TMX1 (thioredoxin related transmembrane protein 1)

2021-06-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
PDIA11,TMX,TXNDC,TXNDC1

Other Information

Locus ID:

NCBI: 81542
MIM: 610527
HGNC: 15487
Ensembl: ENSG00000139921

Variants:

dbSNP: 81542
ClinVar: 81542
TCGA: ENSG00000139921
COSMIC: TMX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139921ENST00000457354Q9H3N1
ENSG00000139921ENST00000556683G3V448

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220453382012Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.72
275024842016TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.23
197410922009Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses.12
262466042015Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides.9
222287642012Reductive activation of type 2 ribosome-inactivating proteins is promoted by transmembrane thioredoxin-related protein.8
229248222013The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury.4
313049842019Redox signals at the ER-mitochondria interface control melanoma progression.4
299329152018The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides.1

Citation

Dessen P

TMX1 (thioredoxin related transmembrane protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58205/tmx1