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TMPRSS5 (transmembrane protease, serine 5)

Identity

Alias_symbol (synonym)MGC141886
MGC148044
Other aliasSPINESIN
HGNC (Hugo) TMPRSS5
LocusID (NCBI) 80975
Atlas_Id 75016
Location 11q23.2  [Link to chromosome band 11q23]
Location_base_pair Starts at 113687546 and ends at 113706373 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMPRSS5   14908
Cards
Entrez_Gene (NCBI)TMPRSS5  80975  transmembrane protease, serine 5
AliasesSPINESIN
GeneCards (Weizmann)TMPRSS5
Ensembl hg19 (Hinxton)ENSG00000166682 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166682 [Gene_View]  chr11:113687546-113706373 [Contig_View]  TMPRSS5 [Vega]
ICGC DataPortalENSG00000166682
TCGA cBioPortalTMPRSS5
AceView (NCBI)TMPRSS5
Genatlas (Paris)TMPRSS5
WikiGenes80975
SOURCE (Princeton)TMPRSS5
Genetics Home Reference (NIH)TMPRSS5
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS5  -     chr11:113687546-113706373 -  11q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS5  -     11q23.2   [Description]    (hg19-Feb_2009)
EnsemblTMPRSS5 - 11q23.2 [CytoView hg19]  TMPRSS5 - 11q23.2 [CytoView hg38]
Mapping of homologs : NCBITMPRSS5 [Mapview hg19]  TMPRSS5 [Mapview hg38]
OMIM606751   
Gene and transcription
Genbank (Entrez)AB028140 AI056603 AK294313 AK295366 AL538140
RefSeq transcript (Entrez)NM_001288749 NM_001288750 NM_001288751 NM_001288752 NM_030770
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMPRSS5
Cluster EST : UnigeneHs.46720 [ NCBI ]
CGAP (NCI)Hs.46720
Alternative Splicing GalleryENSG00000166682
Gene ExpressionTMPRSS5 [ NCBI-GEO ]   TMPRSS5 [ EBI - ARRAY_EXPRESS ]   TMPRSS5 [ SEEK ]   TMPRSS5 [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80975
GTEX Portal (Tissue expression)TMPRSS5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S3
Splice isoforms : SwissVarQ9H3S3
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ9H3S3
Domaine pattern : Prosite (Expaxy)SRCR_1 (PS00420)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    SRCR    SRCR-like_dom    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)SRCR_2 (PF15494)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam15494    pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS5
DMDM Disease mutations80975
Blocks (Seattle)TMPRSS5
SuperfamilyQ9H3S3
Human Protein AtlasENSG00000166682
Peptide AtlasQ9H3S3
HPRD05995
IPIIPI00216432   IPI01012163   IPI01010448   IPI01010169   IPI01010490   IPI00922122   IPI01015020   IPI01013378   IPI01015792   IPI01014184   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S3
IntAct (EBI)Q9H3S3
FunCoupENSG00000166682
BioGRIDTMPRSS5
STRING (EMBL)TMPRSS5
ZODIACTMPRSS5
Ontologies - Pathways
QuickGOQ9H3S3
Ontology : AmiGOserine-type endopeptidase activity  scavenger receptor activity  plasma membrane  proteolysis  receptor-mediated endocytosis  peptidase activity  integral component of membrane  neuronal cell body  
Ontology : EGO-EBIserine-type endopeptidase activity  scavenger receptor activity  plasma membrane  proteolysis  receptor-mediated endocytosis  peptidase activity  integral component of membrane  neuronal cell body  
NDEx NetworkTMPRSS5
Atlas of Cancer Signalling NetworkTMPRSS5
Wikipedia pathwaysTMPRSS5
Orthology - Evolution
OrthoDB80975
GeneTree (enSembl)ENSG00000166682
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS5
HOVERGENQ9H3S3
HOGENOMQ9H3S3
Homologs : HomoloGeneTMPRSS5
Homology/Alignments : Family Browser (UCSC)TMPRSS5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS5
dbVarTMPRSS5
ClinVarTMPRSS5
1000_GenomesTMPRSS5 
Exome Variant ServerTMPRSS5
ExAC (Exome Aggregation Consortium)TMPRSS5 (select the gene name)
Genetic variants : HAPMAP80975
Genomic Variants (DGV)TMPRSS5 [DGVbeta]
DECIPHERTMPRSS5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS5 
Mutations
ICGC Data PortalTMPRSS5 
TCGA Data PortalTMPRSS5 
Broad Tumor PortalTMPRSS5
OASIS PortalTMPRSS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMPRSS5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMPRSS5
DgiDB (Drug Gene Interaction Database)TMPRSS5
DoCM (Curated mutations)TMPRSS5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS5 (select a term)
intoGenTMPRSS5
Cancer3DTMPRSS5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606751   
Orphanet
MedgenTMPRSS5
Genetic Testing Registry TMPRSS5
NextProtQ9H3S3 [Medical]
TSGene80975
GENETestsTMPRSS5
Target ValidationTMPRSS5
Huge Navigator TMPRSS5 [HugePedia]
snp3D : Map Gene to Disease80975
BioCentury BCIQTMPRSS5
ClinGenTMPRSS5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80975
Chemical/Pharm GKB GenePA37920
Clinical trialTMPRSS5
Miscellaneous
canSAR (ICR)TMPRSS5 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMPRSS5
EVEXTMPRSS5
GoPubMedTMPRSS5
iHOPTMPRSS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:42:11 CEST 2017

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