Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TMX3 (thioredoxin related transmembrane protein 3)

Identity

Alias (NCBI)PDIA13
TXNDC10
HGNC (Hugo) TMX3
HGNC Alias symbFLJ20793
KIAA1830
PDIA13
HGNC Alias nameprotein disulfide isomerase family A, member 13
HGNC Previous nameTXNDC10
HGNC Previous namethioredoxin domain containing 10
 thioredoxin-related transmembrane protein 3
LocusID (NCBI) 54495
Atlas_Id 58181
Location 18q22.1  [Link to chromosome band 18q22]
Location_base_pair Starts at 68673688 and ends at 68715108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMX3 (18q22.1) / METTL4 (18p11.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TMX3   24718
Cards
Entrez_Gene (NCBI)TMX3    thioredoxin related transmembrane protein 3
AliasesPDIA13; TXNDC10
GeneCards (Weizmann)TMX3
Ensembl hg19 (Hinxton)ENSG00000166479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166479 [Gene_View]  ENSG00000166479 [Sequence]  chr18:68673688-68715108 [Contig_View]  TMX3 [Vega]
ICGC DataPortalENSG00000166479
TCGA cBioPortalTMX3
AceView (NCBI)TMX3
Genatlas (Paris)TMX3
SOURCE (Princeton)TMX3
Genetics Home Reference (NIH)TMX3
Genomic and cartography
GoldenPath hg38 (UCSC)TMX3  -     chr18:68673688-68715108 -  18q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMX3  -     18q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTMX3 - 18q22.1 [CytoView hg19]  TMX3 - 18q22.1 [CytoView hg38]
ImmunoBaseENSG00000166479
Genome Data Viewer NCBITMX3 [Mapview hg19]  
OMIM616102   
Gene and transcription
Genbank (Entrez)AB058733 AK000800 AK025025 AK122715 AK295551
RefSeq transcript (Entrez)NM_001350512 NM_001350513 NM_001350514 NM_001350515 NM_001350516 NM_001350517 NM_019022
Consensus coding sequences : CCDS (NCBI)TMX3
Gene ExpressionTMX3 [ NCBI-GEO ]   TMX3 [ EBI - ARRAY_EXPRESS ]   TMX3 [ SEEK ]   TMX3 [ MEM ]
Gene Expression Viewer (FireBrowse)TMX3 [ Firebrowse - Broad ]
GenevisibleExpression of TMX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54495
GTEX Portal (Tissue expression)TMX3
Human Protein AtlasENSG00000166479-TMX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JJ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JJ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JJ7
Catalytic activity : Enzyme5.3.4.1 [ Enzyme-Expasy ]   5.3.4.15.3.4.1 [ IntEnz-EBI ]   5.3.4.1 [ BRENDA ]   5.3.4.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96JJ7
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TMX3
SuperfamilyQ96JJ7
AlphaFold pdb e-kbQ96JJ7   
Human Protein Atlas [tissue]ENSG00000166479-TMX3 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q96JJ7
IntAct (EBI)Q96JJ7
BioGRIDTMX3
STRING (EMBL)TMX3
ZODIACTMX3
Ontologies - Pathways
QuickGOQ96JJ7
Ontology : AmiGOplatelet degranulation  protein disulfide isomerase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  plasma membrane  cell surface  cell surface  protein-disulfide reductase activity  integral component of membrane  thiol oxidase activity  peptidyl-cysteine oxidation  peptidyl-cysteine oxidation  platelet alpha granule membrane  
Ontology : EGO-EBIplatelet degranulation  protein disulfide isomerase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  plasma membrane  cell surface  cell surface  protein-disulfide reductase activity  integral component of membrane  thiol oxidase activity  peptidyl-cysteine oxidation  peptidyl-cysteine oxidation  platelet alpha granule membrane  
NDEx NetworkTMX3
Atlas of Cancer Signalling NetworkTMX3
Wikipedia pathwaysTMX3
Orthology - Evolution
OrthoDB54495
GeneTree (enSembl)ENSG00000166479
Phylogenetic Trees/Animal Genes : TreeFamTMX3
Homologs : HomoloGeneTMX3
Homology/Alignments : Family Browser (UCSC)TMX3
Gene fusions - Rearrangements
Fusion : QuiverTMX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMX3
dbVarTMX3
ClinVarTMX3
MonarchTMX3
1000_GenomesTMX3 
Exome Variant ServerTMX3
GNOMAD BrowserENSG00000166479
Varsome BrowserTMX3
ACMGTMX3 variants
VarityQ96JJ7
Genomic Variants (DGV)TMX3 [DGVbeta]
DECIPHERTMX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMX3 
Mutations
ICGC Data PortalTMX3 
TCGA Data PortalTMX3 
Broad Tumor PortalTMX3
OASIS PortalTMX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMX3
Mutations and Diseases : HGMDTMX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTMX3
DgiDB (Drug Gene Interaction Database)TMX3
DoCM (Curated mutations)TMX3
CIViC (Clinical Interpretations of Variants in Cancer)TMX3
Cancer3DTMX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616102   
Orphanet
DisGeNETTMX3
MedgenTMX3
Genetic Testing Registry TMX3
NextProtQ96JJ7 [Medical]
GENETestsTMX3
Target ValidationTMX3
Huge Navigator TMX3 [HugePedia]
ClinGenTMX3
Clinical trials, drugs, therapy
MyCancerGenomeTMX3
Protein Interactions : CTDTMX3
PharosQ96JJ7
Clinical trialTMX3
Miscellaneous
canSAR (ICR)TMX3
HarmonizomeTMX3
DataMed IndexTMX3
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTMX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:39 CEST 2021

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