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TMPRSS11B (transmembrane protease, serine 11B)

Identity

Other alias-
HGNC (Hugo) TMPRSS11B
LocusID (NCBI) 132724
Atlas_Id 75007
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 68226653 and ends at 68245694 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TMPRSS11B (4q13.2) / LCLAT1 (2p23.1)TMPRSS11B (4q13.2) / TSN (2q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMPRSS11B   25398
Cards
Entrez_Gene (NCBI)TMPRSS11B  132724  transmembrane protease, serine 11B
Aliases
GeneCards (Weizmann)TMPRSS11B
Ensembl hg19 (Hinxton)ENSG00000185873 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185873 [Gene_View]  chr4:68226653-68245694 [Contig_View]  TMPRSS11B [Vega]
ICGC DataPortalENSG00000185873
TCGA cBioPortalTMPRSS11B
AceView (NCBI)TMPRSS11B
Genatlas (Paris)TMPRSS11B
WikiGenes132724
SOURCE (Princeton)TMPRSS11B
Genetics Home Reference (NIH)TMPRSS11B
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS11B  -     chr4:68226653-68245694 -  4q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS11B  -     4q13.2   [Description]    (hg19-Feb_2009)
EnsemblTMPRSS11B - 4q13.2 [CytoView hg19]  TMPRSS11B - 4q13.2 [CytoView hg38]
Mapping of homologs : NCBITMPRSS11B [Mapview hg19]  TMPRSS11B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK290904 AK310210 AL833167 AM393733 BC126195
RefSeq transcript (Entrez)NM_182502
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMPRSS11B
Cluster EST : UnigeneHs.407122 [ NCBI ]
CGAP (NCI)Hs.407122
Alternative Splicing GalleryENSG00000185873
Gene ExpressionTMPRSS11B [ NCBI-GEO ]   TMPRSS11B [ EBI - ARRAY_EXPRESS ]   TMPRSS11B [ SEEK ]   TMPRSS11B [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS11B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)132724
GTEX Portal (Tissue expression)TMPRSS11B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86T26   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86T26  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86T26
Splice isoforms : SwissVarQ86T26
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ86T26
Domaine pattern : Prosite (Expaxy)SEA (PS50024)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)   
Domains : Interpro (EBI)Pept_S1A_HAT/DESC1    Peptidase_S1_PA    Peptidase_S1A    SEA_dom    Trypsin_dom    TRYPSIN_HIS   
Domain families : Pfam (Sanger)SEA (PF01390)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam01390    pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS11B
DMDM Disease mutations132724
Blocks (Seattle)TMPRSS11B
SuperfamilyQ86T26
Human Protein AtlasENSG00000185873
Peptide AtlasQ86T26
HPRD13219
IPIIPI00328460   
Protein Interaction databases
DIP (DOE-UCLA)Q86T26
IntAct (EBI)Q86T26
FunCoupENSG00000185873
BioGRIDTMPRSS11B
STRING (EMBL)TMPRSS11B
ZODIACTMPRSS11B
Ontologies - Pathways
QuickGOQ86T26
Ontology : AmiGOserine-type endopeptidase activity  plasma membrane  integral component of plasma membrane  proteolysis  biological_process  serine-type peptidase activity  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase activity  plasma membrane  integral component of plasma membrane  proteolysis  biological_process  serine-type peptidase activity  extracellular exosome  
NDEx NetworkTMPRSS11B
Atlas of Cancer Signalling NetworkTMPRSS11B
Wikipedia pathwaysTMPRSS11B
Orthology - Evolution
OrthoDB132724
GeneTree (enSembl)ENSG00000185873
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS11B
HOVERGENQ86T26
HOGENOMQ86T26
Homologs : HomoloGeneTMPRSS11B
Homology/Alignments : Family Browser (UCSC)TMPRSS11B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS11B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS11B
dbVarTMPRSS11B
ClinVarTMPRSS11B
1000_GenomesTMPRSS11B 
Exome Variant ServerTMPRSS11B
ExAC (Exome Aggregation Consortium)TMPRSS11B (select the gene name)
Genetic variants : HAPMAP132724
Genomic Variants (DGV)TMPRSS11B [DGVbeta]
DECIPHERTMPRSS11B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS11B 
Mutations
ICGC Data PortalTMPRSS11B 
TCGA Data PortalTMPRSS11B 
Broad Tumor PortalTMPRSS11B
OASIS PortalTMPRSS11B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS11B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMPRSS11B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMPRSS11B
DgiDB (Drug Gene Interaction Database)TMPRSS11B
DoCM (Curated mutations)TMPRSS11B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS11B (select a term)
intoGenTMPRSS11B
Cancer3DTMPRSS11B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMPRSS11B
Genetic Testing Registry TMPRSS11B
NextProtQ86T26 [Medical]
TSGene132724
GENETestsTMPRSS11B
Target ValidationTMPRSS11B
Huge Navigator TMPRSS11B [HugePedia]
snp3D : Map Gene to Disease132724
BioCentury BCIQTMPRSS11B
ClinGenTMPRSS11B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD132724
Chemical/Pharm GKB GenePA142670727
Clinical trialTMPRSS11B
Miscellaneous
canSAR (ICR)TMPRSS11B (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMPRSS11B
EVEXTMPRSS11B
GoPubMedTMPRSS11B
iHOPTMPRSS11B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:46:35 CEST 2017

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