TMPRSS2 (transmembrane protease, serine 2)

Identity

Other names	PRSS10
Hugo	TMPRSS2
Location	21q22.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
Hugo	TMPRSS2
GDB	TMPRSS2
Entrez_Gene	TMPRSS2  7113  transmembrane protease, serine 2
	Cards
GeneCards	TMPRSS2
Ensembl	TMPRSS2 [Search_View]   ENSG00000184012 [Gene_View]
Genatlas	TMPRSS2
GeneLynx	TMPRSS2
eGenome	TMPRSS2
euGene	7113
	Genomic and cartography
GoldenPath	TMPRSS2  -  21q22.3   chr21:41758351-41801948 -  21q22.3   [Description]    (hg18-March_2006)
Ensembl	TMPRSS2 - 21q22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TMPRSS2
	Gene and transcription
Genbank	AF123453 [ ENTREZ ]
Genbank	AF270487 [ ENTREZ ]
Genbank	AF329454 [ ENTREZ ]
Genbank	AK222784 [ ENTREZ ]
Genbank	BC015819 [ ENTREZ ]
RefSeq	NM_005656 [ SRS ]    NM_005656 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	TMPRSS2 AceView - NCBI
Unigene	Hs.439309 [ SRS ]    Hs.439309 [ NCBI ]     HS439309 [ spliceNest ]
Fast-db	3123 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15393 [ SRS]    O15393 [ EXPASY ]     O15393 [ INTERPRO ]
Prosite	PS01209 LDLRA_1 [ SRS ]    PS01209 LDLRA_1 [ Expasy ]
Prosite	PS50068 LDLRA_2 [ SRS ]    PS50068 LDLRA_2 [ Expasy ]
Prosite	PS00420 SRCR_1 [ SRS ]    PS00420 SRCR_1 [ Expasy ]
Prosite	PS50287 SRCR_2 [ SRS ]    PS50287 SRCR_2 [ Expasy ]
Prosite	PS50240 TRYPSIN_DOM [ SRS ]    PS50240 TRYPSIN_DOM [ Expasy ]
Prosite	PS00134 TRYPSIN_HIS [ SRS ]    PS00134 TRYPSIN_HIS [ Expasy ]
Prosite	PS00135 TRYPSIN_SER [ SRS ]    PS00135 TRYPSIN_SER [ Expasy ]
Interpro	IPR002172 LDL_rcpt_classA_cys-rich [ SRS ]    IPR002172 LDL_rcpt_classA_cys-rich [ EBI ]
Interpro	IPR001254 Peptidase_S1_S6 [ SRS ]    IPR001254 Peptidase_S1_S6 [ EBI ]
Interpro	IPR001314 Peptidase_S1A [ SRS ]    IPR001314 Peptidase_S1A [ EBI ]
Interpro	IPR001190 Srcr_rcpt [ SRS ]    IPR001190 Srcr_rcpt [ EBI ]
CluSTr	O15393
Pfam	PF00530 SRCR [ SRS ]    PF00530 SRCR [ Sanger ]    pfam00530 [ NCBI-CDD ]
Pfam	PF00089 Trypsin [ SRS ]    PF00089 Trypsin [ Sanger ]    pfam00089 [ NCBI-CDD ]
Smart	SM00192 LDLa [EMBL]
Smart	SM00202 SR [EMBL]
Smart	SM00020 Tryp_SPc [EMBL]
Blocks	O15393
HPRD	03637
	Protein Interaction databases
DIP	O15393
IntAct	O15393
	Polymorphism : SNP, mutations, diseases
OMIM	602060    [ map ]
GENECLINICS	602060
SNP	TMPRSS2 [dbSNP-NCBI]
SNP	NM_005656 [SNP-NCI]
SNP	TMPRSS2 [GeneSNPs - Utah]  TMPRSS2] [HGBASE - SRS]
HAPMAP	TMPRSS2 [HAPMAP]
COSMIC	TMPRSS2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TMPRSS2
	General knowledge
Family Browser	TMPRSS2 [UCSC Family Browser]
SOURCE	NM_005656
SMD	Hs.439309
SAGE	Hs.439309
Enzyme	3.4.21.- [ Enzyme-SRS ]   3.4.21.- [ Brenda-SRS ]   3.4.21.- [ KEGG ]   3.4.21.- [ WIT ]
GO	serine-type endopeptidase activity [Amigo]  serine-type endopeptidase activity
GO	scavenger receptor activity [Amigo]  scavenger receptor activity
GO	extracellular region [Amigo]  extracellular region
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	proteolysis [Amigo]  proteolysis
PubGene	TMPRSS2
TreeFam	TMPRSS2
CTD	7113 [Comparative Genomics Database]
	Other databases
	Probes
Probe	TMPRSS2 Related clones (RZPD - Berlin)
	PubMed
PubMed	22 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:32:23 2008