Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TMSB4X (thymosin beta 4 X-linked)

Identity

Alias (NCBI)FX
PTMB4
TB4X
TMSB4
HGNC (Hugo) TMSB4X
HGNC Alias symbTB4X
HGNC Previous nameTMSB4
HGNC Previous namethymosin, beta 4, X chromosome
LocusID (NCBI) 7114
Atlas_Id 42596
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 12975110 and ends at 12977220 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMSB4X (Xp22.2) / CROCC (1p36.13)TMSB4X (Xp22.2) / SC5D (11q23.3)TMSB4X (Xp22.2) / TSPAN7 (Xp11.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMSB4X   11881
Cards
Entrez_Gene (NCBI)TMSB4X    thymosin beta 4 X-linked
AliasesFX; PTMB4; TB4X; TMSB4
GeneCards (Weizmann)TMSB4X
Ensembl hg19 (Hinxton)ENSG00000205542 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205542 [Gene_View]  ENSG00000205542 [Sequence]  chrX:12975110-12977220 [Contig_View]  TMSB4X [Vega]
ICGC DataPortalENSG00000205542
TCGA cBioPortalTMSB4X
AceView (NCBI)TMSB4X
Genatlas (Paris)TMSB4X
SOURCE (Princeton)TMSB4X
Genetics Home Reference (NIH)TMSB4X
Genomic and cartography
GoldenPath hg38 (UCSC)TMSB4X  -     chrX:12975110-12977220 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMSB4X  -     Xp22.2   [Description]    (hg19-Feb_2009)
GoldenPathTMSB4X - Xp22.2 [CytoView hg19]  TMSB4X - Xp22.2 [CytoView hg38]
ImmunoBaseENSG00000205542
Genome Data Viewer NCBITMSB4X [Mapview hg19]  
OMIM300159   
Gene and transcription
Genbank (Entrez)AK055976 AK057827 AK311747 AV715954 BC001631
RefSeq transcript (Entrez)NM_021109
Consensus coding sequences : CCDS (NCBI)TMSB4X
Gene ExpressionTMSB4X [ NCBI-GEO ]   TMSB4X [ EBI - ARRAY_EXPRESS ]   TMSB4X [ SEEK ]   TMSB4X [ MEM ]
Gene Expression Viewer (FireBrowse)TMSB4X [ Firebrowse - Broad ]
GenevisibleExpression of TMSB4X in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7114
GTEX Portal (Tissue expression)TMSB4X
Human Protein AtlasENSG00000205542-TMSB4X [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62328
PhosPhoSitePlusP62328
Domaine pattern : Prosite (Expaxy)THYMOSIN_B4 (PS00500)   
Domains : Interpro (EBI)Beta-thymosin    Beta-thymosin_sf   
Domain families : Pfam (Sanger)Thymosin (PF01290)   
Domain families : Pfam (NCBI)pfam01290   
Domain families : Smart (EMBL)THY (SM00152)  
Conserved Domain (NCBI)TMSB4X
PDB (RSDB)1UY5    3TU5    4PL7    4PL8   
PDB Europe1UY5    3TU5    4PL7    4PL8   
PDB (PDBSum)1UY5    3TU5    4PL7    4PL8   
PDB (IMB)1UY5    3TU5    4PL7    4PL8   
Structural Biology KnowledgeBase1UY5    3TU5    4PL7    4PL8   
SCOP (Structural Classification of Proteins)1UY5    3TU5    4PL7    4PL8   
CATH (Classification of proteins structures)1UY5    3TU5    4PL7    4PL8   
SuperfamilyP62328
AlphaFold pdb e-kbP62328   
Human Protein Atlas [tissue]ENSG00000205542-TMSB4X [tissue]
HPRD02153
Protein Interaction databases
DIP (DOE-UCLA)P62328
IntAct (EBI)P62328
BioGRIDTMSB4X
STRING (EMBL)TMSB4X
ZODIACTMSB4X
Ontologies - Pathways
QuickGOP62328
Ontology : AmiGOplatelet degranulation  RNA binding  actin monomer binding  actin monomer binding  protein binding  extracellular region  extracellular region  nucleus  cytoplasm  cytoplasm  cytosol  cytoskeleton  actin filament organization  cytoplasmic sequestering of NF-kappaB  enzyme binding  regulation of cell migration  platelet alpha granule lumen  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-8 production  tumor necrosis factor-mediated signaling pathway  sequestering of actin monomers  sequestering