TNFAIP8L1 (TNF alpha induced protein 8 like 1)

2005-11-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
TIPE1
FUSION GENES

Other Information

Locus ID:

NCBI: 126282
MIM: 615869
HGNC: 28279
Ensembl: ENSG00000185361

Variants:

dbSNP: 126282
ClinVar: 126282
TCGA: ENSG00000185361
COSMIC: TNFAIP8L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185361ENST00000327473Q8WVP5
ENSG00000185361ENST00000536716Q8WVP5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255

References

Pubmed IDYearTitleCitations
250432992015TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.20
244444192014Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.17
216006552011The expression of TIPE1 in murine tissues and human cell lines.13
289942312018TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer.5
304456002019TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome.4
300625202019TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration.3
315594122019TIPE1 suppresses the invasion and migration of breast cancer cells and inhibits epithelial-to-mesenchymal transition primarily via the ERK signaling pathway.1

Citation

Dessen P

TNFAIP8L1 (TNF alpha induced protein 8 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43042/tnfaip8l1