Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TMPRSS11E (transmembrane serine protease 11E)

Identity

Alias (NCBI)DESC1
TMPRSS11E2
HGNC (Hugo) TMPRSS11E
HGNC Alias symbDESC1
HGNC Previous nameTMPRSS11E2
HGNC Previous nametransmembrane protease, serine 11E2
 transmembrane protease, serine 11E
LocusID (NCBI) 28983
Atlas_Id 55905
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 68447463 and ends at 68497604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLC4A4 (4q13.3) / TMPRSS11E (4q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SLC4A4/TMPRSS11E (4q13)


External links

Nomenclature
HGNC (Hugo)TMPRSS11E   24465
Cards
Entrez_Gene (NCBI)TMPRSS11E  28983  transmembrane serine protease 11E
AliasesDESC1; TMPRSS11E2
GeneCards (Weizmann)TMPRSS11E
Ensembl hg19 (Hinxton)ENSG00000087128 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087128 [Gene_View]  ENSG00000087128 [Sequence]  chr4:68447463-68497604 [Contig_View]  TMPRSS11E [Vega]
ICGC DataPortalENSG00000087128
TCGA cBioPortalTMPRSS11E
AceView (NCBI)TMPRSS11E
Genatlas (Paris)TMPRSS11E
WikiGenes28983
SOURCE (Princeton)TMPRSS11E
Genetics Home Reference (NIH)TMPRSS11E
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS11E  -     chr4:68447463-68497604 +  4q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS11E  -     4q13.2   [Description]    (hg19-Feb_2009)
GoldenPathTMPRSS11E - 4q13.2 [CytoView hg19]  TMPRSS11E - 4q13.2 [CytoView hg38]
ImmunoBaseENSG00000087128
genome Data Viewer NCBITMPRSS11E [Mapview hg19]  
OMIM610399   
Gene and transcription
Genbank (Entrez)AF064819 AK292787 AK313859 AY359017 BC113412
RefSeq transcript (Entrez)NM_014058
RefSeq genomic (Entrez)NC_000004 NT_167250
Consensus coding sequences : CCDS (NCBI)TMPRSS11E
Alternative Splicing GalleryENSG00000087128
Gene ExpressionTMPRSS11E [ NCBI-GEO ]   TMPRSS11E [ EBI - ARRAY_EXPRESS ]   TMPRSS11E [ SEEK ]   TMPRSS11E [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS11E [ Firebrowse - Broad ]
GenevisibleExpression of TMPRSS11E in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28983
GTEX Portal (Tissue expression)TMPRSS11E
Human Protein AtlasENSG00000087128-TMPRSS11E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL52   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL52  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL52
Splice isoforms : SwissVarQ9UL52
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UL52
Domaine pattern : Prosite (Expaxy)SEA (PS50024)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Pept_S1A_HAT/DESC1    Peptidase_S1_PA    Peptidase_S1A    SEA_dom    SEA_dom_sf    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)SEA (PF01390)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam01390    pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS11E
DMDM Disease mutations28983
Blocks (Seattle)TMPRSS11E
PDB (RSDB)2OQ5   
PDB Europe2OQ5   
PDB (PDBSum)2OQ5   
PDB (IMB)2OQ5   
Structural Biology KnowledgeBase2OQ5   
SCOP (Structural Classification of Proteins)2OQ5   
CATH (Classification of proteins structures)2OQ5   
SuperfamilyQ9UL52
Human Protein Atlas [tissue]ENSG00000087128-TMPRSS11E [tissue]
Peptide AtlasQ9UL52
HPRD09912
IPIIPI00297030   IPI00964712   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL52
IntAct (EBI)Q9UL52
FunCoupENSG00000087128
BioGRIDTMPRSS11E
STRING (EMBL)TMPRSS11E
ZODIACTMPRSS11E
Ontologies - Pathways
QuickGOQ9UL52
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  plasma membrane  integral component of plasma membrane  proteolysis  serine-type peptidase activity  cognition  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  plasma membrane  integral component of plasma membrane  proteolysis  serine-type peptidase activity  cognition  
NDEx NetworkTMPRSS11E
Atlas of Cancer Signalling NetworkTMPRSS11E
Wikipedia pathwaysTMPRSS11E
Orthology - Evolution
OrthoDB28983
GeneTree (enSembl)ENSG00000087128
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS11E
HOGENOMQ9UL52
Homologs : HomoloGeneTMPRSS11E
Homology/Alignments : Family Browser (UCSC)TMPRSS11E
Gene fusions - Rearrangements
Fusion : QuiverTMPRSS11E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS11E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS11E
dbVarTMPRSS11E
ClinVarTMPRSS11E
MonarchTMPRSS11E
1000_GenomesTMPRSS11E 
Exome Variant ServerTMPRSS11E
GNOMAD BrowserENSG00000087128
Varsome BrowserTMPRSS11E
Genetic variants : HAPMAP28983
Genomic Variants (DGV)TMPRSS11E [DGVbeta]
DECIPHERTMPRSS11E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS11E 
Mutations
ICGC Data PortalTMPRSS11E 
TCGA Data PortalTMPRSS11E 
Broad Tumor PortalTMPRSS11E
OASIS PortalTMPRSS11E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS11E  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMPRSS11E
Mutations and Diseases : HGMDTMPRSS11E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMPRSS11E
DgiDB (Drug Gene Interaction Database)TMPRSS11E
DoCM (Curated mutations)TMPRSS11E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS11E (select a term)
intoGenTMPRSS11E
Cancer3DTMPRSS11E(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610399   
Orphanet
DisGeNETTMPRSS11E
MedgenTMPRSS11E
Genetic Testing Registry TMPRSS11E
NextProtQ9UL52 [Medical]
TSGene28983
GENETestsTMPRSS11E
Target ValidationTMPRSS11E
Huge Navigator TMPRSS11E [HugePedia]
snp3D : Map Gene to Disease28983
BioCentury BCIQTMPRSS11E
ClinGenTMPRSS11E
Clinical trials, drugs, therapy
Protein Interactions : CTD28983
Pharm GKB GenePA142670729
Clinical trialTMPRSS11E
Miscellaneous
canSAR (ICR)TMPRSS11E (select the gene name)
HarmonizomeTMPRSS11E
DataMed IndexTMPRSS11E
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMPRSS11E
EVEXTMPRSS11E
GoPubMedTMPRSS11E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:36:33 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.