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TMPRSS12 (transmembrane protease, serine 12)

Identity

Alias_namestransmembrane protease, serine 12
transmembrane (C-terminal) protease, serine 12
Alias_symbol (synonym)MGC57341
CT151
Other alias
HGNC (Hugo) TMPRSS12
LocusID (NCBI) 283471
Atlas_Id 75013
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 50842918 and ends at 50887880 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMPRSS12 (12q13.12) / KIF27 (9q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMPRSS12   28779
Cards
Entrez_Gene (NCBI)TMPRSS12  283471  transmembrane protease, serine 12
AliasesCT151
GeneCards (Weizmann)TMPRSS12
Ensembl hg19 (Hinxton)ENSG00000186452 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186452 [Gene_View]  chr12:50842918-50887880 [Contig_View]  TMPRSS12 [Vega]
ICGC DataPortalENSG00000186452
TCGA cBioPortalTMPRSS12
AceView (NCBI)TMPRSS12
Genatlas (Paris)TMPRSS12
WikiGenes283471
SOURCE (Princeton)TMPRSS12
Genetics Home Reference (NIH)TMPRSS12
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS12  -     chr12:50842918-50887880 +  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS12  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblTMPRSS12 - 12q13.12 [CytoView hg19]  TMPRSS12 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBITMPRSS12 [Mapview hg19]  TMPRSS12 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA884376 BC035123 BC048112 DB458497 HM005521
RefSeq transcript (Entrez)NM_182559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMPRSS12
Cluster EST : UnigeneHs.125571 [ NCBI ]
CGAP (NCI)Hs.125571
Alternative Splicing GalleryENSG00000186452
Gene ExpressionTMPRSS12 [ NCBI-GEO ]   TMPRSS12 [ EBI - ARRAY_EXPRESS ]   TMPRSS12 [ SEEK ]   TMPRSS12 [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283471
GTEX Portal (Tissue expression)TMPRSS12
Human Protein AtlasENSG00000186452-TMPRSS12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WS5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WS5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WS5
Splice isoforms : SwissVarQ86WS5
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ86WS5
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS12
DMDM Disease mutations283471
Blocks (Seattle)TMPRSS12
SuperfamilyQ86WS5
Human Protein Atlas [tissue]ENSG00000186452-TMPRSS12 [tissue]
Peptide AtlasQ86WS5
HPRD07133
IPIIPI00385595   IPI01022083   
Protein Interaction databases
DIP (DOE-UCLA)Q86WS5
IntAct (EBI)Q86WS5
FunCoupENSG00000186452
BioGRIDTMPRSS12
STRING (EMBL)TMPRSS12
ZODIACTMPRSS12
Ontologies - Pathways
QuickGOQ86WS5
Ontology : AmiGOserine-type endopeptidase activity  proteolysis  integral component of membrane  
Ontology : EGO-EBIserine-type endopeptidase activity  proteolysis  integral component of membrane  
NDEx NetworkTMPRSS12
Atlas of Cancer Signalling NetworkTMPRSS12
Wikipedia pathwaysTMPRSS12
Orthology - Evolution
OrthoDB283471
GeneTree (enSembl)ENSG00000186452
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS12
HOVERGENQ86WS5
HOGENOMQ86WS5
Homologs : HomoloGeneTMPRSS12
Homology/Alignments : Family Browser (UCSC)TMPRSS12
Gene fusions - Rearrangements
Fusion: Tumor Portal TMPRSS12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS12
dbVarTMPRSS12
ClinVarTMPRSS12
1000_GenomesTMPRSS12 
Exome Variant ServerTMPRSS12
ExAC (Exome Aggregation Consortium)ENSG00000186452
GNOMAD BrowserENSG00000186452
Genetic variants : HAPMAP283471
Genomic Variants (DGV)TMPRSS12 [DGVbeta]
DECIPHERTMPRSS12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS12 
Mutations
ICGC Data PortalTMPRSS12 
TCGA Data PortalTMPRSS12 
Broad Tumor PortalTMPRSS12
OASIS PortalTMPRSS12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMPRSS12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMPRSS12
DgiDB (Drug Gene Interaction Database)TMPRSS12
DoCM (Curated mutations)TMPRSS12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS12 (select a term)
intoGenTMPRSS12
Cancer3DTMPRSS12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMPRSS12
Genetic Testing Registry TMPRSS12
NextProtQ86WS5 [Medical]
TSGene283471
GENETestsTMPRSS12
Target ValidationTMPRSS12
Huge Navigator TMPRSS12 [HugePedia]
snp3D : Map Gene to Disease283471
BioCentury BCIQTMPRSS12
ClinGenTMPRSS12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283471
Chemical/Pharm GKB GenePA142670731
Clinical trialTMPRSS12
Miscellaneous
canSAR (ICR)TMPRSS12 (select the gene name)
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMPRSS12
EVEXTMPRSS12
GoPubMedTMPRSS12
iHOPTMPRSS12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:33:26 CET 2017

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