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TMX2 (thioredoxin-related transmembrane protein 2)

Identity

Alias_namesTXNDC14
thioredoxin domain containing 14
thioredoxin-related transmembrane protein 2
Alias_symbol (synonym)PDIA12
Other aliasCGI-31
PIG26
HGNC (Hugo) TMX2
LocusID (NCBI) 51075
Atlas_Id 75028
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57479995 and ends at 57508445 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTNND1 (11q12.1) / TMX2 (11q12.1)TMX2 (11q12.1) / C11orf80 (11q13.2)TMX2 (11q12.1) / CTNND1 (11q12.1)
TMX2 (11q12.1) / PICALM (11q14.2)TMX2 (11q12.1) / SMTNL1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TMX2   30739
Cards
Entrez_Gene (NCBI)TMX2  51075  thioredoxin-related transmembrane protein 2
AliasesCGI-31; PDIA12; PIG26; TXNDC14
GeneCards (Weizmann)TMX2
Ensembl hg19 (Hinxton)ENSG00000213593 [Gene_View]  chr11:57479995-57508445 [Contig_View]  TMX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000213593 [Gene_View]  chr11:57479995-57508445 [Contig_View]  TMX2 [Vega]
ICGC DataPortalENSG00000213593
TCGA cBioPortalTMX2
AceView (NCBI)TMX2
Genatlas (Paris)TMX2
WikiGenes51075
SOURCE (Princeton)TMX2
Genetics Home Reference (NIH)TMX2
Genomic and cartography
GoldenPath hg19 (UCSC)TMX2  -     chr11:57479995-57508445 +  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMX2  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblTMX2 - 11q12.1 [CytoView hg19]  TMX2 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBITMX2 [Mapview hg19]  TMX2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF059753 AF132965 AK075359 AK223058 AK297688
RefSeq transcript (Entrez)NM_001144012 NM_015959
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)TMX2
Cluster EST : UnigeneHs.654965 [ NCBI ]
CGAP (NCI)Hs.654965
Alternative Splicing GalleryENSG00000213593
Gene ExpressionTMX2 [ NCBI-GEO ]   TMX2 [ EBI - ARRAY_EXPRESS ]   TMX2 [ SEEK ]   TMX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TMX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51075
GTEX Portal (Tissue expression)TMX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y320   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y320  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y320
Splice isoforms : SwissVarQ9Y320
PhosPhoSitePlusQ9Y320
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TMX2
DMDM Disease mutations51075
Blocks (Seattle)TMX2
PDB (SRS)2DJ0   
PDB (PDBSum)2DJ0   
PDB (IMB)2DJ0   
PDB (RSDB)2DJ0   
Structural Biology KnowledgeBase2DJ0   
SCOP (Structural Classification of Proteins)2DJ0   
CATH (Classification of proteins structures)2DJ0   
SuperfamilyQ9Y320
Human Protein AtlasENSG00000213593
Peptide AtlasQ9Y320
IPIIPI00556619   IPI00329596   IPI00983115   IPI00975551   IPI00984709   IPI00977357   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y320
IntAct (EBI)Q9Y320
FunCoupENSG00000213593
BioGRIDTMX2
STRING (EMBL)TMX2
ZODIACTMX2
Ontologies - Pathways
QuickGOQ9Y320
Ontology : AmiGOmolecular_function  cellular_component  cell  biological_process  integral component of membrane  cell redox homeostasis  
Ontology : EGO-EBImolecular_function  cellular_component  cell  biological_process  integral component of membrane  cell redox homeostasis  
NDEx NetworkTMX2
Atlas of Cancer Signalling NetworkTMX2
Wikipedia pathwaysTMX2
Orthology - Evolution
OrthoDB51075
GeneTree (enSembl)ENSG00000213593
Phylogenetic Trees/Animal Genes : TreeFamTMX2
HOVERGENQ9Y320
HOGENOMQ9Y320
Homologs : HomoloGeneTMX2
Homology/Alignments : Family Browser (UCSC)TMX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMX2
dbVarTMX2
ClinVarTMX2
1000_GenomesTMX2 
Exome Variant ServerTMX2
ExAC (Exome Aggregation Consortium)TMX2 (select the gene name)
Genetic variants : HAPMAP51075
Genomic Variants (DGV)TMX2 [DGVbeta]
DECIPHER (Syndromes)11:57479995-57508445  ENSG00000213593
CONAN: Copy Number AnalysisTMX2 
Mutations
ICGC Data PortalTMX2 
TCGA Data PortalTMX2 
Broad Tumor PortalTMX2
OASIS PortalTMX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMX2
DgiDB (Drug Gene Interaction Database)TMX2
DoCM (Curated mutations)TMX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMX2 (select a term)
intoGenTMX2
Cancer3DTMX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTMX2
Genetic Testing Registry TMX2
NextProtQ9Y320 [Medical]
TSGene51075
GENETestsTMX2
Huge Navigator TMX2 [HugePedia]
snp3D : Map Gene to Disease51075
BioCentury BCIQTMX2
ClinGenTMX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51075
Chemical/Pharm GKB GenePA164726611
Clinical trialTMX2
Miscellaneous
canSAR (ICR)TMX2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMX2
EVEXTMX2
GoPubMedTMX2
iHOPTMX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:49:14 CET 2017

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