedia]
snp3D : Map Gene to Disease157753
BioCentury BCIQTMEM74
ClinGenTMEM74
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD157753
Chemical/Pharm GKB GenePA142670785
Clinical trialTMEM74
Miscellaneous
canSAR (ICR)TMEM74 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM74
EVEXTMEM74
GoPubMedTMEM74
iHOPTMEM74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:38:53 CET 2017

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