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TMEM8B (transmembrane protein 8B)

Identity

Alias_namesC9orf127
chromosome 9 open reading frame 127
Alias_symbol (synonym)NAG-5
NGX6
Other aliasNAG5
HGNC (Hugo) TMEM8B
LocusID (NCBI) 51754
Atlas_Id 50966
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35829222 and ends at 35854844 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MTUS2 (13q12.3) / TMEM8B (9p13.3)NFX1 (9p13.3) / TMEM8B (9p13.3)RECK (9p13.3) / TMEM8B (9p13.3)
TMEM8B (9p13.3) / TLN1 (9p13.3)NFX1 9p13.3 / TMEM8B 9p13.3RECK 9p13.3 / TMEM8B 9p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMEM8B   21427
Cards
Entrez_Gene (NCBI)TMEM8B  51754  transmembrane protein 8B
AliasesC9orf127; NAG-5; NAG5; NGX6
GeneCards (Weizmann)TMEM8B
Ensembl hg19 (Hinxton)ENSG00000137103 [Gene_View]  chr9:35829222-35854844 [Contig_View]  TMEM8B [Vega]
Ensembl hg38 (Hinxton)ENSG00000137103 [Gene_View]  chr9:35829222-35854844 [Contig_View]  TMEM8B [Vega]
ICGC DataPortalENSG00000137103
TCGA cBioPortalTMEM8B
AceView (NCBI)TMEM8B
Genatlas (Paris)TMEM8B
WikiGenes51754
SOURCE (Princeton)TMEM8B
Genetics Home Reference (NIH)TMEM8B
Genomic and cartography
GoldenPath hg19 (UCSC)TMEM8B  -     chr9:35829222-35854844 +  9p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMEM8B  -     9p13.3   [Description]    (hg38-Dec_2013)
EnsemblTMEM8B - 9p13.3 [CytoView hg19]  TMEM8B - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBITMEM8B [Mapview hg19]  TMEM8B [Mapview hg38]
OMIM616888   
Gene and transcription
Genbank (Entrez)AF070572 AF188239 AK074844 BC041377 BC043384
RefSeq transcript (Entrez)NM_001042589 NM_001042590 NM_016446
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)TMEM8B
Cluster EST : UnigeneHs.493808 [ NCBI ]
CGAP (NCI)Hs.493808
Alternative Splicing GalleryENSG00000137103
Gene ExpressionTMEM8B [ NCBI-GEO ]   TMEM8B [ EBI - ARRAY_EXPRESS ]   TMEM8B [ SEEK ]   TMEM8B [ MEM ]
Gene Expression Viewer (FireBrowse)TMEM8B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51754
GTEX Portal (Tissue expression)TMEM8B
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NDV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NDV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NDV4
Splice isoforms : SwissVarA6NDV4
PhosPhoSitePlusA6NDV4
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)   
Domains : Interpro (EBI)DUF3522    EGF-like_CS    EGF-like_dom   
Domain families : Pfam (Sanger)DUF3522 (PF12036)   
Domain families : Pfam (NCBI)pfam12036   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)TMEM8B
DMDM Disease mutations51754
Blocks (Seattle)TMEM8B
SuperfamilyA6NDV4
Human Protein AtlasENSG00000137103
Peptide AtlasA6NDV4
HPRD16674
IPIIPI00513780   IPI00415061   IPI00894263   
Protein Interaction databases
DIP (DOE-UCLA)A6NDV4
IntAct (EBI)A6NDV4
FunCoupENSG00000137103
BioGRIDTMEM8B
STRING (EMBL)TMEM8B
ZODIACTMEM8B
Ontologies - Pathways
QuickGOA6NDV4
Ontology : AmiGOprotein binding  nucleus  mitochondrion  endoplasmic reticulum  plasma membrane  cell-matrix adhesion  regulation of mitotic cell cycle  cell surface  integral component of membrane  regulation of growth  
Ontology : EGO-EBIprotein binding  nucleus  mitochondrion  endoplasmic reticulum  plasma membrane  cell-matrix adhesion  regulation of mitotic cell cycle  cell surface  integral component of membrane  regulation of growth  
NDEx NetworkTMEM8B
Atlas of Cancer Signalling NetworkTMEM8B
Wikipedia pathwaysTMEM8B
Orthology - Evolution
OrthoDB51754
GeneTree (enSembl)ENSG00000137103
Phylogenetic Trees/Animal Genes : TreeFamTMEM8B
HOVERGENA6NDV4
HOGENOMA6NDV4
Homologs : HomoloGeneTMEM8B
Homology/Alignments : Family Browser (UCSC)TMEM8B
Gene fusions - Rearrangements
Fusion : MitelmanNFX1/TMEM8B [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanRECK/TMEM8B [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanTMEM8B/TLN1 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion: TCGANFX1 9p13.3 TMEM8B 9p13.3 LUSC
Fusion: TCGARECK 9p13.3 TMEM8B 9p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMEM8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMEM8B
dbVarTMEM8B
ClinVarTMEM8B
1000_GenomesTMEM8B 
Exome Variant ServerTMEM8B
ExAC (Exome Aggregation Consortium)TMEM8B (select the gene name)
Genetic variants : HAPMAP51754
Genomic Variants (DGV)TMEM8B [DGVbeta]
DECIPHER (Syndromes)9:35829222-35854844  ENSG00000137103
CONAN: Copy Number AnalysisTMEM8B 
Mutations
ICGC Data PortalTMEM8B 
TCGA Data PortalTMEM8B 
Broad Tumor PortalTMEM8B
OASIS PortalTMEM8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMEM8B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMEM8B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMEM8B
DgiDB (Drug Gene Interaction Database)TMEM8B
DoCM (Curated mutations)TMEM8B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMEM8B (select a term)
intoGenTMEM8B
Cancer3DTMEM8B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616888   
Orphanet
MedgenTMEM8B
Genetic Testing Registry TMEM8B
NextProtA6NDV4 [Medical]
TSGene51754
GENETestsTMEM8B
Huge Navigator TMEM8B [HugePedia]
snp3D : Map Gene to Disease51754
BioCentury BCIQTMEM8B
ClinGenTMEM8B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51754
Chemical/Pharm GKB GenePA165586305
Clinical trialTMEM8B
Miscellaneous
canSAR (ICR)TMEM8B (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMEM8B
EVEXTMEM8B
GoPubMedTMEM8B
iHOPTMEM8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:31:32 CET 2017

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