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TMPRSS9 (transmembrane serine protease 9)

Identity

Alias (NCBI)-
HGNC (Hugo) TMPRSS9
HGNC Alias namepolyserase 1
LocusID (NCBI) 360200
Atlas_Id 75018
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2389771 and ends at 2426258 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED1 (17q12) / TMPRSS9 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(9;19)(p13;p13) TMPRSS9/PAX5
t(9;19)(p13;p13) TMPRSS9/PAX5


External links

 

Nomenclature
HGNC (Hugo)TMPRSS9   30079
Cards
Entrez_Gene (NCBI)TMPRSS9    transmembrane serine protease 9
Aliases
GeneCards (Weizmann)TMPRSS9
Ensembl hg19 (Hinxton)ENSG00000178297 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178297 [Gene_View]  ENSG00000178297 [Sequence]  chr19:2389771-2426258 [Contig_View]  TMPRSS9 [Vega]
ICGC DataPortalENSG00000178297
TCGA cBioPortalTMPRSS9
AceView (NCBI)TMPRSS9
Genatlas (Paris)TMPRSS9
SOURCE (Princeton)TMPRSS9
Genetics Home Reference (NIH)TMPRSS9
Genomic and cartography
GoldenPath hg38 (UCSC)TMPRSS9  -     chr19:2389771-2426258 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMPRSS9  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTMPRSS9 - 19p13.3 [CytoView hg19]  TMPRSS9 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000178297
Genome Data Viewer NCBITMPRSS9 [Mapview hg19]  
OMIM610477   
Gene and transcription
Genbank (Entrez)AB109390 AJ488946 AJ488947 AK131261
RefSeq transcript (Entrez)NM_001385642 NM_182973
Consensus coding sequences : CCDS (NCBI)TMPRSS9
Gene ExpressionTMPRSS9 [ NCBI-GEO ]   TMPRSS9 [ EBI - ARRAY_EXPRESS ]   TMPRSS9 [ SEEK ]   TMPRSS9 [ MEM ]
Gene Expression Viewer (FireBrowse)TMPRSS9 [ Firebrowse - Broad ]
GenevisibleExpression of TMPRSS9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)360200
GTEX Portal (Tissue expression)TMPRSS9
Human Protein AtlasENSG00000178297-TMPRSS9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z410   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z410  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z410
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ7Z410
Domaine pattern : Prosite (Expaxy)LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)LDL_receptor-like_sf    LDrepeatLR_classA_rpt    Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Tmprss9    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Ldl_recept_a (PF00057)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00057    pfam00089   
Domain families : Smart (EMBL)LDLa (SM00192)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TMPRSS9
SuperfamilyQ7Z410
AlphaFold pdb e-kbQ7Z410   
Human Protein Atlas [tissue]ENSG00000178297-TMPRSS9 [tissue]
HPRD07124
Protein Interaction databases
DIP (DOE-UCLA)Q7Z410
IntAct (EBI)Q7Z410
BioGRIDTMPRSS9
STRING (EMBL)TMPRSS9
ZODIACTMPRSS9
Ontologies - Pathways
QuickGOQ7Z410
Ontology : AmiGOserine-type endopeptidase activity  integral component of plasma membrane  proteolysis  
Ontology : EGO-EBIserine-type endopeptidase activity  integral component of plasma membrane  proteolysis  
NDEx NetworkTMPRSS9
Atlas of Cancer Signalling NetworkTMPRSS9
Wikipedia pathwaysTMPRSS9
Orthology - Evolution
OrthoDB360200
GeneTree (enSembl)ENSG00000178297
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS9
Homologs : HomoloGeneTMPRSS9
Homology/Alignments : Family Browser (UCSC)TMPRSS9
Gene fusions - Rearrangements
Fusion : QuiverTMPRSS9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMPRSS9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMPRSS9
dbVarTMPRSS9
ClinVarTMPRSS9
MonarchTMPRSS9
1000_GenomesTMPRSS9 
Exome Variant ServerTMPRSS9
GNOMAD BrowserENSG00000178297
Varsome BrowserTMPRSS9
ACMGTMPRSS9 variants
VarityQ7Z410
Genomic Variants (DGV)TMPRSS9 [DGVbeta]
DECIPHERTMPRSS9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMPRSS9 
Mutations
ICGC Data PortalTMPRSS9 
TCGA Data PortalTMPRSS9 
Broad Tumor PortalTMPRSS9
OASIS PortalTMPRSS9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMPRSS9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMPRSS9
Mutations and Diseases : HGMDTMPRSS9
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMPRSS9
DgiDB (Drug Gene Interaction Database)TMPRSS9
DoCM (Curated mutations)TMPRSS9
CIViC (Clinical Interpretations of Variants in Cancer)TMPRSS9
Cancer3DTMPRSS9
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610477   
Orphanet
DisGeNETTMPRSS9
MedgenTMPRSS9
Genetic Testing Registry TMPRSS9
NextProtQ7Z410 [Medical]
GENETestsTMPRSS9
Target ValidationTMPRSS9
Huge Navigator TMPRSS9 [HugePedia]
ClinGenTMPRSS9
Clinical trials, drugs, therapy
MyCancerGenomeTMPRSS9
Protein Interactions : CTDTMPRSS9
Pharm GKB GenePA134967594
PharosQ7Z410
Clinical trialTMPRSS9
Miscellaneous
canSAR (ICR)TMPRSS9
HarmonizomeTMPRSS9
DataMed IndexTMPRSS9
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMPRSS9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:26 CEST 2021

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