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TMPRSS15 (transmembrane protease, serine 15)

Identity

Alias_namesPRSS7
protease
Alias_symbol (synonym)ENTK
MGC133046
Other alias
HGNC (Hugo) TMPRSS15
LocusID (NCBI) 5651
Atlas_Id 51488
Location 21q21.1  [Link to chromosome band 21q21]
Location_base_pair Starts at 18269116 and ends at 18403653 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANK3 (10q21.2) / TMPRSS15 (21q21.1)POU1F1 (3p11.2) / TMPRSS15 (21q21.1)ANK3 10q21.2 / TMPRSS15 21q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TMPRSS15   9490
Cards
Entrez_Gene (NCBI)TMPRSS15  5651  transmembrane protease, serine 15
AliasesENTK; PRSS7
GeneCards (Weizmann)TMPRSS15
Ensembl hg19 (Hinxton)ENSG00000154646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154646 [Gene_View]  chr21:18269116-18403653 [Contig_View]  TMPRSS15 [Vega]
ICGC DataPortalENSG00000154646
TCGA cBioPortalTMPRSS15
AceView (NCBI)TMPRSS15
Genatlas (Paris)TMPRSS15
WikiGenes5651
SOURCE (Princeton)TMPRSS15
Genetics Home Reference (NIH)TMPRSS15
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS15  -     chr21:18269116-18403653 -  21q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS15  -     21q21.1   [Description]    (hg19-Feb_2009)
EnsemblTMPRSS15 - 21q21.1 [CytoView hg19]  TMPRSS15 - 21q21.1 [CytoView hg38]
Mapping of homologs : NCBITMPRSS15 [Mapview hg19]  TMPRSS15 [Mapview hg38]
OMIM226200   606635   
Gene and transcription
Genbank (Entrez)AI279666 BC111749 BM015908 DB242953 KF688184
RefSeq transcript (Entrez)NM_002772
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMPRSS15
Cluster EST : UnigeneHs.149473 [ NCBI ]
CGAP (NCI)Hs.149473
Alternative Splicing GalleryENSG00000154646
Gene ExpressionTMPRSS15 [ NCBI-GEO ]   TMPRSS15 [ EBI - ARRAY_EXPRESS ]   TMPRSS15 [ SEEK ]   TMPRSS15 [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5651
GTEX Portal (Tissue expression)TMPRSS15
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98073   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP98073  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP98073
Splice isoforms : SwissVarP98073
Catalytic activity : Enzyme3.4.21.9 [ Enzyme-Expasy ]   3.4.21.93.4.21.9 [ IntEnz-EBI ]   3.4.21.9 [ BRENDA ]   3.4.21.9 [ KEGG ]   
PhosPhoSitePlusP98073
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    MAM_1 (PS00740)    MAM_2 (PS50060)    SEA (PS50024)    SRCR_2 (PS50287)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)ConA-like_dom    CUB_dom    LDLR_class-A_CS    LDrepeatLR_classA_rpt    MAM_dom    Pept_S1A_enterop    Peptidase_S1_PA    Peptidase_S1A    SEA_dom    SRCR    SRCR-like_dom    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)CUB (PF00431)    Ldl_recept_a (PF00057)    MAM (PF00629)    SEA (PF01390)    SRCR_2 (PF15494)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00431    pfam00057    pfam00629    pfam01390    pfam15494    pfam00089   
Domain families : Smart (EMBL)CUB (SM00042)  LDLa (SM00192)  MAM (SM00137)  SEA (SM00200)  SR (SM00202)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS15
DMDM Disease mutations5651
Blocks (Seattle)TMPRSS15
PDB (SRS)4DGJ   
PDB (PDBSum)4DGJ   
PDB (IMB)4DGJ   
PDB (RSDB)4DGJ   
Structural Biology KnowledgeBase4DGJ   
SCOP (Structural Classification of Proteins)4DGJ   
CATH (Classification of proteins structures)4DGJ   
SuperfamilyP98073
Human Protein AtlasENSG00000154646
Peptide AtlasP98073
HPRD05972
IPIIPI00023788   IPI00795404   
Protein Interaction databases
DIP (DOE-UCLA)P98073
IntAct (EBI)P98073
FunCoupENSG00000154646
BioGRIDTMPRSS15
STRING (EMBL)TMPRSS15
ZODIACTMPRSS15
Ontologies - Pathways
QuickGOP98073
Ontology : AmiGOserine-type endopeptidase activity  scavenger receptor activity  protein binding  brush border  proteolysis  receptor-mediated endocytosis  integral component of membrane  
Ontology : EGO-EBIserine-type endopeptidase activity  scavenger receptor activity  protein binding  brush border  proteolysis  receptor-mediated endocytosis  integral component of membrane  
NDEx NetworkTMPRSS15
Atlas of Cancer Signalling NetworkTMPRSS15
Wikipedia pathwaysTMPRSS15
Orthology - Evolution
OrthoDB5651
GeneTree (enSembl)ENSG00000154646
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS15
HOVERGENP98073
HOGENOMP98073
Homologs : HomoloGeneTMPRSS15
Homology/Alignments : Family Browser (UCSC)TMPRSS15
Gene fusions - Rearrangements
Fusion : MitelmanANK3/TMPRSS15 [10q21.2/21q21.1]  [t(10;21)(q21;q21)]  
Fusion : MitelmanPOU1F1/TMPRSS15 [3p11.2/21q21.1]  [t(3;21)(p11;q21)]  
Fusion: TCGAANK3 10q21.2 TMPRSS15 21q21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS15
dbVarTMPRSS15
ClinVarTMPRSS15
1000_GenomesTMPRSS15 
Exome Variant ServerTMPRSS15
ExAC (Exome Aggregation Consortium)TMPRSS15 (select the gene name)
Genetic variants : HAPMAP5651
Genomic Variants (DGV)TMPRSS15 [DGVbeta]
DECIPHERTMPRSS15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS15 
Mutations
ICGC Data PortalTMPRSS15 
TCGA Data PortalTMPRSS15 
Broad Tumor PortalTMPRSS15
OASIS PortalTMPRSS15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMPRSS15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMPRSS15
DgiDB (Drug Gene Interaction Database)TMPRSS15
DoCM (Curated mutations)TMPRSS15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS15 (select a term)
intoGenTMPRSS15
Cancer3DTMPRSS15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM226200    606635   
Orphanet17781   
MedgenTMPRSS15
Genetic Testing Registry TMPRSS15
NextProtP98073 [Medical]
TSGene5651
GENETestsTMPRSS15
Target ValidationTMPRSS15
Huge Navigator TMPRSS15 [HugePedia]
snp3D : Map Gene to Disease5651
BioCentury BCIQTMPRSS15
ClinGenTMPRSS15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5651
Chemical/Pharm GKB GenePA33839
Clinical trialTMPRSS15
Miscellaneous
canSAR (ICR)TMPRSS15 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMPRSS15
EVEXTMPRSS15
GoPubMedTMPRSS15
iHOPTMPRSS15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:59:52 CEST 2017

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