of actin monomers  positive regulation of blood vessel endothelial cell migration  positive regulation of blood vessel endothelial cell migration  regulation of inflammatory response  regulation of NIK/NF-kappaB signaling  negative regulation of NIK/NF-kappaB signaling  negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  positive regulation of proton-transporting ATP synthase activity, rotational mechanism  positive regulation of endothelial cell chemotaxis  positive regulation of ATP biosynthetic process  
Ontology : EGO-EBIplatelet degranulation  RNA binding  actin monomer binding  actin monomer binding  protein binding  extracellular region  extracellular region  nucleus  cytoplasm  cytoplasm  cytosol  cytoskeleton  actin filament organization  cytoplasmic sequestering of NF-kappaB  enzyme binding  regulation of cell migration  platelet alpha granule lumen  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-8 production  tumor necrosis factor-mediated signaling pathway  sequestering of actin monomers  sequestering of actin monomers  positive regulation of blood vessel endothelial cell migration  positive regulation of blood vessel endothelial cell migration  regulation of inflammatory response  regulation of NIK/NF-kappaB signaling  negative regulation of NIK/NF-kappaB signaling  negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  positive regulation of proton-transporting ATP synthase activity, rotational mechanism  positive regulation of endothelial cell chemotaxis  positive regulation of ATP biosynthetic process  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkTMSB4X
Atlas of Cancer Signalling NetworkTMSB4X
Wikipedia pathwaysTMSB4X
Orthology - Evolution
OrthoDB7114
GeneTree (enSembl)ENSG00000205542
Phylogenetic Trees/Animal Genes : TreeFamTMSB4X
Homologs : HomoloGeneTMSB4X
Homology/Alignments : Family Browser (UCSC)TMSB4X
Gene fusions - Rearrangements
Fusion : QuiverTMSB4X
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMSB4X [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMSB4X
dbVarTMSB4X
ClinVarTMSB4X
MonarchTMSB4X
1000_GenomesTMSB4X 
Exome Variant ServerTMSB4X
GNOMAD BrowserENSG00000205542
Varsome BrowserTMSB4X
ACMGTMSB4X variants
VarityP62328
Genomic Variants (DGV)TMSB4X [DGVbeta]
DECIPHERTMSB4X [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMSB4X 
Mutations
ICGC Data PortalTMSB4X 
TCGA Data PortalTMSB4X 
Broad Tumor PortalTMSB4X
OASIS PortalTMSB4X [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMSB4X  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMSB4X
Mutations and Diseases : HGMDTMSB4X
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMSB4X
DgiDB (Drug Gene Interaction Database)TMSB4X
DoCM (Curated mutations)TMSB4X
CIViC (Clinical Interpretations of Variants in Cancer)TMSB4X
Cancer3DTMSB4X
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300159   
Orphanet
DisGeNETTMSB4X
MedgenTMSB4X
Genetic Testing Registry TMSB4X
NextProtP62328 [Medical]
GENETestsTMSB4X
Target ValidationTMSB4X
Huge Navigator TMSB4X [HugePedia]
ClinGenTMSB4X
Clinical trials, drugs, therapy
MyCancerGenomeTMSB4X
Protein Interactions : CTDTMSB4X
Pharm GKB GenePA36581
PharosP62328
Clinical trialTMSB4X
Miscellaneous
canSAR (ICR)TMSB4X
HarmonizomeTMSB4X
DataMed IndexTMSB4X
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMSB4X
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:38 CEST 2021

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