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TMEM8A (transmembrane protein 8A)

Identity

Alias_namesTMEM6
TMEM8
transmembrane protein 6
transmembrane protein 8 (five membrane-spanning domains)
Alias_symbol (synonym)M83
Other alias
HGNC (Hugo) TMEM8A
LocusID (NCBI) 58986
Atlas_Id 74989
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 370776 and ends at 381950 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGRN (1p36.33) / TMEM8A (16p13.3)BSG (19p13.3) / TMEM8A (16p13.3)TMEM8A (16p13.3) / GPX4 (19p13.3)
TMEM8A (16p13.3) / YBX3 (12p13.2)YBX3 (12p13.2) / TMEM8A (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM8A   17205
Cards
Entrez_Gene (NCBI)TMEM8A  58986  transmembrane protein 8A
AliasesM83; TMEM6; TMEM8
GeneCards (Weizmann)TMEM8A
Ensembl hg19 (Hinxton)ENSG00000129925 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129925 [Gene_View]  chr16:370776-381950 [Contig_View]  TMEM8A [Vega]
ICGC DataPortalENSG00000129925
TCGA cBioPortalTMEM8A
AceView (NCBI)TMEM8A
Genatlas (Paris)TMEM8A
WikiGenes58986
SOURCE (Princeton)TMEM8A
Genetics Home Reference (NIH)TMEM8A
Genomic and cartography
GoldenPath hg38 (UCSC)TMEM8A  -     chr16:370776-381950 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMEM8A  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblTMEM8A - 16p13.3 [CytoView hg19]  TMEM8A - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBITMEM8A [Mapview hg19]  TMEM8A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB045292 AI678371 AK024725 AK091823 AL537021
RefSeq transcript (Entrez)NM_021259
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMEM8A
Cluster EST : UnigeneHs.288940 [ NCBI ]
CGAP (NCI)Hs.288940
Alternative Splicing GalleryENSG00000129925
Gene ExpressionTMEM8A [ NCBI-GEO ]   TMEM8A [ EBI - ARRAY_EXPRESS ]   TMEM8A [ SEEK ]   TMEM8A [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58986
GTEX Portal (Tissue expression)TMEM8A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCN3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCN3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCN3
Splice isoforms : SwissVarQ9HCN3
PhosPhoSitePlusQ9HCN3
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)DUF3522    EGF-like_CS    EGF-like_dom   
Domain families : Pfam (Sanger)DUF3522 (PF12036)   
Domain families : Pfam (NCBI)pfam12036   
Conserved Domain (NCBI)TMEM8A
DMDM Disease mutations58986
Blocks (Seattle)TMEM8A
SuperfamilyQ9HCN3
Human Protein AtlasENSG00000129925
Peptide AtlasQ9HCN3
HPRD11636
IPIIPI00289131   IPI00607788   IPI00893985   IPI00925591   IPI00925350   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCN3
IntAct (EBI)Q9HCN3
FunCoupENSG00000129925
BioGRIDTMEM8A
STRING (EMBL)TMEM8A
ZODIACTMEM8A
Ontologies - Pathways
QuickGOQ9HCN3
Ontology : AmiGOmolecular_function  protein binding  lysosomal membrane  plasma membrane  integral component of plasma membrane  cell adhesion  biological_process  extracellular exosome  
Ontology : EGO-EBImolecular_function  protein binding  lysosomal membrane  plasma membrane  integral component of plasma membrane  cell adhesion  biological_process  extracellular exosome  
NDEx NetworkTMEM8A
Atlas of Cancer Signalling NetworkTMEM8A
Wikipedia pathwaysTMEM8A
Orthology - Evolution
OrthoDB58986
GeneTree (enSembl)ENSG00000129925
Phylogenetic Trees/Animal Genes : TreeFamTMEM8A
HOVERGENQ9HCN3
HOGENOMQ9HCN3
Homologs : HomoloGeneTMEM8A
Homology/Alignments : Family Browser (UCSC)TMEM8A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM8A
dbVarTMEM8A
ClinVarTMEM8A
1000_GenomesTMEM8A 
Exome Variant ServerTMEM8A
ExAC (Exome Aggregation Consortium)TMEM8A (select the gene name)
Genetic variants : HAPMAP58986
Genomic Variants (DGV)TMEM8A [DGVbeta]
DECIPHERTMEM8A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMEM8A 
Mutations
ICGC Data PortalTMEM8A 
TCGA Data PortalTMEM8A 
Broad Tumor PortalTMEM8A
OASIS PortalTMEM8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM8A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM8A
DgiDB (Drug Gene Interaction Database)TMEM8A
DoCM (Curated mutations)TMEM8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM8A (select a term)
intoGenTMEM8A
Cancer3DTMEM8A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMEM8A
Genetic Testing Registry TMEM8A
NextProtQ9HCN3 [Medical]
TSGene58986
GENETestsTMEM8A
Target ValidationTMEM8A
Huge Navigator TMEM8A [HugePedia]
snp3D : Map Gene to Disease58986
BioCentury BCIQTMEM8A
ClinGenTMEM8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58986
Chemical/Pharm GKB GenePA38211
Clinical trialTMEM8A
Miscellaneous
canSAR (ICR)TMEM8A (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM8A
EVEXTMEM8A
GoPubMedTMEM8A
iHOPTMEM8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:46:31 CEST 2017

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