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TMX2 (thioredoxin related transmembrane protein 2)

Identity

Alias (NCBI)CGI-31
NEDMCMS
PDIA12
PIG26
TXNDC14
HGNC (Hugo) TMX2
HGNC Alias symbPDIA12
HGNC Alias nameprotein disulfide isomerase family A, member 12
HGNC Previous nameTXNDC14
HGNC Previous namethioredoxin domain containing 14
 thioredoxin-related transmembrane protein 2
LocusID (NCBI) 51075
Atlas_Id 75028
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57712593 and ends at 57740973 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTNND1 (11q12.1) / TMX2 (11q12.1)TMX2 (11q12.1) / C11orf80 (11q13.2)TMX2 (11q12.1) / CTNND1 (11q12.1)
TMX2 (11q12.1) / PICALM (11q14.2)TMX2 (11q12.1) / SMTNL1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMX2   30739
Cards
Entrez_Gene (NCBI)TMX2    thioredoxin related transmembrane protein 2
AliasesCGI-31; NEDMCMS; PDIA12; PIG26; 
TXNDC14
GeneCards (Weizmann)TMX2
Ensembl hg19 (Hinxton)ENSG00000213593 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213593 [Gene_View]  ENSG00000213593 [Sequence]  chr11:57712593-57740973 [Contig_View]  TMX2 [Vega]
ICGC DataPortalENSG00000213593
TCGA cBioPortalTMX2
AceView (NCBI)TMX2
Genatlas (Paris)TMX2
SOURCE (Princeton)TMX2
Genetics Home Reference (NIH)TMX2
Genomic and cartography
GoldenPath hg38 (UCSC)TMX2  -     chr11:57712593-57740973 +  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMX2  -     11q12.1   [Description]    (hg19-Feb_2009)
GoldenPathTMX2 - 11q12.1 [CytoView hg19]  TMX2 - 11q12.1 [CytoView hg38]
ImmunoBaseENSG00000213593
Genome Data Viewer NCBITMX2 [Mapview hg19]  
OMIM616715   618730   
Gene and transcription
Genbank (Entrez)AF059753 AF132965 AK075359 AK223058 AK297688
RefSeq transcript (Entrez)NM_001144012 NM_001347890 NM_001347891 NM_001347892 NM_001347893 NM_001347894 NM_001347895 NM_001347896 NM_001347898 NM_015959
Consensus coding sequences : CCDS (NCBI)TMX2
Gene ExpressionTMX2 [ NCBI-GEO ]   TMX2 [ EBI - ARRAY_EXPRESS ]   TMX2 [ SEEK ]   TMX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMX2 [ Firebrowse - Broad ]
GenevisibleExpression of TMX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51075
GTEX Portal (Tissue expression)TMX2
Human Protein AtlasENSG00000213593-TMX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y320   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y320  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y320
PhosPhoSitePlusQ9Y320
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_sf    Thioredoxin_domain    TMX2    TMX2_thioredoxin_dom   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TMX2
PDB (RSDB)2DJ0   
PDB Europe2DJ0   
PDB (PDBSum)2DJ0   
PDB (IMB)2DJ0   
Structural Biology KnowledgeBase2DJ0   
SCOP (Structural Classification of Proteins)2DJ0   
CATH (Classification of proteins structures)2DJ0   
SuperfamilyQ9Y320
AlphaFold pdb e-kbQ9Y320   
Human Protein Atlas [tissue]ENSG00000213593-TMX2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9Y320
IntAct (EBI)Q9Y320
BioGRIDTMX2
STRING (EMBL)TMX2
ZODIACTMX2
Ontologies - Pathways
QuickGOQ9Y320
Ontology : AmiGOprotein binding  mitochondrion  endoplasmic reticulum membrane  brain development  brain development  disulfide oxidoreductase activity  disulfide oxidoreductase activity  integral component of membrane  mitochondrial membrane  identical protein binding  membrane-bounded organelle  mitochondria-associated endoplasmic reticulum membrane  
Ontology : EGO-EBIprotein binding  mitochondrion  endoplasmic reticulum membrane  brain development  brain development  disulfide oxidoreductase activity  disulfide oxidoreductase activity  integral component of membrane  mitochondrial membrane  identical protein binding  membrane-bounded organelle  mitochondria-associated endoplasmic reticulum membrane  
NDEx NetworkTMX2
Atlas of Cancer Signalling NetworkTMX2
Wikipedia pathwaysTMX2
Orthology - Evolution
OrthoDB51075
GeneTree (enSembl)ENSG00000213593
Phylogenetic Trees/Animal Genes : TreeFamTMX2
Homologs : HomoloGeneTMX2
Homology/Alignments : Family Browser (UCSC)TMX2
Gene fusions - Rearrangements
Fusion : QuiverTMX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMX2
dbVarTMX2
ClinVarTMX2
MonarchTMX2
1000_GenomesTMX2 
Exome Variant ServerTMX2
GNOMAD BrowserENSG00000213593
Varsome BrowserTMX2
ACMGTMX2 variants
VarityQ9Y320
Genomic Variants (DGV)TMX2 [DGVbeta]
DECIPHERTMX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMX2 
Mutations
ICGC Data PortalTMX2 
TCGA Data PortalTMX2 
Broad Tumor PortalTMX2
OASIS PortalTMX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMX2
Mutations and Diseases : HGMDTMX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMX2
DgiDB (Drug Gene Interaction Database)TMX2
DoCM (Curated mutations)TMX2
CIViC (Clinical Interpretations of Variants in Cancer)TMX2
Cancer3DTMX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616715    618730   
Orphanet
DisGeNETTMX2
MedgenTMX2
Genetic Testing Registry TMX2
NextProtQ9Y320 [Medical]
GENETestsTMX2
Target ValidationTMX2
Huge Navigator TMX2 [HugePedia]
ClinGenTMX2
Clinical trials, drugs, therapy
MyCancerGenomeTMX2
Protein Interactions : CTDTMX2
Pharm GKB GenePA164726611
PharosQ9Y320
Clinical trialTMX2
Miscellaneous
canSAR (ICR)TMX2
HarmonizomeTMX2
DataMed IndexTMX2
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:28 CEST 2021

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