TMPO (thymopoietin)

2007-02-01 Affiliation

Identity

HGNC

TMPO

LOCATION

12q23.1

LOCUSID

7112

ALIAS

CMD1T,LAP2,LEMD4,PRO0868,TP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7112
MIM: 188380
HGNC: 11875
Ensembl: ENSG00000120802

Variants:

dbSNP: 7112
ClinVar: 7112
TCGA: ENSG00000120802
COSMIC: TMPO

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120802	ENST00000261210	P42167
ENSG00000120802	ENST00000266732	P42166
ENSG00000120802	ENST00000343315	G5E972
ENSG00000120802	ENST00000393053	P42167
ENSG00000120802	ENST00000393053	A0A024RBH7
ENSG00000120802	ENST00000556029	P42167
ENSG00000120802	ENST00000556029	A0A024RBE7
ENSG00000120802	ENST00000556678	H0YJH7

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Clearance of Nuclear Envelope Membranes from Chromatin	REACTOME	R-HSA-2993913
Depolymerisation of the Nuclear Lamina	REACTOME	R-HSA-4419969
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Nuclear Envelope Reassembly	REACTOME	R-HSA-2995410
Initiation of Nuclear Envelope Reformation	REACTOME	R-HSA-2995383

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15546916	2004	LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.	77
12475961	2002	Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein.	76
16247757	2005	Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy.	56
16606692	2006	Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway.	56
17227891	2007	Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts.	49
26312502	2015	Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.	37
26443848	2015	Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.	29
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
19929986	2009	Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes.	21

Citation

Dessen P

TMPO (thymopoietin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45593/tmpo